1616493-44-7
1616493-44-7
Chemical Structure
Tucidinostat
Synonym(s): Chidamide; HBI-8000; CS 055
- CAS No.: 1616493-44-7
- Formula:C22H19FN4O2
- Molecular Weight:390.41
IUPAC Name: (E)-N-(2-amino-4-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide
InChIKey: SZMJVTADHFNAIS-BJMVGYQFSA-N
SMILES: O=C(C1=CC=C(CNC(/C=C/C2=CN=CC=C2)=O)C=C1)NC(C=CC(F)=C3)=C3N
Biological Activity: Tucidinostat (Chidamide) is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC50s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tucidinostat | 98.74% | Tucidinostat (Chidamide) is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC50s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9. | ||||||||||||||||||||
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Tucidinostat (Standard) | ≥98% | Tucidinostat (Standard) is the analytical standard of Tucidinostat. This product is intended for research and analytical applications. Tucidinostat (Chidamide) is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC50s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9. | ||||||||||||||||||||
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Tucidinostat-d4 | 98.63% | Tucidinostat-d4 is the deuterium labeled Tucidinostat. Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, respectively. | ||||||||||||||||||||
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References
