Cat. No.: HY-B0284

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Nifedipine

(Synonyms: BAY-a-1040)

28 Cited Publications

Customer Review

Based on 28 publication(s) in Google Scholar

Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.

For research use only. We do not sell to patients.

Purity: 98.91%
CAS No.: 21829-25-4
Formula: C₁₇H₁₈N₂O₆
Molecular Weight:346.33

Storage:

4°C, protect from light

* In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

Nifedipine Chemical Structure

CAS No.: 21829-25-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (28)
Solvent & Solubility
- In Vitro
- In Vivo
Protocol
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.

All Calcium Channel Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>100 μM Compound: NIF	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
C6-BU-1	IC₅₀	1000 nM Compound: 1	IKCa channel inhibition was determined measuring ionomycin-induced Rb+ efflux of pre loaded rat C6BU1 glioma cell in comparison with Nifedipine IKCa channel inhibition was determined measuring ionomycin-induced Rb+ efflux of pre loaded rat C6BU1 glioma cell in comparison with Nifedipine	[PMID: 12873483]
Calvarial osteoblast	EC₅₀	1.54 μM Compound: nifedipine	Induction of mineralization in mouse calvarial osteoblasts assessed as increase of mineralized nodules formation after 21 days by alizarin red-S staining based spectrophotometric analysis Induction of mineralization in mouse calvarial osteoblasts assessed as increase of mineralized nodules formation after 21 days by alizarin red-S staining based spectrophotometric analysis	[PMID: 23214410]
CHO	EC₅₀	0.4 μM Compound: 53	Agonist activity at mouse TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium influx Agonist activity at mouse TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium influx	[PMID: 20356305]
CHO	IC₅₀	0.05 μM Compound: Nifedipine	Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in Chinese hamster ovary cells heterologically expressing alpha-1C subunit Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in Chinese hamster ovary cells heterologically expressing alpha-1C subunit	[PMID: 22761000]
CHO	IC₅₀	0.01 μM Compound: nifedipine	Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits	[PMID: 23812503]
HCT-116	IC₅₀	>100 μM Compound: NIF	Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
HEK293	IC₅₀	3.6 nM Compound: nifedipine	Displacement of (+)-[5-methyl-3H]PN200-100 from L type calcium channel Cav1.2b in rabbit expressed in HEK293 cells Displacement of (+)-[5-methyl-3H]PN200-100 from L type calcium channel Cav1.2b in rabbit expressed in HEK293 cells	[PMID: 18303827]
HEK293	IC₅₀	45 nM Compound: nifedipine	Displacement of (+)-[5-methyl-3H]PN200-100 from L type calcium channel Cav1.2a in rabbit expressed in HEK293 cells Displacement of (+)-[5-methyl-3H]PN200-100 from L type calcium channel Cav1.2a in rabbit expressed in HEK293 cells	[PMID: 18303827]
HEK293	IC₅₀	0.06 μM Compound: 1	Inhibition of L-type calcium channel expressed in HEK293 cells Inhibition of L-type calcium channel expressed in HEK293 cells	[PMID: 19004630]
HEK293	IC₅₀	0.086 μM Compound: Nif	Displacement of [3H]-PN200-110 from voltage-gated calcium channel subunit alpha Cav1.2a (unknown origin) expressed in HEK293 cells after 90 mins by liquid scintillation counting analysis Displacement of [3H]-PN200-110 from voltage-gated calcium channel subunit alpha Cav1.2a (unknown origin) expressed in HEK293 cells after 90 mins by liquid scintillation counting analysis	[PMID: 23586669]
HEK-293T	IC₅₀	1.5 μM Compound: Nifedipine	Inhibition of mouse Ido2 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation after 45 mins by spectrophotometric analysis Inhibition of mouse Ido2 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation after 45 mins by spectrophotometric analysis	[PMID: 23122865]
HEK-293T	IC₅₀	46 μM Compound: Nifedipine	Inhibition of mouse Ido1 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation after 45 mins by spectrophotometric analysis Inhibition of mouse Ido1 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation after 45 mins by spectrophotometric analysis	[PMID: 23122865]
HepG2	IC₅₀	9.4 μM Compound: Nifedipine	Cytotoxicity against human HepG2 cells after 24 hrs by LDH release assay Cytotoxicity against human HepG2 cells after 24 hrs by LDH release assay	[PMID: 30554954]
L929	IC₅₀	6.1 μM Compound: 1	Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique	[PMID: 19004630]
LLC-MK2	IC₅₀	101.75 μM Compound: Nifedipine	Antitrypanosomal activity against trypomastigotes of Trypanosoma cruzi infected in rhesus monkey LLC-MK2 cells after 48 hrs by MTT assay Antitrypanosomal activity against trypomastigotes of Trypanosoma cruzi infected in rhesus monkey LLC-MK2 cells after 48 hrs by MTT assay	[PMID: 20934347]
LLC-MK2	IC₅₀	588.73 μM Compound: Nifedipine	Cytotoxicity against rhesus monkey LLC-MK2 cells after 48 hrs by MTT assay Cytotoxicity against rhesus monkey LLC-MK2 cells after 48 hrs by MTT assay	[PMID: 20934347]
LLC-PK1	IC₅₀	472 μM Compound: Nifedipine	TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 0.1 uM) in MDR1-expressing LLC-PK1 cells TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 0.1 uM) in MDR1-expressing LLC-PK1 cells	[PMID: 12128170]
MCF7	IC₅₀	>100 μM Compound: NIF	Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
MM1.S	IC₅₀	57.9 μM Compound: NIF	Antiproliferative activity against human MM1S cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MM1S cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
NIH-3T3-G185	IC₅₀	113 μM Compound: Nifedipine	TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells	[PMID: 11743742]
Sf21	IC₅₀	30.7 μM Compound: Nifedipine	Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]
Sf21	IC₅₀	45.4 μM Compound: Nifedipine	Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]
SH-SY5Y	IC₅₀	1.35 μM Compound: nifedipine	Inhibition of human Cav1.3 channel in human SH-SY5Y cells assessed as 70 mM K+ induced calcium elevation compound treated 15 mins before stimulus by Fluo-4/AM assay Inhibition of human Cav1.3 channel in human SH-SY5Y cells assessed as 70 mM K+ induced calcium elevation compound treated 15 mins before stimulus by Fluo-4/AM assay	[PMID: 24754640]
SH-SY5Y	IC₅₀	22 μM Compound: Nifedipine	Inhibition of voltage-dependent L-type calcium channel in 70 mM K+-induced human SH-SY5Y cells assessed as blocking of depolarization-induced Ca2+ uptake by Fluo-4/AM dye based fluorescence microplate reader assay Inhibition of voltage-dependent L-type calcium channel in 70 mM K+-induced human SH-SY5Y cells assessed as blocking of depolarization-induced Ca2+ uptake by Fluo-4/AM dye based fluorescence microplate reader assay	[PMID: 31724859]

