875320-29-9
Chemical Structure
Quisinostat
Synonym(s): JNJ-26481585
- CAS No.: 875320-29-9
- Formula:C21H26N6O2
- Molecular Weight:394.47
IUPAC Name: N-hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide
InChIKey: PAWIYAYFNXQGAP-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C(N2CCC(CNCC3=CN(C)C4=C3C=CC=C4)CC2)N=C1)NO
Biological Activity: Quisinostat (JNJ-26481585) is a potent and orally active pan-HDAC inhibitor (HDACi), with IC50 values ranging from 0.11 nM to 0.64 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11. Quisinostat has a broad spectrum antitumoral activity[1]. Quisinostat can induce autophagy in neuroblastoma cells[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Quisinostat | 99.71% | Quisinostat (JNJ-26481585) is a potent and orally active pan-HDAC inhibitor (HDACi), with IC50 values ranging from 0.11 nM to 0.64 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11. Quisinostat has a broad spectrum antitumoral activity. Quisinostat can induce autophagy in neuroblastoma cells. | ||||||||||||||||||||
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Similarity Score 0.99
HY-15433BQuisinostat hydrochloride -
Similarity Score 0.98
HY-15433AQuisinostat dihydrochloride -
Similarity Score 0.65
HY-155840KH16 -
Similarity Score 0.63
HY-144298HDAC1-IN-4 -
Similarity Score 0.62
HY-144297HDAC1-IN-3 -
Similarity Score 0.57
HY-143241HDAC-IN-34 -
Similarity Score 0.56
HY-144779HDAC10-IN-1 -
Similarity Score 0.55
HY-10226JNJ-16241199 -
Similarity Score 0.54
HY-163503HDAC6-IN-38 -
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References
- [1]. Arts J, et al. JNJ-26481585, a novel "second-generation" oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity. Clin Cancer Res. 2009 Nov 15;15(22):6841-51. [Content Brief]
- [2]. Vamsi Krishna Kommalapati, et al. Inhibition of JNJ-26481585-mediated autophagy induces apoptosis via ROS activation and mitochondrial membrane potential disruption in neuroblastoma cells. Mol Cell Biochem. 2020 May;468(1-2):21-34. [Content Brief]
