2857097-33-5
Chemical Structure
HDAC-IN-34
- CAS No.: 2857097-33-5
- Formula:C24H26N6O3
- Molecular Weight:446.50
IUPAC Name: N-hydroxy-2-(4-((7-methoxy-1-methyl-9H-pyrido[3,4-b]indol-9-yl)methyl)piperidin-1-yl)pyrimidine-5-carboxamide
InChIKey: PKOCJUBUNIOWOL-UHFFFAOYSA-N
SMILES: COC1=CC2=C(C3=C(N2CC4CCN(CC4)C5=NC=C(C=N5)C(NO)=O)C(C)=NC=C3)C=C1
Biological Activity: HDAC-IN-34 (compound 27) is a potent HDAC inhibitor, with IC50 values of 0.022 and 0.45 μM for HDAC1 and HDAC6, respectively. HDAC-IN-34 can bind to DNA and cause DNA damage. HDAC-IN-34 causes cells apoptosis through p53 signaling pathway. HDAC-IN-34 exhibits significant anti-proliferation effect against HCT-116 cells, with an IC50 of 1.41 μM[1].
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HDAC-IN-34 | HDAC-IN-34 (compound 27) is a potent HDAC inhibitor, with IC50 values of 0.022 and 0.45 μM for HDAC1 and HDAC6, respectively. HDAC-IN-34 can bind to DNA and cause DNA damage. HDAC-IN-34 causes cells apoptosis through p53 signaling pathway. HDAC-IN-34 exhibits significant anti-proliferation effect against HCT-116 cells, with an IC50 of 1.41 μM. | |||||||||||||||||||||
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