Atenolol hydrochloride
Atenolol hydrochloride is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol hydrochloride can be used for the research of hypertension and angina pectoris.
For research use only. We do not sell to patients.
- CAS No.: 51706-40-2
- Formula: C14H23ClN2O3
- Molecular Weight:302.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Adrenergic Receptor Isoforms
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Biological Activity
Chemical Information
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CAS No. 51706-40-2
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Molecular Weight 302.80
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Formula C14H23ClN2O3
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SMILES
O=C(N)CC1=CC=C(OCC(O)CNC(C)C)C=C1.Cl
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Synonyms
(RS)-Atenolol hydrochloride; Tenormin hydrochloride; ICI 66082 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Heel RC, et al. Atenolol: a review of its pharmacological properties and therapeutic efficacy in angina pectoris and hypertension. Drugs. 1979;17(6):425-460. [Content Brief]
[2]. Engel G, et al. (+/-)[125Iodo] cyanopindolol, a new ligand for beta-adrenoceptors: identification and quantitation of subclasses of beta-adrenoceptors in guinea pig. Naunyn Schmiedebergs Arch Pharmacol. 1981;317(4):277-285. [Content Brief]
[3]. Corsini A, et al. Effect of the nifedipine-atenolol association on arterial myocyte migration and proliferation. Pharmacol Res. 1993 May-Jun;27(4):299-307. [Content Brief]
[4]. Lorusso B, et al. Β-blockers activate autophagy on infantile hemangioma-derived endothelial cells in vitro. Vascul Pharmacol. 2022 Oct;146:107110 [Content Brief]
[5]. Shen FM, et al. Synergistic effects of atenolol and amlodipine for lowering and stabilizing blood pressure in 2K1C renovascular hypertensive rats. Acta Pharmacol Sin. 2005 Nov;26(11):1303-8. [Content Brief]
[6]. Gould S, et al. Effect of pretreatment with atenolol and nifedipine on ZD6126-induced cardiac toxicity in rats. J Natl Cancer Inst. 2007 Nov 21;99(22):1724-8. [Content Brief]
[7]. Horinouchi T, et al. Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol. Life Sci. 2007 Jul 12;81(5):399-404. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)