1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. Nexturastat A

Nexturastat A 

Cat. No.: HY-16699 Purity: 99.03%
COA Handling Instructions

Nexturastat A is a potent, selective HDAC6 inhibitor. Nexturastat A has inhibitory for HDAC6 with an IC50 of 5 nM. Nexturastat A can be used for the research of multiple myeloma (MM).

For research use only. We do not sell to patients.

Nexturastat A Chemical Structure

Nexturastat A Chemical Structure

CAS No. : 1403783-31-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 89 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 89 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 79 In-stock
Estimated Time of Arrival: December 31
5 mg USD 119 In-stock
Estimated Time of Arrival: December 31
10 mg USD 145 In-stock
Estimated Time of Arrival: December 31
50 mg USD 385 In-stock
Estimated Time of Arrival: December 31
100 mg USD 605 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nexturastat A is a potent, selective HDAC6 inhibitor. Nexturastat A has inhibitory for HDAC6 with an IC50 of 5 nM. Nexturastat A can be used for the research of multiple myeloma (MM)[1][2].

IC50 & Target[1]

HDAC6

5.02 nM (IC50)

HDAC8

0.954 μM (IC50)

HDAC1

3.02 μM (IC50)

HDAC7

4.46 μM (IC50)

HDAC11

5.14 μM (IC50)

HDAC3

6.68 μM (IC50)

HDAC9

6.72 μM (IC50)

HDAC2

6.92 μM (IC50)

HDAC10

7.57 μM (IC50)

HDAC4

9.39 μM (IC50)

HDAC5

11.7 μM (IC50)

In Vitro

Nexturastat A (5 g) has inhibitory for HDAC6 with IC50 values of 0.005 μM[1].
Nexturastat A (0-10 μM; 24 h) has substrate selectivity for HDAC62[1].
Nexturastat A has antiproliferative activity against B16 murine melanoma cells with IC50 values of 14.3 μM[1].
Nexturastat A (NexA) (0-40 µM; 48 h) suppresses viability and induced G1 phase arrest of human MM cells[2].
Nexturastat A (0, 30, 40 μM; 48 h) promotes apoptosis of MM cells via transcriptional activation of the p21 promoter[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: B16 murine melanoma cells
Concentration: 0-10 μM
Incubation Time: 24 h
Result: Increased the level of acetyl α-tubulin levels in a dose-dependent.

Cell Viability Assay[2]

Cell Line: RPMI-8226 and U266 cells
Concentration: 0-40 µM
Incubation Time: 48 h
Result: Impaired multiple myeloma (MM) cells viability in a dose- and time-dependent manner.

Apoptosis Analysis[2]

Cell Line: RPMI-8226 and U266 cells
Concentration: 0, 30, 40 μM
Incubation Time: 48 h
Result: Induced cell apoptosis in human MM cells.

RT-PCR[2]

Cell Line: RPMI-8226 and U266 cells
Concentration: 30 µM
Incubation Time: 48 h
Result: Increased the levels of p21 mRNA in RPMI-8226 and U266 cells.
In Vivo

Nexturastat A (NexA) (every two days, 20 days) inhibits tumor growth in murine xenograft models of MM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

341.40

Formula

C19H23N3O3

CAS No.
SMILES

O=C(NO)C1=CC=C(CN(CCCC)C(NC2=CC=CC=C2)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 56 mg/mL (164.03 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9291 mL 14.6456 mL 29.2912 mL
5 mM 0.5858 mL 2.9291 mL 5.8582 mL
10 mM 0.2929 mL 1.4646 mL 2.9291 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.32 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.32 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.32 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Nexturastat A
Cat. No.:
HY-16699
Quantity:
MCE Japan Authorized Agent: