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Tubacin

25 Cited Publications
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Based on 25 publication(s) in Google Scholar

Tubacin is a potent and selective inhibitor of HDAC6, with an IC50 value of 4 nM and approximately 350-fold selectivity over HDAC1. Tubacin also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2).

For research use only. We do not sell to patients.

  • Purity: 97.11%
  • CAS No.: 537049-40-4
  • Formula: C41H43N3O7S
  • Molecular Weight:721.86
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Tubacin Chemical Structure
    Tubacin Chemical Structure
  • Experimental Validation Results for Tubacin
  • Experimental Validation Results for Tubacin
  • Experimental Validation Results for Tubacin
  • Experimental Validation Results for Tubacin
  • Experimental Validation Results for Tubacin
  • Experimental Validation Results for Tubacin
  • Experimental Validation Results for Tubacin
  • Experimental Validation Results for Tubacin
CAS No.: 537049-40-4
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609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Cell Imaging/StainingCell Proliferation/Viability AssayFlow CytometryIFWB
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  • Tubacin Chemical Structure
    Tubacin Chemical Structure
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    Tubacin purchased from MedChemExpress. Usage Cited in: Biomark Res. 2025 Apr 7;13(1):57. [Abstract]

    Customer Validation
     Heatmap showing the combination index (CI) values of I3MO and Tubacin (Tub, 3.125-25 μM) in MM cell lines. The cells were treated with various combinations of I3MO and Tub at different doses, and the CI values were calculated using the Chou-Talalay method. The heatmap color scale represents the CI values (indicated on the graph), with red indicating synergistic effect (CI < 1.0).

  • 1/16

    Tubacin purchased from MedChemExpress. Usage Cited in: Biomark Res. 2025 Apr 7;13(1):57. [Abstract]

    Customer Validation
     Flow cytometry histogram showing the level of aggresome in MM cell lines ARP1 and U266 after treatment with DMSO control and I3MO (10 μM) and Tubacin (10 μM) for 6 h. Bar plots showing the mean fluorescence intensity (MFI) in corresponding cell lines and conditions.

  • 1/16

    Tubacin purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Oct 3;23(1):417. [Abstract]

    Customer Validation
     Representative light microscopy images showing oocytes in control, DON, and DON + Tubacin (2-6 μM) oocytes. Scale bar, 200 μm. Quantification of the percentage of oocytes that undergo PBE in vitro.

  • 1/16

    Tubacin purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Oct 3;23(1):417. [Abstract]

    Customer Validation
     Representative light microscopy images showing oocytes in control, DON, and DON + Tubacin (4 μM) oocytes. Scale bar, 200 μm. C Quantification of the percentage of oocytes that undergo PBE in vitro.

  • 1/16

    Tubacin purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Oct 3;23(1):417. [Abstract]

    Customer Validation
     Representative immunofluorescence images demonstrating spindle assembly in mouse metaphase I oocytes from control, DON, and DON + Tubacin (4 μM). Green, microtubule (β-Tubulin); red, aMTOCs (γ-Tubulin); blue, DNA (DAPI). Scale bar, 10 μm.

  • 1/16

    Tubacin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2021 Jan 28;12(1):662. [Abstract]

    Customer Validation
     Quantification of cilium length of Ki67+ cells in Sox2-positive RG cells. Isolated cells from Lpar1+/+ cerebral cortex were treated with 2 μM tubacin or DMSO for 72 h, and isolated cells from Lpar1−/− cerebral cortex were infected with lentivirus expressed GFP or GFP-Lpar1 with or without 2 μM tubacin treatment for 72 h.

  • 1/16

    Tubacin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2021 Jan 28;12(1):662. [Abstract]

    Customer Validation
     Percentage of Ki67+ cells in Sox2-positive RG cells. Isolated cells from Lpar1+/+ cerebral cortex were treated with 2 μM tubacin or DMSO for 72 h, and isolated cells from Lpar1−/− cerebral cortex were infected with lentivirus expressed GFP or GFP-Lpar1 with or without 2 μM tubacin treatment for 72 h.

  • 1/16

    Tubacin purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2019 Jun:114:108805. [Abstract]

    Customer Validation
     Western blot is used for the detection of VEGFA and Hsp-90 with or without the treatment of Tubacin.

  • Tubacin