1350555-93-9
1350555-93-9
Chemical Structure
(2R,4R,6S)-Tubacin
- No. CAS: 1350555-93-9
- Formula:C41H43N3O7S
- Molecular Weight:721.86
InChIKey: BHUZLJOUHMBZQY-YXQOSMAKSA-N
SMILES: OCC(C=C1)=CC=C1[C@H](C2)O[C@@H](C3=CC=C(C=C3)NC(CCCCCCC(NO)=O)=O)O[C@H]2CSC4=NC(C5=CC=CC=C5)=C(C6=CC=CC=C6)O4
Biological Activity: (2R,4R,6S)-Tubacin is the 2R,4R,6S enantiomer of Tubacin (HY-13428). Tubacin is a potent and selective inhibitor of HDAC6, with an IC50 value of 4 nM and approximately 350-fold selectivity over HDAC1. Tubacin also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2)[1].
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(2R,4R,6S)-Tubacin | (2R,4R,6S)-Tubacin is the 2R,4R,6S enantiomer of Tubacin (HY-13428). Tubacin is a potent and selective inhibitor of HDAC6, with an IC50 value of 4 nM and approximately 350-fold selectivity over HDAC1. Tubacin also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2). | |||||||||||||||||||||
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References
Keywords
