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Cat. No.: HY-155840

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KH16

Customer Review

Based on 1 Customer Validation

KH16 is a potent and low nanomolar HDAC inhibitor. KH16 is against class I HDACs HDAC1, HDAC2, and HDAC3, with IC₅₀ values ranging from 6 to 34 nM. KH16 induces cell apoptosis and is against tumor cells with various gene expression patterns.

For research use only. We do not sell to patients.

Purity: 98.62%

CAS No.: 3059680-59-7

Formula: C₁₈H₂₀N₆O₂

Molecular Weight:352.39

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Data Sheet (268 KB)

SDS

COA

KH16 Chemical Structure

CAS No.: 3059680-59-7

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Data Download

Data Sheet (268 KB)

SDS

COA

Handling Instructions (2659 KB)

To place orders, for customer services and technical support, please contact:

609-228-6898

[email protected] [email protected]

Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

You May Still Need

Library

Bioactive Compound Library Max

HY-L181

Library

Bioactive Compound Library

HY-L001

Library

Apoptosis Compound Library

HY-L003

Library

Cell Cycle/DNA Damage Compound Library

HY-L004

Library

Epigenetics Compound Library

HY-L005

Library

Histone Modification Research Compound Library

HY-L024

Library

Anti-Cancer Compound Library

HY-L025

Library

Anti-Aging Compound Library

HY-L034

Library

Reprogramming Compound Library

HY-L039

Library

Oxygen Sensing Compound Library

HY-L045

Library

Anti-Breast Cancer Compound Library

HY-L074

Library

Anti-Pancreatic Cancer Compound Library

HY-L077

Library

Anti-Blood Cancer Compound Library

HY-L079

Library

Anti-Liver Cancer Compound Library

HY-L101

Library

Osteogenesis Compound Library

HY-L131

Library

Cell Death Library

HY-L162

Library

Anti-Hematopathy Compound Library

HY-L171

Library

MCE Bioactive Compound Library

HY-L001V

Library

Anti-Brain Cancer Compound Library

HY-L188

Library

Protein Kinase Compound Library

HY-L196

Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

HY-L199

Library

High-Throughput Bioactive Compound Library

HY-L205

Library

High-Efficiency Gene Editing Compound Library

HY-L244

Library

Lactylation Compound Library

HY-L249

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

All HDAC Isoforms
More

HDAC

HDAC1

HDAC2

HDAC3

HDAC4

HDAC5

HDAC6

HDAC7

HDAC8

HDAC9

HDAC10

HDAC11

HD1

HD2

Biological Activity

Description

Chemical Information

Solvent & Solubility

In Vitro

Purity & Documentation

References

Help & FAQs

Classifications

Bioz

Biological Activity

Description

KH16 is a potent and low nanomolar HDAC inhibitor. KH16 is against class I HDACs HDAC1, HDAC2, and HDAC3, with IC₅₀ values ranging from 6 to 34 nM. KH16 induces cell apoptosis and is against tumor cells with various gene expression patterns^[1].

All HDAC Isoforms :

HDAC

HDAC1

HDAC2

HDAC3

HDAC4

HDAC5

HDAC6

HDAC7

HDAC8

HDAC9

HDAC10

HDAC11

HD1

HD2

Chemical Information

CAS No. 3059680-59-7

Appearance Solid

Molecular Weight 352.39

Formula C₁₈H₂₀N₆O₂

Color Off-white to light yellow

SMILES

O=C(C1=CN=C(N=C1)N2CCN(CC2)CC3=CNC4=C3C=CC=C4)NO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder -20°C 3 years

4°C 2 years

In solvent -80°C 6 months

-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (709.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8378 mL

14.1888 mL

28.3776 mL

5 mM

0.5676 mL

2.8378 mL

5.6755 mL

10 mM

0.2838 mL

1.4189 mL

2.8378 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(final) Volume _(final)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)

SDS (251 KB)

English - EN (251 KB)

Français - FR (251 KB)

Deutsch - DE (251 KB)

Norwegian - NO (251 KB)

Español - ES (251 KB)

Swedish - SV (251 KB)

Italian - IT (251 KB)

Korean - KR (251 KB)

Portuguese - PT (251 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

References

[1]. Ramy Ashry, et al. NOXA Accentuates Apoptosis Induction by a Novel Histone Deacetylase Inhibitor. Cancers (Basel). 2023 Jul 17;15(14):3650. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg

DMSO 1 mM 2.8378 mL 14.1888 mL 28.3776 mL 70.9441 mL

5 mM 0.5676 mL 2.8378 mL 5.6755 mL 14.1888 mL

10 mM 0.2838 mL 1.4189 mL 2.8378 mL 7.0944 mL

15 mM 0.1892 mL 0.9459 mL 1.8918 mL 4.7296 mL

20 mM 0.1419 mL 0.7094 mL 1.4189 mL 3.5472 mL

25 mM 0.1135 mL 0.5676 mL 1.1351 mL 2.8378 mL

30 mM 0.0946 mL 0.4730 mL 0.9459 mL 2.3648 mL

40 mM 0.0709 mL 0.3547 mL 0.7094 mL 1.7736 mL

50 mM 0.0568 mL 0.2838 mL 0.5676 mL 1.4189 mL

60 mM 0.0473 mL 0.2365 mL 0.4730 mL 1.1824 mL

80 mM 0.0355 mL 0.1774 mL 0.3547 mL 0.8868 mL

100 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.7094 mL

KH16 Related Classifications

HY-155840 Related Classifications

Cell Cycle/DNA Damage Apoptosis Epigenetics

HDAC Apoptosis

Disease Areas

Cancer Inflammation or Immune System Disease Blood or Cardio-cerebrovascular Disease Digestive System Disease

Breast Cancer Liver Cancer Digestive System Cancer Leukemia/Lymphoma/Myeloma Blood Disease Pancreatic Cancer Digestive System Inflammation

Cancer

Cancer Targeted Therapy Cancer Metabolism and Metastasis

Powered by Bioz See more details on Bioz

Keywords

KH16
3059680-59-7
KH 16
KH-16
HDAC
Apoptosis
apoptosis
colon cancer
HDACi
NOXA
pancreatic cancer
?colorectal cancer
Inhibitor
inhibitor
inhibit

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Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8378 mL	14.1888 mL	28.3776 mL	70.9441 mL
5 mM	0.5676 mL	2.8378 mL	5.6755 mL	14.1888 mL
10 mM	0.2838 mL	1.4189 mL	2.8378 mL	7.0944 mL
15 mM	0.1892 mL	0.9459 mL	1.8918 mL	4.7296 mL
20 mM	0.1419 mL	0.7094 mL	1.4189 mL	3.5472 mL
25 mM	0.1135 mL	0.5676 mL	1.1351 mL	2.8378 mL
30 mM	0.0946 mL	0.4730 mL	0.9459 mL	2.3648 mL
40 mM	0.0709 mL	0.3547 mL	0.7094 mL	1.7736 mL
50 mM	0.0568 mL	0.2838 mL	0.5676 mL	1.4189 mL
60 mM	0.0473 mL	0.2365 mL	0.4730 mL	1.1824 mL
80 mM	0.0355 mL	0.1774 mL	0.3547 mL	0.8868 mL
100 mM	0.0284 mL	0.1419 mL	0.2838 mL	0.7094 mL

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Biological Activity

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