2438-72-4
2438-72-4
Chemical Structure
Bufexamac
Synonym(s): Bufexamic acid
- CAS No.: 2438-72-4
- Formula:C12H17NO3
- Molecular Weight:223.27
IUPAC Name: 2-(4-butoxyphenyl)-N-hydroxyacetamide
InChIKey: MXJWRABVEGLYDG-UHFFFAOYSA-N
SMILES: O=C(NO)CC1=CC=C(OCCCC)C=C1
Biological Activity: Bufexamac is a selective Ⅱb HDAC (HDAC6, HDAC10) and LTA4H dual inhibitor, with Kds of 0.53 µM and 0.22 µM for HDAC6 and HDAC10. Bufexamac is a nonsteroida anti-inflammatory drug[1][2][3].
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Bufexamac | 98.47% | Bufexamac is a selective Ⅱb HDAC (HDAC6, HDAC10) and LTA4H dual inhibitor, with Kds of 0.53 µM and 0.22 µM for HDAC6 and HDAC10. Bufexamac is a nonsteroida anti-inflammatory drug. | ||||||||||||||||||||
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Bufexamac (Standard) | ≥98% | Bufexamac (Standard) is the analytical standard of Bufexamac. This product is intended for research and analytical applications. Bufexamac is a selective Ⅱb HDAC (HDAC6, HDAC10) and LTA4H dual inhibitor, with Kds of 0.53 μM and 0.22 μM for HDAC6 and HDAC10. Bufexamac is a nonsteroida anti-inflammatory drug. | ||||||||||||||||||||
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References
- [1]. Bantscheff M, et al. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol. 2011 Mar;29(3):255-65. [Content Brief]
- [2]. Oehme I, et al. Histone deacetylase 10 promotes autophagy-mediated cell survival. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):E2592-601. [Content Brief]
- [3]. Xiao Q, et al. Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H. Sci Rep. 2016 Apr 29;6:25298. [Content Brief]
