2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. SW-100

SW-100 

Cat. No.: HY-115475 Purity: 99.59%
COA Handling Instructions

SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier.

For research use only. We do not sell to patients.

SW-100 Chemical Structure

SW-100 Chemical Structure

CAS No. : 2126744-35-0

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Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 165 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 165 In-stock
Solid
5 mg USD 150 In-stock
10 mg USD 250 In-stock
50 mg USD 950 In-stock
100 mg USD 1500 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

SW-100 Related Antibodies

Top Publications Citing Use of Products

View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier[1].

IC50 & Target[1]

HDAC1

5.23 μM (IC50)

HDAC2

32.8 μM (IC50)

HDAC3

29.5 μM (IC50)

HDAC4

10.9 μM (IC50)

HDAC5

4.07 μM (IC50)

HDAC6

2.3 nM (IC50)

HDAC7

4.55 μM (IC50)

HDAC8

3.72 μM (IC50)

HDAC9

3.46 μM (IC50)

HDAC10

26.2 μM (IC50)

HDAC11

5.72 μM (IC50)

In Vitro

SW-100 (0.01-10 µM; 48 hours) shows obvious increase in the acetylated α-tubulin levels in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SW-100 Related Antibodies

Western Blot Analysis[1]

Cell Line: HEK293 cells
Concentration: 0.01, 0.1, 1, 10 µM
Incubation Time: 48 hours
Result: Showed obvious increase in the acetylated α-tubulin levels in a dose-dependent manner.
In Vivo

SW-100 (20 mg/kg; i.p.; twice a day for two days) ameliorates several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in mouse model of Fragile X syndrome[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-10 weeks old C57BL/6 mice (Fmr1-/- mice)[1]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection; twice a day for two days
Result: Ameliorated several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in Fmr1-/- mice。
Molecular Weight

316.78

Appearance

Solid

Formula

C17H17ClN2O2
CAS No.
SMILES

O=C(NO)C1=CC=C(CN2CCCC3=C2C=CC(Cl)=C3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (394.60 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1568 mL 15.7838 mL 31.5676 mL
5 mM 0.6314 mL 3.1568 mL 6.3135 mL
10 mM 0.3157 mL 1.5784 mL 3.1568 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.57 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.57 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.57 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.59%

COA (246 KB) LCMS (269 KB)

Handling Instructions (2659 KB)
References
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SW-100 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SW-1002126744-35-0SW100SW 100HDACHistone deacetylasesInhibitorinhibitorinhibit

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