1. Signaling Pathways
  2. Cell Cycle/DNA Damage
    Epigenetics
  3. HDAC
  4. HDAC8 Inhibitors

HDAC8 Inhibitors

HDAC

HDAC1

HDAC2

HDAC3

HDAC4

HDAC5

HDAC6

HDAC7

HDAC8

HDAC9

HDAC10

HDAC11

HD1

HD2

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Sorry. There is currently no product that acts on isoform HDAC8 together.

Please try each isoform separately.

HDAC8 Specific Inhibitors
Product Name HDAC8 HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDAC10 HDAC11 HD1 HD2 HDAC8 Selectivity Purity
PCI-34051
HDAC8, IC50: 10 nM
 
HDAC1, IC50: 4 μM
       
HDAC6, IC50: 2.9 μM
   
HDAC10, IC50: 13 μM
      Selective Inhibitor 99.38%
HDAC8-IN-1
HDAC8, IC50: 27.2 nM
                          Selective Inhibitor 99.82%
1-Naphthohydroxamic acid
HDAC8, IC50: 14 μM
 
HDAC1, IC50: >100 μM
       
HDAC6, IC50: >100 μM
            Selective Inhibitor ≥98.0%
KA2507
HDAC8, IC50: 621
           
HDAC6, IC50: 2.5 nM
            Pan Inhibitor 98.09%
Tucidinostat
HDAC8, IC50: 733 nM
 
HDAC1, IC50: 95 nM
HDAC2, IC50: 160 nM
HDAC3, IC50: 67 nM
         
HDAC10, IC50: 78 nM
HDAC11, IC50: 432 nM
    Pan Inhibitor ≥98.0%
Ricolinostat
HDAC8, IC50: 100 nM
 
HDAC1, IC50: 58 nM
HDAC2, IC50: 48 nM
HDAC3, IC50: 51 nM
HDAC4, IC50: 7000 nM
HDAC5, IC50: 5000 nM
HDAC6, IC50: 4.7 nM
HDAC7, IC50: 1400 nM
          Pan Inhibitor ≥95.0%
Tubastatin A
HDAC8, IC50: 854 nM
 
HDAC1, IC50: 16400 nM
       
HDAC6, IC50: 15 nM
            Pan Inhibitor ≥98.0%
Fimepinostat
HDAC8, IC50: 191 nM
 
HDAC1, IC50: 1.7 nM
HDAC2, IC50: 5 nM
HDAC3, IC50: 1.8 nM
HDAC4, IC50: 409 nM
HDAC5, IC50: 674 nM
HDAC6, IC50: 27 nM
HDAC7, IC50: 426 nM
HDAC9, IC50: 554 nM
HDAC10, IC50: 2.8 nM
HDAC11, IC50: 5.4 nM
    Pan Inhibitor 99.95%
TMP195
HDAC8, IC50: 11700 nM
       
HDAC4, IC50: 111 nM
HDAC5, IC50: 106 nM
HDAC6, IC50: 47800 nM
HDAC7, IC50: 46 nM
HDAC9, IC50: 9 nM
        Pan Inhibitor 99.68%
Quisinostat
HDAC8, IC50: 4.26 nM
 
HDAC1, IC50: 0.11 nM
HDAC2, IC50: 0.33 nM
HDAC3, IC50: 4.86 nM
HDAC4, IC50: 0.64 nM
HDAC5, IC50: 3.69 nM
HDAC6, IC50: 76.8 nM
HDAC7, IC50: 119 nM
HDAC9, IC50: 32.1 nM
HDAC10, IC50: 0.46 nM
HDAC11, IC50: 0.37 nM
    Pan Inhibitor 98.02%
TMP269
HDAC8, IC50: 42000 nM
       
HDAC4, IC50: 157 nM
HDAC5, IC50: 97 nM
HDAC6, IC50: 82000 nM
HDAC7, IC50: 43 nM
HDAC9, IC50: 23 nM
        Pan Inhibitor 98.23%
Tubacin
HDAC8, IC50: 1.27 μM
 
