1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC

Tubacin 

Cat. No.: HY-13428 Purity: 98.87%
Data Sheet SDS Handling Instructions

Tubacin is a histone deacetylase 6 (HDAC6) inhibitor, blocks sphingolipid synthesis.

For research use only. We do not sell to patients.
Tubacin Chemical Structure

Tubacin Chemical Structure

CAS No. : 537049-40-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO $429 In-stock
1 mg $80 In-stock
5 mg $270 In-stock
10 mg $510 In-stock
20 mg $970 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Tubacin is a histone deacetylase 6 (HDAC6) inhibitor, blocks sphingolipid synthesis. (1) The reference concentration of tubacin is 10 uM. (2) Tubacin increase cytotoxicity of PrP106-126 by inhibiting histone deacetylase activity of HDAC6. (3) Tubacin slow the growth of metastatic prostate cancer cells and sensitize cancer cells to chemotherapeutic agents. Tubacin may therefore slow cancer cell proliferation by decreasing autophagic. (4) Tubacin treatment significantly contributed to enhanced microtubule acetylation in cells. (5) Inhibition of HDAC6 activity significantly suppress SDF-1α induced cell shape elongation and cell adhesion, thereby leading to impaired cell motility without affecting cell proliferation.

References
Molecular Weight

721.86

Formula

C₄₁H₄₃N₃O₇S

CAS No.

537049-40-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Tubacin
Cat. No.:
HY-13428
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