1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. HDAC10 Inhibitors

HDAC10 Inhibitors

HDAC

HDAC1

HDAC2

HDAC3

HDAC4

HDAC5

HDAC6

HDAC7

HDAC8

HDAC9

HDAC10

HDAC11

HD1

HD2

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Sorry. There is currently no product that acts on isoform HDAC10 together.

Please try each isoform separately.

HDAC10 Specific Inhibitors
Product Name HDAC10 HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC11 HD1 HD2 HDAC10 Selectivity Purity
Tubacin
HDAC10, IC50: 3.71 μM
 
HDAC1, IC50: 1.40 μM
HDAC2, IC50: 6.27 μM
HDAC3, IC50: 1.27 μM
HDAC4, IC50: 17.30 μM
HDAC5, IC50: 3.35 μM
HDAC6, IC50: 4 nM
HDAC7, IC50: 9.70 μM
HDAC8, IC50: 1.27 μM
HDAC9, IC50: 4.31 μM
HDAC11, IC50: 3.79 μM
    Pan Inhibitor 98.87%
Fimepinostat
HDAC10, IC50: 2.8 nM
 
HDAC1, IC50: 1.7 nM
HDAC2, IC50: 5 nM
HDAC3, IC50: 1.8 nM
HDAC4, IC50: 409 nM
HDAC5, IC50: 674 nM
HDAC6, IC50: 27 nM
HDAC7, IC50: 426 nM
HDAC8, IC50: 191 nM
HDAC9, IC50: 554 nM
HDAC11, IC50: 5.4 nM
    Pan Inhibitor 99.95%
Abexinostat
HDAC10, Ki: 24 nM
 
HDAC1, Ki: 7 nM
HDAC2, Ki: 19 nM
HDAC3/SMRT, Ki: 8.2 nM
   
HDAC6, Ki: 17 nM
 
HDAC8, Ki: 280 nM
        Pan Inhibitor 98.61%
Nexturastat A
HDAC10, IC50: 7.57 μM
 
HDAC1, IC50: 3.02 μM
HDAC2, IC50: 6.92 μM
HDAC3, IC50: 6.68 μM
HDAC4, IC50: 9.39 μM
HDAC5, IC50: 11.7 μM
HDAC6, IC50: 5.02 nM
HDAC7, IC50: 4.46 μM
HDAC8, IC50: 0.954 μM
HDAC9, IC50: 6.72 μM
HDAC11, IC50: 5.14 μM
    Pan Inhibitor 97.92%
CAY10603
HDAC10, IC50: 90.7 nM
 
HDAC1, IC50: 271 nM
HDAC2, IC50: 252 nM
HDAC3, IC50: 0.42 nM
   
HDAC6, IC50: 0.002 nM
 
HDAC8, IC50: 6851 nM
        Pan Inhibitor 98.08%
Pracinostat
HDAC10, IC50: 40 nM
 
HDAC1, IC50: 49 nM
HDAC2, IC50: 96 nM
HDAC3, IC50: 43 nM
HDAC4, IC50: 56 nM
HDAC5, IC50: 47 nM
HDAC6, IC50: 1008 nM
HDAC7, IC50: 137 nM
HDAC8, IC50: 140 nM
HDAC9, IC50: 70 nM
HDAC11, IC50: 93 nM
    Pan Inhibitor 99.07%
Givinostat hydrochloride monohydrate
hHDAC10, IC50: 340 nM
 
hHDAC1, IC50: 198 nM
hHDAC2, IC50: 325 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC6, IC50: 315 nM
hHDAC7, IC50: 524 nM
hHDAC8, IC50: 854 nM
hHDAC9, IC50: 541 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
Pan Inhibitor >98.0%
CUDC-101
HDAC10, IC50: 26.1 nM
HDAC, IC50: 4.4 nM
HDAC1, IC50: 4.5 nM
HDAC2, IC50: 12.6 nM
HDAC3, IC50: 9.1 nM
HDAC4, IC50: 13.2 nM
HDAC5, IC50: 11.4 nM
HDAC6, IC50: 5.1 nM
HDAC7, IC50: 373 nM
HDAC8, IC50: 79.8 nM
HDAC9, IC50: 67.2 nM
      Pan Inhibitor 99.59%
Domatinostat tosylate
HDAC-10, IC50: 21 μM
 
HDAC-1, IC50: 1.2 μM
HDAC-2, IC50: 1.12 μM
HDAC-3, IC50: 0.57 μM
 
HDAC-5, IC50: 11.3 μM
     
HDAC-9, IC50: 50 μM
HDAC-11, IC50: 9.7 μM
    Pan Inhibitor 98.81%
EDO-S101
HDAC10, IC50: 72 nM
 
HDAC1, IC50: 9 nM
HDAC2, IC50: 9 nM
HDAC3, IC50: 25 nM
   
HDAC6, IC50: 6 nM
 
HDAC8, IC50: 107 nM
        Pan Inhibitor 98.09%
HPOB
HDAC10, IC50: 3.0 μM
 
HDAC1, IC50: 2.9 μM
HDAC2, IC50: 4.4 μM
HDAC3/NCOR2, IC50: 1.7 μM
   
HDAC6, IC50: 0.056 μM
 
HDAC8, IC50: 2.8 μM
        Pan Inhibitor >95.0%
Domatinostat
HDAC-10, IC50: 21 μM
 
HDAC-1, IC50: 1.2 μM
HDAC-2, IC50: 1.12 μM
HDAC-3, IC50: 0.57 μM
 
HDAC-5, IC50: 11.3 μM
     
HDAC-9, IC50: 50 μM
HDAC-11, IC50: 9.7 μM
    Pan Inhibitor 98.99%
Givinostat
hHDAC10, IC50: 340 nM
 
hHDAC1, IC50: 198 nM
hHDAC2, IC50: 325 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC6, IC50: 315 nM
hHDAC7, IC50: 524 nM
hHDAC8, IC50: 854 nM
hHDAC9, IC50: 541 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
Pan Inhibitor
Bufexamac
HDAC10, Kd app: 12.3 μM
     
HDAC3, Kd app: 341 μM
   
HDAC6, Kd app: 10.7 μM
 
HDAC8, Kd app: 235 μM
        Pan Inhibitor >98.0%
UF010
HDAC10, IC50: 15.3 μM
 
HDAC1, IC50: 0.5 μM
HDAC2, IC50: 0.1 μM
HDAC3, IC50: 0.06 μM
   
HDAC6, IC50: 9.1 μM
 
HDAC8, IC50: 1.5 μM
 
HDAC11, IC50: 44.5 μM
    Pan Inhibitor 99.36%
Givinostat hydrochloride
hHDAC10, IC50: 340 nM
 
hHDAC1, IC50: 198 nM
hHDAC2, IC50: 325 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC6, IC50: 315 nM
hHDAC7, IC50: 524 nM
hHDAC8, IC50: 854 nM
hHDAC9, IC50: 541 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
Pan Inhibitor