HDAC1, IC50: 1.40 μM
HDAC2, IC50: 6.27 μM
HDAC3, IC50: 1.27 μM
HDAC4, IC50: 17.30 μM
HDAC5, IC50: 3.35 μM
HDAC6, IC50: 4 nM
HDAC7, IC50: 9.70 μM
HDAC9, IC50: 4.31 μM
HDAC10, IC50: 3.71 μM
HDAC11, IC50: 3.79 μM
    Pan Inhibitor ≥95.0%
CUDC-101
HDAC8, IC50: 79.8 nM
HDAC, IC50: 4.4 nM
HDAC1, IC50: 4.5 nM
HDAC2, IC50: 12.6 nM
HDAC3, IC50: 9.1 nM
HDAC4, IC50: 13.2 nM
HDAC5, IC50: 11.4 nM
HDAC6, IC50: 5.1 nM
HDAC7, IC50: 373 nM
HDAC9, IC50: 67.2 nM
HDAC10, IC50: 26.1 nM
      Pan Inhibitor 99.19%
Tubastatin A Hydrochloride
HDAC8, IC50: 854 nM
 
HDAC1, IC50: 16400 nM
       
HDAC6, IC50: 15 nM
            Pan Inhibitor ≥95.0%
Pracinostat
HDAC8, IC50: 140 nM
 
HDAC1, IC50: 49 nM
HDAC2, IC50: 96 nM
HDAC3, IC50: 43 nM
HDAC4, IC50: 56 nM
HDAC5, IC50: 47 nM
HDAC6, IC50: 1008 nM
HDAC7, IC50: 137 nM
HDAC9, IC50: 70 nM
HDAC10, IC50: 40 nM
HDAC11, IC50: 93 nM
    Pan Inhibitor 99.82%
Abexinostat
HDAC8, Ki: 280 nM
 
HDAC1, Ki: 7 nM
HDAC2, Ki: 19 nM
HDAC3/SMRT, Ki: 8.2 nM
   
HDAC6, Ki: 17 nM
   
HDAC10, Ki: 24 nM
      Pan Inhibitor 98.61%
Nexturastat A
HDAC8, IC50: 0.954 μM
 
HDAC1, IC50: 3.02 μM
HDAC2, IC50: 6.92 μM
HDAC3, IC50: 6.68 μM
HDAC4, IC50: 9.39 μM
HDAC5, IC50: 11.7 μM
HDAC6, IC50: 5.02 nM
HDAC7, IC50: 4.46 μM
HDAC9, IC50: 6.72 μM
HDAC10, IC50: 7.57 μM
HDAC11, IC50: 5.14 μM
    Pan Inhibitor 98.49%
CAY10603
HDAC8, IC50: 6851 nM
 
HDAC1, IC50: 271 nM
HDAC2, IC50: 252 nM
HDAC3, IC50: 0.42 nM
   
HDAC6, IC50: 0.002 nM
   
HDAC10, IC50: 90.7 nM
      Pan Inhibitor 95.39%
Givinostat hydrochloride monohydrate
hHDAC8, IC50: 854 nM
 
hHDAC1, IC50: 198 nM
hHDAC2, IC50: 325 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC6, IC50: 315 nM
hHDAC7, IC50: 524 nM
hHDAC9, IC50: 541 nM
hHDAC10, IC50: 340 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
Pan Inhibitor ≥98.0%
WT-161
HDAC8, IC50: 1430 nM
 
