1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. Nexturastat A

Nexturastat A 

Cat. No.: HY-16699 Purity: 98.49%
Handling Instructions

Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM; no inhibition on other HDAC forms.

For research use only. We do not sell to patients.

Nexturastat A Chemical Structure

Nexturastat A Chemical Structure

CAS No. : 1403783-31-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 81 In-stock
Estimated Time of Arrival: December 31
1 mg USD 72 In-stock
Estimated Time of Arrival: December 31
5 mg USD 108 In-stock
Estimated Time of Arrival: December 31
10 mg USD 132 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 550 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM; no inhibition on other HDAC forms. IC50 value: 5 nM [1] Target: HDAC6 inhibitor Nexturastat A displayed low micromolar activity compared to the low nanomolar activity against HDAC6. Moreover, it also demonstrated high levels of selective inhibition against members of the related Class 2 HDAC isozymes reaching >1000-fold selective in some cases. Compared to the pan-selective HDACI LBH589, Nexturastat A is approximately 100-fold less potent in inducing murine B16 melanoma cell death.

IC50 & Target[1]

HDAC6

5.02 nM (IC50)

HDAC8

0.954 μM (IC50)

HDAC1

3.02 μM (IC50)

HDAC7

4.46 μM (IC50)

HDAC11

5.14 μM (IC50)

HDAC3

6.68 μM (IC50)

HDAC9

6.72 μM (IC50)

HDAC2

6.92 μM (IC50)

HDAC10

7.57 μM (IC50)

HDAC4

9.39 μM (IC50)

HDAC5

11.7 μM (IC50)

Molecular Weight

341.40

Formula

C₁₉H₂₃N₃O₃

CAS No.

1403783-31-2

SMILES

O=C(NO)C1=CC=C(CN(CCCC)C(NC2=CC=CC=C2)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 56 mg/mL (164.03 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9291 mL 14.6456 mL 29.2912 mL
5 mM 0.5858 mL 2.9291 mL 5.8582 mL
10 mM 0.2929 mL 1.4646 mL 2.9291 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Nexturastat A
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HY-16699
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