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Cat. No.: HY-110061

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(2R,4R,6S)-Tubacin

Name: (2R,4R,6S)-Tubacin
Brand: MedChemExpress
SKU: HY-110061
Price: 496.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(2R,4R,6S)-Tubacin is the 2R,4R,6S enantiomer of Tubacin (HY-13428). Tubacin is a potent and selective inhibitor of HDAC6, with an IC₅₀ value of 4 nM and approximately 350-fold selectivity over HDAC1. Tubacin also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2).

For research use only. We do not sell to patients.

CAS No.: 1350555-93-9
Formula: C₄₁H₄₃N₃O₇S
Molecular Weight:721.86

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

(2R,4R,6S)-Tubacin Chemical Structure

CAS No.: 1350555-93-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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Chemical Information
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Biological Activity

Description

All HDAC Isoforms :

All Beta-lactamase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	EC₅₀	2.5 μM Compound: 38	Inhibition of HDAC-6 in human A549 cells assessed as induction of alpha-tubulin acetylation after 20 hrs by cytoblot analysis Inhibition of HDAC-6 in human A549 cells assessed as induction of alpha-tubulin acetylation after 20 hrs by cytoblot analysis	10.1039/C1MD00199J
A549	EC₅₀	2.9 μM Compound: Tubacin	Inhibition of HDAC6 in human A549 cells assessed as induction of alpha-tubulin acetylation by fluorescence microscopy Inhibition of HDAC6 in human A549 cells assessed as induction of alpha-tubulin acetylation by fluorescence microscopy	[PMID: 16408003]
HeLa	IC₅₀	2.9 μM Compound: Tubacin	Inhibition of HDAC6 in human HeLa cells using acetyl tubulin as substrate assessed as Ac-Lys accumulation in nuclear histones after 6 hrs by immunofluorescence assay Inhibition of HDAC6 in human HeLa cells using acetyl tubulin as substrate assessed as Ac-Lys accumulation in nuclear histones after 6 hrs by immunofluorescence assay	[PMID: 23964961]
HeLa	IC₅₀	2.9 μM Compound: Tubacin	Inhibition of HDAC6 in human HeLa cells assessed as reduction in K40 hyperacetylation of alpha-tubulin incubated for 6 hrs by immunofluorescence assay Inhibition of HDAC6 in human HeLa cells assessed as reduction in K40 hyperacetylation of alpha-tubulin incubated for 6 hrs by immunofluorescence assay	[PMID: 25454270]
T-24	EC₅₀	2.9 μM Compound: Tubacin	Induction of histone H3 acetylation in human T24 cells Induction of histone H3 acetylation in human T24 cells	[PMID: 19111466]

Chemical Information

CAS No. 1350555-93-9
Molecular Weight 721.86
Formula C₄₁H₄₃N₃O₇S
SMILES

OCC(C=C1)=CC=C1[C@H](C2)O[C@@H](C3=CC=C(C=C3)NC(CCCCCCC(NO)=O)=O)O[C@H]2CSC4=NC(C5=CC=CC=C5)=C(C6=CC=CC=C6)O4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lu CY, et al. Tubacin, an HDAC6 Selective Inhibitor, Reduces the Replication of the Japanese Encephalitis Virus via the Decrease of Viral RNA Synthesis. Int J Mol Sci. 2017 May 1;18(5):954. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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(2R,4R,6S)-Tubacin

All HDAC Isoforms

All Beta-lactamase Isoforms