HDAC6-IN-38
HDAC6-IN-38 (Compound Z-7) is an inhibitor for histone deacetylase 6 (HDAC6), with an IC50 of 3.25 nM. HDAC6-IN-38 inhibits proliferation of cells MGC 803.
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- CAS No.: 3030872-95-5
- Formule: C21H21N3O3
- Masse moléculaire:363.41
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
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Activité biologique
Description
IC50 & Target
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HDAC6 3.11 nM (IC50) |
HDAC1 20.5 nM (IC50) |
Chemical Information
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CAS No. 3030872-95-5
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Masse moléculaire 363.41
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Formule C21H21N3O3
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SMILES
O=C(C1=CC=C(CNC(C2=CN(CC3CC3)C4=C2C=CC=C4)=O)C=C1)NO
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC6-IN-38 Related Classifications
HY-163503 Related Classifications
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