HDAC1, IC50: 8.35 nM
HDAC2, IC50: 15.4 nM
HDAC3, IC50: 51.6 nM
   
HDAC6, IC50: 0.4 nM
            Pan Inhibitor 98.52%
SW-100
HDAC8, IC50: 3.72 μM
 
HDAC1, IC50: 5.23 μM
HDAC2, IC50: 32.8 μM
HDAC3, IC50: 29.5 μM
HDAC4, IC50: 10.9 μM
HDAC5, IC50: 4.07 μM
HDAC6, IC50: 2.3 nM
HDAC7, IC50: 4.55 μM
HDAC9, IC50: 3.46 μM
HDAC10, IC50: 26.2 μM
HDAC11, IC50: 5.72 μM
    Pan Inhibitor 99.92%
Citarinostat
HDAC8, IC50: 137 nM
 
HDAC1, IC50: 35 nM
HDAC2, IC50: 45 nM
HDAC3, IC50: 46 nM
   
HDAC6, IC50: 2.6 nM
HDAC7, IC50: 7300 nM
          Pan Inhibitor ≥95.0%
EDO-S101
HDAC8, IC50: 107 nM
 
HDAC1, IC50: 9 nM
HDAC2, IC50: 9 nM
HDAC3, IC50: 25 nM
   
HDAC6, IC50: 6 nM
   
HDAC10, IC50: 72 nM
      Pan Inhibitor ≥98.0%
JAK/HDAC-IN-1
HDAC8, IC50: 2470 nM
HDAC, IC50: 2 nM
 
HDAC2, IC50: 14 nM
     
HDAC6, IC50: 120 nM
            Pan Inhibitor 98.04%
Bufexamac
HDAC8, Kd app: 235 μM
     
HDAC3, Kd app: 341 μM
   
HDAC6, Kd app: 10.7 μM
   
HDAC10, Kd app: 12.3 μM
      Pan Inhibitor ≥98.0%
Resminostat hydrochloride
HDAC8, IC50: 877 nM
 
HDAC1, IC50: 42.5 nM
 
HDAC3, IC50: 50.1 nM
   
HDAC6, IC50: 71.8 nM
            Pan Inhibitor 99.12%
Droxinostat
HDAC8, IC50: 1.46 μM
     
HDAC3, IC50: 16.9 μM
   
HDAC6, IC50: 2.47 μM
            Pan Inhibitor 99.60%
UF010
HDAC8, IC50: 1.5 μM
 
HDAC1, IC50: 0.5 μM
HDAC2, IC50: 0.1 μM
HDAC3, IC50: 0.06 μM
   
HDAC6, IC50: 9.1 μM
   
HDAC10, IC50: 15.3 μM
HDAC11, IC50: 44.5 μM
    Pan Inhibitor 99.08%
Pimelic Diphenylamide 106
HDAC8, IC50: 5000 nM
 
HDAC1, IC50: 150 nM
HDAC2, IC50: 760 nM
HDAC3, IC50: 370 nM
                  Pan Inhibitor ≥98.0%
TH34
HDAC8, IC50: 1.9 μM
           
HDAC6, IC50: 4.6 μM
   
HDAC10, IC50: 7.7 μM
      Pan Inhibitor 99.05%
HPOB
HDAC8, IC50: 2.8 μM
 
HDAC1, IC50: 2.9 μM
HDAC2, IC50: 4.4 μM
HDAC3/NCOR2, IC50: 1.7 μM
   
HDAC6, IC50: 0.056 μM
   
HDAC10, IC50: 3.0 μM
      Pan Inhibitor ≥95.0%
SR-4370
HDAC8, IC50: 2300 nM
 
HDAC1, IC50: 130 nM
HDAC2, IC50: 580 nM
HDAC3, IC50: 6 nM
   
HDAC6, IC50: 3400 nM
            Pan Inhibitor 98.03%
BRD73954
HDAC8, IC50: 0.12 μM
   
HDAC2, IC50: 9 μM
     
HDAC6, IC50: 0.036 μM
            Pan Inhibitor ≥98.0%
CHDI-390576
HDAC8, IC50: 9.1 μM
 
