1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. Bufexamac

Bufexamac (Synonyms: Bufexamic acid)

Cat. No.: HY-B0494 Purity: >98.0%
Handling Instructions

Bufexamac is a class IIB histone deacetylases (HDAC6 and HDAC10) inhibitor used as an anti-inflammatory agent.

For research use only. We do not sell to patients.

Bufexamac Chemical Structure

Bufexamac Chemical Structure

CAS No. : 2438-72-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 108 In-stock
Estimated Time of Arrival: December 31
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Description

Bufexamac is a class IIB histone deacetylases (HDAC6 and HDAC10) inhibitor used as an anti-inflammatory agent.

IC50 & Target[1]

HDAC6

10.7 μM (Kd app)

HDAC10

12.3 μM (Kd app)

HDAC8

235 μM (Kd app)

HDAC3

341 μM (Kd app)

Molecular Weight

223.27

Formula

C₁₂H₁₇NO₃

CAS No.

2438-72-4

SMILES

O=C(NO)CC1=CC=C(OCCCC)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (447.89 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4789 mL 22.3944 mL 44.7888 mL
5 mM 0.8958 mL 4.4789 mL 8.9578 mL
10 mM 0.4479 mL 2.2394 mL 4.4789 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (11.20 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.20 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.20 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Bufexamac
Cat. No.:
HY-B0494
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