1. Signaling Pathways
  2. Cell Cycle/DNA Damage
    Epigenetics
  3. HDAC
  4. HDAC6 Inhibitors

HDAC6 Inhibitors

HDAC

HDAC1

HDAC2

HDAC3

HDAC4

HDAC5

HDAC6

HDAC7

HDAC8

HDAC9

HDAC10

HDAC11

HD1

HD2

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Sorry. There is currently no product that acts on isoform HDAC6 together.

Please try each isoform separately.

HDAC6 Specific Inhibitors
Product Name HDAC6 HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2 HDAC6 Selectivity Purity
SW-100
HDAC6, IC50: 2.3 nM
 
HDAC1, IC50: 5.23 μM
HDAC2, IC50: 32.8 μM
HDAC3, IC50: 29.5 μM
HDAC4, IC50: 10.9 μM
HDAC5, IC50: 4.07 μM
HDAC7, IC50: 4.55 μM
HDAC8, IC50: 3.72 μM
HDAC9, IC50: 3.46 μM
HDAC10, IC50: 26.2 μM
HDAC11, IC50: 5.72 μM
    Selective Inhibitor 99.92%
Ricolinostat
HDAC6, IC50: 4.7 nM
 
HDAC1, IC50: 58 nM
HDAC2, IC50: 48 nM
HDAC3, IC50: 51 nM
HDAC4, IC50: 7000 nM
HDAC5, IC50: 5000 nM
HDAC7, IC50: 1400 nM
HDAC8, IC50: 100 nM
          Selective Inhibitor 99.70%
Tubacin
HDAC6, IC50: 4 nM
 
HDAC1, IC50: 1.40 μM
HDAC2, IC50: 6.27 μM
HDAC3, IC50: 1.27 μM
HDAC4, IC50: 17.30 μM
HDAC5, IC50: 3.35 μM
HDAC7, IC50: 9.70 μM
HDAC8, IC50: 1.27 μM
HDAC9, IC50: 4.31 μM
HDAC10, IC50: 3.71 μM
HDAC11, IC50: 3.79 μM
    Selective Inhibitor 98.87%
Tubastatin-A
HDAC6, IC50: 15 nM
 
HDAC1, IC50: 16400 nM
         
HDAC8, IC50: 854 nM
          Selective Inhibitor >98.0%
ACY-738
HDAC6, IC50: 1.7 nM
 
HDAC1, IC50: 94 nM
HDAC2, IC50: 128 nM
HDAC3, IC50: 218 nM
                  Selective Inhibitor 99.94%
Tubastatin A Hydrochloride
HDAC6, IC50: 15 nM
 
HDAC1, IC50: 16400 nM
         
HDAC8, IC50: 854 nM
          Selective Inhibitor 98.31%
Nexturastat A
HDAC6, IC50: 5.02 nM
 
HDAC1, IC50: 3.02 μM
HDAC2, IC50: 6.92 μM
HDAC3, IC50: 6.68 μM
HDAC4, IC50: 9.39 μM
HDAC5, IC50: 11.7 μM
HDAC7, IC50: 4.46 μM
HDAC8, IC50: 0.954 μM
HDAC9, IC50: 6.72 μM
HDAC10, IC50: 7.57 μM
HDAC11, IC50: 5.14 μM
    Selective Inhibitor 97.92%
ACY-775
HDAC6, IC50: 7.5 nM
 
HDAC1, IC50: 2123 nM
HDAC2, IC50: 2570 nM
HDAC3, IC50: 11223 nM
                  Selective Inhibitor 99.54%
CAY10603
HDAC6, IC50: 0.002 nM
 
HDAC1, IC50: 271 nM
HDAC2, IC50: 252 nM
HDAC3, IC50: 0.42 nM
     
HDAC8, IC50: 6851 nM
 
HDAC10, IC50: 90.7 nM
      Selective Inhibitor 95.39%
Citarinostat
HDAC6, IC50: 2.6 nM
 
HDAC1, IC50: 35 nM
HDAC2, IC50: 45 nM
HDAC3, IC50: 46 nM
   
HDAC7, IC50: 7300 nM
HDAC8, IC50: 137 nM
          Selective Inhibitor 99.06%
HPOB
HDAC6, IC50: 0.056 μM
 
