1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. SW-100

SW-100 

Cat. No.: HY-115475 Purity: 99.92%
Handling Instructions

SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier.

For research use only. We do not sell to patients.

SW-100 Chemical Structure

SW-100 Chemical Structure

CAS No. : 2126744-35-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 850 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier[1].

IC50 & Target[1]

HDAC1

5.23 μM (IC50)

HDAC2

32.8 μM (IC50)

HDAC3

29.5 μM (IC50)

HDAC4

10.9 μM (IC50)

HDAC5

4.07 μM (IC50)

HDAC6

2.3 nM (IC50)

HDAC7

4.55 μM (IC50)

HDAC8

3.72 μM (IC50)

HDAC9

3.46 μM (IC50)

HDAC10

26.2 μM (IC50)

HDAC11

5.72 μM (IC50)

In Vitro

SW-100 increases the levels of acetylated α-tubulin in a dose-dependent manner in HEK293 cells[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (394.60 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1568 mL 15.7838 mL 31.5676 mL
5 mM 0.6314 mL 3.1568 mL 6.3135 mL
10 mM 0.3157 mL 1.5784 mL 3.1568 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.57 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.57 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.57 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

316.78

Formula

C₁₇H₁₇ClN₂O₂

CAS No.

2126744-35-0

SMILES

O=C(NO)C1=CC=C(CN2CCCC3=C2C=CC(Cl)=C3)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
SW-100
Cat. No.:
HY-115475
Quantity:

SW-100

Cat. No.: HY-115475