1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Atenolol

Atenolol (Synonyms: (RS)-Atenolol)

Cat. No.: HY-17498 Purity: 99.61%
Handling Instructions

Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris.

For research use only. We do not sell to patients.

Atenolol Chemical Structure

Atenolol Chemical Structure

CAS No. : 29122-68-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 64 In-stock
Estimated Time of Arrival: December 31
5 g USD 161 In-stock
Estimated Time of Arrival: December 31
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50 g   Get quote  

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Based on 4 publication(s) in Google Scholar

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Description

Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris[1][2].

IC50 & Target[1]

Beta-1 adrenergic receptor

697 nM (Ki)

Clinical Trial
Molecular Weight

266.34

Formula

C₁₄H₂₂N₂O₃

CAS No.

29122-68-7

SMILES

O=C(N)CC1=CC=C(OCC(O)CNC(C)C)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (375.46 mM; Need ultrasonic)

H2O : 8.33 mg/mL (31.28 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7546 mL 18.7730 mL 37.5460 mL
5 mM 0.7509 mL 3.7546 mL 7.5092 mL
10 mM 0.3755 mL 1.8773 mL 3.7546 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution

  • 4.

    Add each solvent one by one:  PBS

    Solubility: 36.67 mg/mL (137.68 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

Atenolol(RS)-AtenololAdrenergic ReceptorBeta Receptorcardioselectiveliverdiseasehypertensionangina pectorisInhibitorinhibitorinhibit

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Atenolol
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HY-17498
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