HDAC1, IC50: 2.9 μM
HDAC2, IC50: 4.4 μM
HDAC3/NCOR2, IC50: 1.7 μM
     
HDAC8, IC50: 2.8 μM
 
HDAC10, IC50: 3.0 μM
      Selective Inhibitor >95.0%
ACY-1083
HDAC6, IC50: 3 nM
                          Selective Inhibitor
SS-208
HDAC6, IC50: 75 nM
                          Selective Inhibitor
J22352
HDAC6, IC50: 4.7 nM
                          Selective Inhibitor
Crotonoside
HDAC6
     
HDAC3
                  Selective Inhibitor
Romidepsin
HDAC6, IC50: 14000 nM
 
HDAC1, IC50: 36 nM
HDAC2, IC50: 47 nM
 
HDAC4, IC50: 510 nM
                Pan Inhibitor 99.98%
Fimepinostat
HDAC6, IC50: 27 nM
 
HDAC1, IC50: 1.7 nM
HDAC2, IC50: 5 nM
HDAC3, IC50: 1.8 nM
HDAC4, IC50: 409 nM
HDAC5, IC50: 674 nM
HDAC7, IC50: 426 nM
HDAC8, IC50: 191 nM
HDAC9, IC50: 554 nM
HDAC10, IC50: 2.8 nM
HDAC11, IC50: 5.4 nM
    Pan Inhibitor 99.95%
TMP195
HDAC6, IC50: 47800 nM
       
HDAC4, IC50: 111 nM
HDAC5, IC50: 106 nM
HDAC7, IC50: 46 nM
HDAC8, IC50: 11700 nM
HDAC9, IC50: 9 nM
        Pan Inhibitor 99.42%
Abexinostat
HDAC6, Ki: 17 nM
 
HDAC1, Ki: 7 nM
HDAC2, Ki: 19 nM
HDAC3/SMRT, Ki: 8.2 nM
     
HDAC8, Ki: 280 nM
 
HDAC10, Ki: 24 nM
      Pan Inhibitor 98.61%
Pracinostat
HDAC6, IC50: 1008 nM
 
HDAC1, IC50: 49 nM
HDAC2, IC50: 96 nM
HDAC3, IC50: 43 nM
HDAC4, IC50: 56 nM
HDAC5, IC50: 47 nM
HDAC7, IC50: 137 nM
HDAC8, IC50: 140 nM
HDAC9, IC50: 70 nM
HDAC10, IC50: 40 nM
HDAC11, IC50: 93 nM
    Pan Inhibitor 99.07%
Givinostat hydrochloride monohydrate
hHDAC6, IC50: 315 nM
 
hHDAC1, IC50: 198 nM
hHDAC2, IC50: 325 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC7, IC50: 524 nM
hHDAC8, IC50: 854 nM
hHDAC9, IC50: 541 nM
hHDAC10, IC50: 340 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
Pan Inhibitor >98.0%
CUDC-101
HDAC6, IC50: 5.1 nM
HDAC, IC50: 4.4 nM
HDAC1, IC50: 4.5 nM
HDAC2, IC50: 12.6 nM
HDAC3, IC50: 9.1 nM
HDAC4, IC50: 13.2 nM
HDAC5, IC50: 11.4 nM
HDAC7, IC50: 373 nM
HDAC8, IC50: 79.8 nM
HDAC9, IC50: 67.2 nM
HDAC10, IC50: 26.1 nM
      Pan Inhibitor 99.59%
Santacruzamate A
HDAC6, IC50: 434 nM
   
HDAC2, IC50: 119 pM
                    Pan Inhibitor 99.72%
EDO-S101
HDAC6, IC50: 6 nM
 
HDAC1, IC50: 9 nM
HDAC2, IC50: 9 nM
HDAC3, IC50: 25 nM
     
HDAC8, IC50: 107 nM
 
HDAC10, IC50: 72 nM
      Pan Inhibitor 98.09%
SR-4370
HDAC6, IC50: 3400 nM
 
HDAC1, IC50: 130 nM
HDAC2, IC50: 580 nM
HDAC3, IC50: 6 nM
     
HDAC8, IC50: 2300 nM
          Pan Inhibitor 98.33%
Bufexamac
HDAC6, Kd app: 10.7 μM
     
