2. Cell Cycle/DNA Damage Epigenetics Autophagy
  3. HDAC Autophagy
  4. Quisinostat hydrochloride

Quisinostat hydrochloride  (Synonyms: JNJ26481585 hydrochloride)

Cat. No.: HY-15433B
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Quisinostat (JNJ-26481585) hydrochloride is a potent and orally active pan-HDAC inhibitor (HDACi), with IC50 values ranging from 0.11 nM to 0.64 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11. Quisinostat hydrochloride has a broad spectrum antitumoral activity. Quisinostat hydrochloride can induce autophagy in neuroblastoma cells.

For research use only. We do not sell to patients.

CAS No. : 1083078-98-1

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Top Publications Citing Use of Products

    Quisinostat hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Apr 14;11(1):1792.  [Abstract]

    Quisinostat (25–50 nM; 7 d) blocked proliferation without inducing substantial death of HCC1569 cells.

    Quisinostat hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Apr 14;11(1):1792.  [Abstract]

    Quisinostat (4 mg/kg; i.p.; 21 d) caused reduced fractions of proliferating Ki67+ cells and no increase in apoptotic TUNEL+ cells in NSG mice to generate orthotopic xenografts, confirming that Quisinostat treatment induced cytostasis, not cell death, in vivo.

    Quisinostat hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Apr 14;11(1):1792.  [Abstract]

    Quisinostat (4 mg/kg; i.p.; once daily) strongly inhibited tumor maintenance in the three PDX models of lung, pancreas and breast cancer.

    Quisinostat hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Apr 14;11(1):1792.  [Abstract]

    Quisinostat (100 nM; 24 h) decreased total and phosphorylated SMAD2 (p-SMAD2) in HCC1569 cells.

    Quisinostat hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Apr 14;11(1):1792.  [Abstract]

    Quisinostat (4 mg/kg; i.p.; 21 d) treatment increased the levels of E-cadherin of HCC1569-induced orthotopic xenografts in NSG mice, indicating a reversion to a more epithelial phenotype.

    View All HDAC Isoform Specific Products:

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    HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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    Description

    Quisinostat (JNJ-26481585) hydrochloride is a potent and orally active pan-HDAC inhibitor (HDACi), with IC50 values ranging from 0.11 nM to 0.64 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11. Quisinostat hydrochloride has a broad spectrum antitumoral activity. Quisinostat hydrochloride can induce autophagy in neuroblastoma cells[1][2].

    IC50 & Target[1]

    HDAC1

    0.11 nM (IC50)

    HDAC2

    0.33 nM (IC50)

    HDAC4

    0.64 nM (IC50)

    HDAC10

    0.46 nM (IC50)

    HDAC11

    0.37 nM (IC50)

    HDAC3

    4.86 nM (EC50)

    HDAC5

    3.69 nM (IC50)

    HDAC8

    4.26 nM (IC50)

    HDAC9

    32.1 nM (IC50)

    HDAC6

    76.8 nM (IC50)

    HDAC7

    119 nM (IC50)

    Molecular Weight

    430.93

    Formula

    C21H27ClN6O2
    CAS No.
    SMILES

    O=C(NO)C1=CN=C(N=C1)N2CCC(CC2)CNCC3=CN(C4=C3C=CC=C4)C.Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Quisinostat hydrochloride Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Quisinostat1083078-98-1JNJ26481585JNJ 26481585JNJ-26481585HDACAutophagyHistone deacetylasesInhibitorinhibitorinhibit

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