1. Signaling Pathways
  2. Cell Cycle/DNA Damage
    Epigenetics
  3. HDAC
  4. HDAC8 Inhibitors

HDAC8 Inhibitors

HDAC

HDAC1

HDAC2

HDAC3

HDAC4

HDAC5

HDAC6

HDAC7

HDAC8

HDAC9

HDAC10

HDAC11

HD1

HD2

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Sorry. There is currently no product that acts on isoform HDAC8 together.

Please try each isoform separately.

HDAC8 Specific Inhibitors
Product Name HDAC8 HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDAC10 HDAC11 HD1 HD2 HDAC8 Selectivity Purity
HDAC8-IN-1
HDAC8, IC50: 27.2 nM
                          Selective Inhibitor 99.59%
SW-100
HDAC8, IC50: 3.72 μM
 
HDAC1, IC50: 5.23 μM
HDAC2, IC50: 32.8 μM
HDAC3, IC50: 29.5 μM
HDAC4, IC50: 10.9 μM
HDAC5, IC50: 4.07 μM
HDAC6, IC50: 2.3 nM
HDAC7, IC50: 4.55 μM
HDAC9, IC50: 3.46 μM
HDAC10, IC50: 26.2 μM
HDAC11, IC50: 5.72 μM
    Pan Inhibitor 99.92%
Ricolinostat
HDAC8, IC50: 100 nM
 
HDAC1, IC50: 58 nM
HDAC2, IC50: 48 nM
HDAC3, IC50: 51 nM
HDAC4, IC50: 7000 nM
HDAC5, IC50: 5000 nM
HDAC6, IC50: 4.7 nM
HDAC7, IC50: 1400 nM
          Pan Inhibitor 99.70%
Fimepinostat
HDAC8, IC50: 191 nM
 
HDAC1, IC50: 1.7 nM
HDAC2, IC50: 5 nM
HDAC3, IC50: 1.8 nM
HDAC4, IC50: 409 nM
HDAC5, IC50: 674 nM
HDAC6, IC50: 27 nM
HDAC7, IC50: 426 nM
HDAC9, IC50: 554 nM
HDAC10, IC50: 2.8 nM
HDAC11, IC50: 5.4 nM
    Pan Inhibitor 99.95%
Tubacin
HDAC8, IC50: 1.27 μM
 
HDAC1, IC50: 1.40 μM
HDAC2, IC50: 6.27 μM
HDAC3, IC50: 1.27 μM
HDAC4, IC50: 17.30 μM
HDAC5, IC50: 3.35 μM
HDAC6, IC50: 4 nM
HDAC7, IC50: 9.70 μM
HDAC9, IC50: 4.31 μM
HDAC10, IC50: 3.71 μM
HDAC11, IC50: 3.79 μM
    Pan Inhibitor 98.87%
TMP195
HDAC8, IC50: 11700 nM
       
HDAC4, IC50: 111 nM
HDAC5, IC50: 106 nM
HDAC6, IC50: 47800 nM
HDAC7, IC50: 46 nM
HDAC9, IC50: 9 nM
        Pan Inhibitor 99.42%
Tubastatin A
HDAC8, IC50: 854 nM
 
HDAC1, IC50: 16400 nM
       
HDAC6, IC50: 15 nM
            Pan Inhibitor >98.0%
Tubastatin A Hydrochloride
HDAC8, IC50: 854 nM
 
HDAC1, IC50: 16400 nM
       
HDAC6, IC50: 15 nM
            Pan Inhibitor 98.31%
Nexturastat A
HDAC8, IC50: 0.954 μM
 
HDAC1, IC50: 3.02 μM
HDAC2, IC50: 6.92 μM
HDAC3, IC50: 6.68 μM
HDAC4, IC50: 9.39 μM
HDAC5, IC50: 11.7 μM
HDAC6, IC50: 5.02 nM
HDAC7, IC50: 4.46 μM
HDAC9, IC50: 6.72 μM
HDAC10, IC50: 7.57 μM
HDAC11, IC50: 5.14 μM
    Pan Inhibitor 97.92%
Abexinostat
HDAC8, Ki: 280 nM
 
HDAC1, Ki: 7 nM
HDAC2, Ki: 19 nM
HDAC3/SMRT, Ki: 8.2 nM
   
HDAC6, Ki: 17 nM
   
HDAC10, Ki: 24 nM
      Pan Inhibitor 98.61%
Pracinostat
HDAC8, IC50: 140 nM
 
HDAC1, IC50: 49 nM
HDAC2, IC50: 96 nM
HDAC3, IC50: 43 nM
HDAC4, IC50: 56 nM
HDAC5, IC50: 47 nM
HDAC6, IC50: 1008 nM
HDAC7, IC50: 137 nM
HDAC9, IC50: 70 nM
HDAC10, IC50: 40 nM
HDAC11, IC50: 93 nM
    Pan Inhibitor 99.07%
CAY10603
HDAC8, IC50: 6851 nM
 
HDAC1, IC50: 271 nM
HDAC2, IC50: 252 nM
HDAC3, IC50: 0.42 nM
   
HDAC6, IC50: 0.002 nM
   
HDAC10, IC50: 90.7 nM
      Pan Inhibitor 95.39%
Givinostat hydrochloride monohydrate
hHDAC8, IC50: 854 nM
 
hHDAC1, IC50: 198 nM
hHDAC2, IC50: 325 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC6, IC50: 315 nM
hHDAC7, IC50: 524 nM
hHDAC9, IC50: 541 nM
hHDAC10, IC50: 340 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
Pan Inhibitor >98.0%
CUDC-101
HDAC8, IC50: 79.8 nM
HDAC, IC50: 4.4 nM
HDAC1, IC50: 4.5 nM
HDAC2, IC50: 12.6 nM
HDAC3, IC50: 9.1 nM
HDAC4, IC50: 13.2 nM
HDAC5, IC50: 11.4 nM
HDAC6, IC50: 5.1 nM
HDAC7, IC50: 373 nM
HDAC9, IC50: 67.2 nM
HDAC10, IC50: 26.1 nM
      Pan Inhibitor 99.59%
Citarinostat
HDAC8, IC50: 137 nM
 
