2. Cell Cycle/DNA Damage Epigenetics Anti-infection
  3. HDAC Parasite
  4. Apicidin

Apicidin (OSI 2040) is a fungal metabolite, acts as an orally active histone deacetylase 7/8 (HDAC7/8) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity. Apicidin can be used for cancer research.

For research use only. We do not sell to patients.

CAS No. : 183506-66-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Based on 5 publication(s) in Google Scholar

Apicidin Related Antibodies

Top Publications Citing Use of Products

    Apicidin purchased from MedChemExpress. Usage Cited in: Cancer Biol Ther. 2023 Dec 31;24(1):2228497.  [Abstract]

    THP-1 cells were treated with Apidin for 48–72 hours. Cell proliferation was then assessed using the CCK-8 assay.

    Apicidin purchased from MedChemExpress. Usage Cited in: Cancer Biol Ther. 2023 Dec 31;24(1):2228497.  [Abstract]

    THP-1 cells were treated with Apidin for 48–72 hours. Apoptosis was analyzed by Annexin V and 7-AAD double staining combined with flow cytometry.

    Apicidin purchased from MedChemExpress. Usage Cited in: Cancer Biol Ther. 2023 Dec 31;24(1):2228497.  [Abstract]

    The expression of QPCT protein in THP-1, NB4, and HL-60 cells treated with Apidin (1 μM) or DMSO for 48 hours was detected by Western blot.

    Apicidin purchased from MedChemExpress. Usage Cited in: Cancer Biol Ther. 2023 Dec 31;24(1):2228497.  [Abstract]

    Qrt-PCR analysis was performed on the expression of QPCT in AML monocytes (MNCs) treated with Apidin (1 μM).

    Apicidin purchased from MedChemExpress. Usage Cited in: Cancer Biol Ther. 2023 Dec 31;24(1):2228497.  [Abstract]

    Apicidin (1 μM) was used to detect the sonication efficiency of genomic DNA by agarose gel electrophoresis.

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    Description

    Apicidin (OSI 2040) is a fungal metabolite, acts as an orally active histone deacetylase 7/8 (HDAC7/8) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity. Apicidin can be used for cancer research[1][2][3][4].

    IC50 & Target

    HDAC7

     

    HDAC8

     

    In Vitro

    Apicidin inhibits mammalian (HeLa) cell proliferation in vitro (50% inhibitory concentrations, 50-100 nM)[2].
    Apicidin (0.1-10 μM, 24 h) inhibits the growth and the expression of HDAC in AT-84 cells dose-dependently[4].
    Apicidin (1, 5 μM, 24 h) induces apoptosis and autophagy in AT-84 cells dose-dependently[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Apicidin Related Antibodies
    In Vivo

    Apicidin (5 mg/kg, i.p., daily for 14 d) inhibits tumor growth up to 47% relative to the control group and exerts no significant systemic toxicity, including body weight changes or other apparent adverse effects[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: BALB/C mice[2].
    Dosage: 2-20 mg/kg (i.p.); 25/50 mg/kg (oral).
    Administration: I.P. and Oral.
    Result: Demonstrated parenteral and oral efficacy against an acute strain of P. berghei in mice.
    Molecular Weight

    623.78

    Formula

    C34H49N5O6
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(NC(C(N1[C@]2([H])CCCC1)=O)[C@@H](C)CC)[C@@H](NC([C@@H](NC2=O)CCCCCC(CC)=O)=O)CC3=CN(OC)C4=C3C=CC=C4
    Structure Classification
    Initial Source

    Toxic Fusarium
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 25 mg/mL (40.08 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6031 mL 8.0156 mL 16.0313 mL
    5 mM 0.3206 mL 1.6031 mL 3.2063 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.87%

    SDS (480 KB)

    COA (250 KB) LCMS (253 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.6031 mL 8.0156 mL 16.0313 mL 40.0782 mL
    5 mM 0.3206 mL 1.6031 mL 3.2063 mL 8.0156 mL
    10 mM 0.1603 mL 0.8016 mL 1.6031 mL 4.0078 mL
    15 mM 0.1069 mL 0.5344 mL 1.0688 mL 2.6719 mL
    20 mM 0.0802 mL 0.4008 mL 0.8016 mL 2.0039 mL
    25 mM 0.0641 mL 0.3206 mL 0.6413 mL 1.6031 mL
    30 mM 0.0534 mL 0.2672 mL 0.5344 mL 1.3359 mL
    40 mM 0.0401 mL 0.2004 mL 0.4008 mL 1.0020 mL
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    Apicidin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Apicidin183506-66-3OSI 2040OSI2040OSI-2040HDACParasiteHistone deacetylasesfungal metaboliteHDAC7HDAC8antiparasiticantiproliferativecancerAT-84Inhibitorinhibitorinhibit

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