1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. Citarinostat

Citarinostat (Synonyms: ACY241)

Cat. No.: HY-15994 Purity: 99.02%
Handling Instructions

Citarinostat (ACY241) is a specific HDAC6 inhibitor, with IC50s of 4 nM and 76 nM for HDAC6 and HDAC3, respectively.The detailed information please refer to WO2015061684A1 and 2015054197A1.

For research use only. We do not sell to patients.

Citarinostat Chemical Structure

Citarinostat Chemical Structure

CAS No. : 1316215-12-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 154 In-stock
Estimated Time of Arrival: December 31
5 mg USD 140 In-stock
Estimated Time of Arrival: December 31
10 mg USD 220 In-stock
Estimated Time of Arrival: December 31
50 mg USD 810 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Citarinostat (ACY241) is a specific HDAC6 inhibitor, with IC50s of 4 nM and 76 nM for HDAC6 and HDAC3, respectively.The detailed information please refer to WO2015061684A1 and 2015054197A1.

IC50 & Target[1]

HDAC6

2.6 nM (IC50)

HDAC1

35 nM (IC50)

HDAC2

45 nM (IC50)

HDAC3

46 nM (IC50)

HDAC8

137 nM (IC50)

HDAC7

7300 nM (IC50)

Clinical Trial
Molecular Weight

467.95

Formula

C₂₄H₂₆ClN₅O₃

CAS No.

1316215-12-9

SMILES

O=C(C1=CN=C(N(C2=CC=CC=C2Cl)C3=CC=CC=C3)N=C1)NCCCCCCC(NO)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (64.11 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1370 mL 10.6849 mL 21.3698 mL
5 mM 0.4274 mL 2.1370 mL 4.2740 mL
10 mM 0.2137 mL 1.0685 mL 2.1370 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.34 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.34 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.34 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Citarinostat
Cat. No.:
HY-15994
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