2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Epigenetics
  4. HDAC
  5. HDAC8 Isoform

HDAC8

 

HDAC8 Related Products (96):

Cat. No. Product Name Effect Purity
  • HY-109015
    Tucidinostat
    		Inhibitor 99.82%
    Tucidinostat (Chidamide) is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC50s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9.
  • HY-16026
    Ricolinostat
    		Inhibitor 99.83%
    Ricolinostat (ACY-1215) is a potent and selective HDAC6 inhibitor, with an IC50 of 5 nM.
  • HY-13271A
    Tubastatin A
    		Inhibitor 98.37%
    Tubastatin A is a potent and selective HDAC6 inhibitor with an IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more).
  • HY-18361
    TMP195
    		Inhibitor 99.19%
    TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor with an IC50 of 300 nM.
  • HY-18360
    TMP269
    		Inhibitor 98.23%
    TMP269 is a novel and selective class IIa histone deacetylase (HDAC) inhibitor with IC50s of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.
  • HY-117554
    BRD9757
    		Inhibitor
    BRD9757 is a potent, capless and selective HDAC6 inhibitor with an IC50 of 30 nM.
  • HY-152226
    MC2590
    		Inhibitor
    MC2590 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor.
  • HY-152225
    MC2625
    		Inhibitor
    MC2625 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor.
  • HY-13522
    Fimepinostat
    		Inhibitor 99.95%
    Fimepinostat (CUDC-907) potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes with an IC50 of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10 , respectively.
  • HY-15433
    Quisinostat
    		Inhibitor 98.02%
    Quisinostat (JNJ-26481585) is a potent, second-generation and orally active pan-HDAC inhibitor (HDACi), with IC50 values ranging from 0.11 nM to 0.64 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11.
  • HY-13428
    Tubacin
    		Inhibitor
    Tubacin is a potent and selective inhibitor of HDAC6, with an IC50 value of 4 nM and approximately 350-fold selectivity over HDAC1.
  • HY-15224
    PCI-34051
    		Inhibitor 99.64%
    PCI-34051 is a potent and selective HDAC8 inhibitor with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms.
  • HY-13322
    Pracinostat
    		Inhibitor 99.82%
    Pracinostat is a potent histone deacetylase (HDAC) inhibitor, with IC50s of 40-140 nM, used for cancer research.
  • HY-13271
    Tubastatin A Hydrochloride
    		Inhibitor 98.21%
    Tubastatin A Hydrochloride (Tubastatin A HCl) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more).
  • HY-10223
    CUDC-101
    		Inhibitor 99.19%
    CUDC-101 is a potent inhibitor of HDAC, EGFR, and HER2 with IC50s of 4.4, 2.4, and 15.7 nM, respectively.
  • HY-10990
    Abexinostat
    		Inhibitor 98.61%
    Abexinostat (CRA 024781) is a novel pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM.
  • HY-18613
    CAY10603
    		Inhibitor 99.62%
    CAY10603 (BML-281) is a potent and selective HDAC6 inhibitor, with an IC50 of 2 pM; CAY10603 (BML-281) also inhibits HDAC1, HDAC2, HDAC3, HDAC8, HDAC10, with IC50s of 271, 252, 0.42, 6851, 90.7 nM.
  • HY-16699
    Nexturastat A
    		Inhibitor 99.03%
    Nexturastat A is a potent, selective HDAC6 inhibitor.
  • HY-14842B
    Givinostat hydrochloride monohydrate
    		Inhibitor ≥98.0%
    Givinostat hydrochloride monohydrate (ITF-2357 hydrochloride monohydrate) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.
  • HY-111342
    HDAC8-IN-1
    		Inhibitor 99.82%
    HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM.