2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC MDM-2/p53 Apoptosis
  4. HDAC-IN-34

HDAC-IN-34 (compound 27) is a potent HDAC inhibitor, with IC50 values of 0.022 and 0.45 μM for HDAC1 and HDAC6, respectively. HDAC-IN-34 can bind to DNA and cause DNA damage. HDAC-IN-34 causes cells apoptosis through p53 signaling pathway. HDAC-IN-34 exhibits significant anti-proliferation effect against HCT-116 cells, with an IC50 of 1.41 μM.

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HDAC-IN-34 Chemical Structure

HDAC-IN-34 Chemical Structure

CAS No. : 2857097-33-5

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HDAC-IN-34 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC-IN-34 (compound 27) is a potent HDAC inhibitor, with IC50 values of 0.022 and 0.45 μM for HDAC1 and HDAC6, respectively. HDAC-IN-34 can bind to DNA and cause DNA damage. HDAC-IN-34 causes cells apoptosis through p53 signaling pathway. HDAC-IN-34 exhibits significant anti-proliferation effect against HCT-116 cells, with an IC50 of 1.41 μM[1].

IC50 & Target

HDAC1

0.022 ± 0. μM (IC50)

HDAC6

0.45 ± 0.0 μM (IC50)

Molecular Weight

446.50

Formula

C24H26N6O3
CAS No.
SMILES

COC1=CC2=C(C3=C(N2CC4CCN(CC4)C5=NC=C(C=N5)C(NO)=O)C(C)=NC=C3)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC-IN-34 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-342857097-33-5HDACMDM-2/p53ApoptosisHistone deacetylasesHCT-116 cellsDNA damagelow toxicityCancerHarmineA549HT-29HepG2Inhibitorinhibitorinhibit

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