HDAC3, Kd app: 341 μM
     
HDAC8, Kd app: 235 μM
 
HDAC10, Kd app: 12.3 μM
      Pan Inhibitor >98.0%
Droxinostat
HDAC6, IC50: 2.47 μM
     
HDAC3, IC50: 16.9 μM
     
HDAC8, IC50: 1.46 μM
          Pan Inhibitor 98.86%
Givinostat
hHDAC6, IC50: 315 nM
 
hHDAC1, IC50: 198 nM
hHDAC2, IC50: 325 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC7, IC50: 524 nM
hHDAC8, IC50: 854 nM
hHDAC9, IC50: 541 nM
hHDAC10, IC50: 340 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
Pan Inhibitor
JAK/HDAC-IN-1
HDAC6, IC50: 120 nM
HDAC, IC50: 2 nM
 
HDAC2, IC50: 14 nM
       
HDAC8, IC50: 2470 nM
          Pan Inhibitor 98.04%
Resminostat
HDAC6, IC50: 71.8 nM
 
HDAC1, IC50: 42.5 nM
 
HDAC3, IC50: 50.1 nM
     
HDAC8, IC50: 877 nM
          Pan Inhibitor
BRD73954
HDAC6, IC50: 0.036 μM
   
HDAC2, IC50: 9 μM
       
HDAC8, IC50: 0.12 μM
          Pan Inhibitor >98.0%
UF010
HDAC6, IC50: 9.1 μM
 
HDAC1, IC50: 0.5 μM
HDAC2, IC50: 0.1 μM
HDAC3, IC50: 0.06 μM
     
HDAC8, IC50: 1.5 μM
 
HDAC10, IC50: 15.3 μM
HDAC11, IC50: 44.5 μM
    Pan Inhibitor 99.36%
MPT0E028
HDAC6, IC50: 29.5 nM
 
HDAC1, IC50: 53.0 nM
HDAC2, IC50: 106.2 nM
       
HDAC8, IC50: 2532.6 nM
          Pan Inhibitor
AES-135
HDAC6, IC50: 190 nM
     
HDAC3, IC50: 654 nM
           
HDAC11, IC50: 636 nM
    Pan Inhibitor
CHDI-390576
hHDAC6, IC50: 6.2 μM
 
HDAC1, IC50: 39.7 μM
 
HDAC3, IC50: 25.8 μM
HDAC4, IC50: 54 nM
HDAC5, IC50: 60 nM
HDAC7, IC50: 31 nM
HDAC8, IC50: 9.1 μM
hHDAC9, IC50: 50 nM
        Pan Inhibitor
PI3K/HDAC-IN-1
HDAC6, IC50: 6.6 nM
 
HDAC1, IC50: 1.4 nM
HDAC2, IC50: 3.0 nM
       
HDAC8, IC50: 18 nM
          Pan Inhibitor
HDACs/mTOR Inhibitor 1
HDAC6, IC50: 1.8 nM
 
HDAC1, IC50: 0.19 nM
                      Pan Inhibitor 99.12%
TH34
HDAC6, IC50: 4.6 μM
             
HDAC8, IC50: 1.9 μM
 
HDAC10, IC50: 7.7 μM
      Pan Inhibitor 99.05%
Givinostat hydrochloride
hHDAC6, IC50: 315 nM
 
hHDAC1, IC50: 198 nM
hHDAC2, IC50: 325 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC7, IC50: 524 nM
hHDAC8, IC50: 854 nM
hHDAC9, IC50: 541 nM
hHDAC10, IC50: 340 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
Pan Inhibitor
CRA-026440
HDAC6, Ki: 15 nM
 
HDAC1, Ki: 4 nM
HDAC2, Ki: 14 nM
HDAC3, Ki: 11 nM
     
HDAC8, Ki: 7 nM
 
HDAC10, Ki: 20 nM
      Pan Inhibitor