In Vitro

Nifedipine (BAY-a-1040) (100 μM) significantly lowers the viability of the WKPT-0293 Cl.2 Cells, and treatment of nifedipine (10 or 100 μM) plus FAC induces a significant reduction in cell viability, but there are no significant differences in viability between the control cells and the cells treated with 100 μM of FAC or 1 and 10 μM of nifedipine.Nifedipine (BAY-a-1040) (1, 10, or 100 μM) significantly increases iron level in WKPT-0293 Cl.2 cells. Nifedipine treatment also increases expression of TfR1, DMT1+IRE and DMT1-IRE in WKPT-0293 Cl.2 cells. In addition, co-treatment with nifedipine (100 μM) and FAC (100 μM) increases TfR1, DMT1+IRE and DMT1-IRE expression in WKPT-0293 Cl.2 cells^[2]. Nifedipine plus ritodrine produces a significantly greater inhibition of contractility than each drug alone in the midrange of concentrations. The combination of nifedipine plus nitroglycerin or nifedipine plus atosiban produces a significantly greater inhibition than nitroglycerin or atosiban alone but not greater than nifedipine. The combination of nifedipine plus NS-1619 (Ca²⁺-activated K⁺ [BKCa] channel opener) reduces the inhibitory effect of each drug^[3]. Nifedipine (BAY-a-1040) (2 μM) significantly inhibits P. capsici mycelial growth and sporulation. Nifedipine (BAY-a-1040)-induced inhibition of mycelial growth is calcium-dependent. Nifedipine (0.5 μM) increases P. capsici sensitivity to H₂O₂ in a calcium-dependent manner^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In Nifedipine (BAY-a-1040) (50 mg/kg)- and CsA-treated rats, the BL dimensions (BLi and BLk), MD dimensions (MDk) and vertical dimensions (VHi and VHk) are significantly increased (P < 0.05) at the end of the 4th week^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 21829-25-4
Appearance Solid
Molecular Weight 346.33
Formula C₁₇H₁₈N₂O₆
Color Light yellow to yellow
SMILES

O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2[N+]([O-])=O)OC
Synonyms

BAY-a-1040
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

Publications (28)

All Cell Imaging/StainingOthersBio/Physico-chemical Assay

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Journal Impact Factor

Cell Stem Cell

Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo. [Abstract]

2024 Jan 4;31(1):52-70.e8. PMID: 38181751
Nat Commun

Noncanonical calcium-independent TRPM4 activation governs intestinal fluid homeostasis. [Abstract]

2026 Jan 8;17(1):1253. PMID: 41507162
Sci Adv

A worm-like nucleic acid nanostructure for gene delivery and endosomal escape via ClC3 ion exchanger. [Abstract]

2026 Mar 6;12(10):eadw0891. PMID: 41790895
Biol Psychiatry

Takeda G Protein-Coupled Receptor 5 Modulates Depression-like Behaviors via Hippocampal CA3 Pyramidal Neurons Afferent to Dorsolateral Septum. [Abstract]

2021 Jun 1;89(11):1084-1095. PMID: 33536132
Cell Commun Signal

How filopodia respond to calcium in the absence of a calcium-binding structural protein: non-channel functions of TRP. [Abstract]