HDAC1, IC50: 35 nM
HDAC2, IC50: 45 nM
HDAC3, IC50: 46 nM
   
HDAC6, IC50: 2.6 nM
HDAC7, IC50: 7300 nM
          Pan Inhibitor 99.06%
EDO-S101
HDAC8, IC50: 107 nM
 
HDAC1, IC50: 9 nM
HDAC2, IC50: 9 nM
HDAC3, IC50: 25 nM
   
HDAC6, IC50: 6 nM
   
HDAC10, IC50: 72 nM
      Pan Inhibitor 98.09%
HPOB
HDAC8, IC50: 2.8 μM
 
HDAC1, IC50: 2.9 μM
HDAC2, IC50: 4.4 μM
HDAC3/NCOR2, IC50: 1.7 μM
   
HDAC6, IC50: 0.056 μM
   
HDAC10, IC50: 3.0 μM
      Pan Inhibitor >95.0%
SR-4370
HDAC8, IC50: 2300 nM
 
HDAC1, IC50: 130 nM
HDAC2, IC50: 580 nM
HDAC3, IC50: 6 nM
   
HDAC6, IC50: 3400 nM
            Pan Inhibitor 98.33%
Bufexamac
HDAC8, Kd app: 235 μM
     
HDAC3, Kd app: 341 μM
   
HDAC6, Kd app: 10.7 μM
   
HDAC10, Kd app: 12.3 μM
      Pan Inhibitor >98.0%
Droxinostat
HDAC8, IC50: 1.46 μM
     
HDAC3, IC50: 16.9 μM
   
HDAC6, IC50: 2.47 μM
            Pan Inhibitor 98.86%
Givinostat
hHDAC8, IC50: 854 nM
 
hHDAC1, IC50: 198 nM
hHDAC2, IC50: 325 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC6, IC50: 315 nM
hHDAC7, IC50: 524 nM
hHDAC9, IC50: 541 nM
hHDAC10, IC50: 340 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
Pan Inhibitor
Pimelic Diphenylamide 106
HDAC8, IC50: 5000 nM
 
HDAC1, IC50: 150 nM
HDAC2, IC50: 760 nM
HDAC3, IC50: 370 nM
                  Pan Inhibitor >98.0%
JAK/HDAC-IN-1
HDAC8, IC50: 2470 nM
HDAC, IC50: 2 nM
 
HDAC2, IC50: 14 nM
     
HDAC6, IC50: 120 nM
            Pan Inhibitor 98.04%
Resminostat
HDAC8, IC50: 877 nM
 
HDAC1, IC50: 42.5 nM
 
HDAC3, IC50: 50.1 nM
   
HDAC6, IC50: 71.8 nM
            Pan Inhibitor
BRD73954
HDAC8, IC50: 0.12 μM
   
HDAC2, IC50: 9 μM
     
HDAC6, IC50: 0.036 μM
            Pan Inhibitor >98.0%
UF010
HDAC8, IC50: 1.5 μM
 
HDAC1, IC50: 0.5 μM
HDAC2, IC50: 0.1 μM
HDAC3, IC50: 0.06 μM
   
HDAC6, IC50: 9.1 μM
   
HDAC10, IC50: 15.3 μM
HDAC11, IC50: 44.5 μM
    Pan Inhibitor 99.36%
MPT0E028
HDAC8, IC50: 2532.6 nM
 
HDAC1, IC50: 53.0 nM
HDAC2, IC50: 106.2 nM
     
HDAC6, IC50: 29.5 nM
            Pan Inhibitor
CHDI-390576
HDAC8, IC50: 9.1 μM
 
HDAC1, IC50: 39.7 μM
 
HDAC3, IC50: 25.8 μM
HDAC4, IC50: 54 nM
HDAC5, IC50: 60 nM
hHDAC6, IC50: 6.2 μM
HDAC7, IC50: 31 nM
hHDAC9, IC50: 50 nM
        Pan Inhibitor
PI3K/HDAC-IN-1
HDAC8, IC50: 18 nM
 
HDAC1, IC50: 1.4 nM
HDAC2, IC50: 3.0 nM
     
HDAC6, IC50: 6.6 nM
            Pan Inhibitor
TH34
HDAC8, IC50: 1.9 μM
           
HDAC6, IC50: 4.6 μM
   
HDAC10, IC50: 7.7 μM
      Pan Inhibitor 99.05%
Givinostat hydrochloride
hHDAC8, IC50: 854 nM
 
hHDAC1, IC50: 198 nM
hHDAC2, IC50: 325 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC6, IC50: 315 nM
hHDAC7, IC50: 524 nM
hHDAC9, IC50: 541 nM
hHDAC10, IC50: 340 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
Pan Inhibitor
CRA-026440
HDAC8, Ki: 7 nM
 
HDAC1, Ki: 4 nM
HDAC2, Ki: 14 nM
HDAC3, Ki: 11 nM
   
HDAC6, Ki: 15 nM
   
HDAC10, Ki: 20 nM
      Pan Inhibitor