HDAC1, IC50: 39.7 μM
 
HDAC3, IC50: 25.8 μM
HDAC4, IC50: 54 nM
HDAC5, IC50: 60 nM
hHDAC6, IC50: 6.2 μM
HDAC7, IC50: 31 nM
hHDAC9, IC50: 50 nM
        Pan Inhibitor ≥98.0%
SS-208
HDAC8, IC50: 1.23 μM
 
HDAC1, IC50: 1.39 μM
     
HDAC5, IC50: 6.91 μM
HDAC6, IC50: 12 nM
HDAC7, IC50: 8.34 μM
   
HDAC11, IC50: 5.12 μM
    Pan Inhibitor 98.13%
AES-135
HDAC8, IC50: 1100 nM
     
HDAC3, IC50: 654 nM
   
HDAC6, IC50: 190 nM
     
HDAC11, IC50: 636 nM
    Pan Inhibitor 98.31%
FNDR-20123
HDAC8, IC50: 282 nM
human HDAC, IC50: 3 nM
Plasmodium HDAC, IC50: 31 nM
HDAC1, IC50: 25 nM
HDAC2, IC50: 29 nM
HDAC3, IC50: 2 nM
   
HDAC6, IC50: 11 nM
            Pan Inhibitor 98.08%
Givinostat
hHDAC8, IC50: 854 nM
 
hHDAC1, IC50: 198 nM
hHDAC2, IC50: 325 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC6, IC50: 315 nM
hHDAC7, IC50: 524 nM
hHDAC9, IC50: 541 nM
hHDAC10, IC50: 340 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
Pan Inhibitor
NKL 22
HDAC8, IC50: 5 μM
 
HDAC1, IC50: 0.199 μM
HDAC2, IC50: 1.59 μM
HDAC3, IC50: 0.069 μM
                  Pan Inhibitor 97.97%
Resminostat
HDAC8, IC50: 877 nM
 
HDAC1, IC50: 42.5 nM
 
HDAC3, IC50: 50.1 nM
   
HDAC6, IC50: 71.8 nM
            Pan Inhibitor
Quisinostat dihydrochloride
HDAC8, IC50: 4.26 nM
 
HDAC1, IC50: 0.11 nM
HDAC2, IC50: 0.33 nM
HDAC3, IC50: 4.86 nM
 
HDAC5, IC50: 3.69 nM
HDAC6, IC50: 76.8 nM
HDAC7, IC50: 119 nM
HDAC9, IC50: 32.1 nM
HDAC10, IC50: 0.46 nM
HDAC11, IC50: 0.37 nM
    Pan Inhibitor
MPT0E028
HDAC8, IC50: 2532.6 nM
 
HDAC1, IC50: 53.0 nM
HDAC2, IC50: 106.2 nM
     
HDAC6, IC50: 29.5 nM
            Pan Inhibitor
PI3K/HDAC-IN-1
HDAC8, IC50: 18 nM
 
HDAC1, IC50: 1.4 nM
HDAC2, IC50: 3.0 nM
     
HDAC6, IC50: 6.6 nM
            Pan Inhibitor
FNDR-20123 free base
HDAC8, IC50: 282 nM
human HDAC, IC50: 3 nM
Plasmodium HDAC, IC50: 31 nM
HDAC1, IC50: 25 nM
HDAC2, IC50: 29 nM
HDAC3, IC50: 2 nM
   
HDAC6, IC50: 11 nM
            Pan Inhibitor
Givinostat hydrochloride
hHDAC8, IC50: 854 nM
 
hHDAC1, IC50: 198 nM
hHDAC2, IC50: 325 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC6, IC50: 315 nM
hHDAC7, IC50: 524 nM
hHDAC9, IC50: 541 nM
hHDAC10, IC50: 340 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
Pan Inhibitor
CRA-026440
HDAC8, Ki: 7 nM
 
HDAC1, Ki: 4 nM
HDAC2, Ki: 14 nM
HDAC3, Ki: 11 nM
   
HDAC6, Ki: 15 nM
   
HDAC10, Ki: 20 nM
      Pan Inhibitor