2022 Aug 26;20(1):130. PMID: 36028898
Small Sci

Built-In Electric Field Accelerates Nanotopography-Mediated Enhancement of Vascularized Osseointegration via Cav1.2/Piezo/Ca2+/PI3K Signaling. [Abstract]

2025 Jul 14;5(10):2500095. PMID: 41058722
Phytomedicine

Aesculin suppresses the NLRP3 inflammasome-mediated pyroptosis via the Akt/GSK3β/NF-κB pathway to mitigate myocardial ischemia/reperfusion injury. [Abstract]

2021 Nov:92:153687. PMID: 34482222
Alzheimers Res Ther

Ceftriaxone alleviates mitochondrial damage through the inhibition of extrasynaptic NMDA receptor-mediated changes in intracellular calcium levels to improve cognitive deficits in APP/PS1 mice. [Abstract]

2025 Dec 1;17(1):253. PMID: 41327376

Nifedipine purchased from MedChemExpress. Usage Cited in: Alzheimers Res Ther. 2025 Dec 1;17(1):253. [Abstract]

Nifedipine (5 µM, 1 min) decreased the neuronal cytoplasmic Ca²⁺ levels induced by 20 µM glutamate.
J Med Chem

Germacrane Sesquiterpenoids as a New Type of Anticardiac Fibrosis Agent Targeting Transforming Growth Factor β Type I Receptor. [Abstract]

2019 Sep 12;62(17):7961-7975. PMID: 31408333
Sci Signal

Airway relaxation mechanisms and structural basis of osthole for improving lung function in asthma. [Abstract]

2020 Nov 24;13(659):eaax0273. PMID: 33234690

Nifedipine purchased from MedChemExpress. Usage Cited in: Sci Signal. 2020 Nov 24;13(659):eaax0273. [Abstract]

Nifedipine (10 µM, 30 min) relaxed 0.3 μM ACh-constricted mouse airways.

Nifedipine purchased from MedChemExpress. Usage Cited in: Sci Signal. 2020 Nov 24;13(659):eaax0273. [Abstract]

Pretreatment with nifedipine (10 µM, 30 min) reduced ACh-induced airway constriction by about 25% but did not affect osthole-induced relaxation in mouse airways.
Phytother Res

Phenolic acids from Prunella vulgaris alleviate cardiac remodeling following myocardial infarction partially by suppressing NLRP3 activation. [Abstract]

2024 Jan;38(1):384-399. PMID: 37992723
Cell Prolif

Lactate Accelerates Early Angiogenesis and Bone Regeneration Through Macrophage M1 Polarisation. [Abstract]

2026 Jan 26:e70177. PMID: 41587535
Microchem J

2025 Nov 24;220:116331.
Pharmaceuticals (Basel)

In Vivo Antihypertensive and Ex Vivo Vasodilatory Studies of Taxifolin. [Abstract]

2025 Sep 21;18(9):1420. PMID: 41011287

Nifedipine purchased from MedChemExpress. Usage Cited in: Pharmaceuticals (Basel). 2025 Sep 21;18(9):1420. [Abstract]

Nifedipine (0.01 µM, 30 min) inhibited contractions induced by Ca²⁺ influx, keeping the contraction force below 0.1 g even at the highest calcium concentration of 10 mM.
Eur J Pharmacol

Chemerin-9 in paraventricular nucleus increases sympathetic outflow and blood pressure via glutamate receptor-mediated ROS generation. [Abstract]

2022 Dec 5:936:175343. PMID: 36306926
Front Endocrinol

A Type IIb, but Not Type IIa, GnRH Receptor Mediates GnRH-Induced Release of Growth Hormone in the Ricefield Eel. [Abstract]

2018 Nov 30:9:721. PMID: 30555419

Nifedipine purchased from MedChemExpress. Usage Cited in: Front Endocrinol. 2018 Nov 30:9:721. [Abstract]

Nifedipine (4 µM, 4 h) abolished the stimulation of Gh release by GnRH1 or GnRH3 in primary cultured pituitary cells from mixed-sex rice field eels.
ACS Omega

Machine Learning for Discovery of GSK3β Inhibitors. [Abstract]

2020 Oct 12;5(41):26551-26561. PMID: 33110983
FASEB J

Pilocarpine mediated excessive calcium accumulation leads to ciliary muscle cell senescence and apoptosis. [Abstract]

2024 Aug 15;38(15):e23878. PMID: 39120551
Cell Calcium

A NOX2-independent mechanism of Hv1 channel activation promotes inflammatory cytokine release from BV-2 microglia via intracellular Ca2+ mobilisation. [Abstract]

2026 Mar:134:103122. PMID: 41581267
Drug Metab Dispos

Age-dependent pharmacokinetics of nifedipine in spontaneous hypertensive rats are associated with changes in gut microbiota and hepatic CYP3A1 expression. [Abstract]

2025 Aug;53(8):100116. PMID: 40716236
J Cell Commun Signal

Insights into the mediation of Ca2+ signaling in the promoting effects of LETX-VI on the synthesis and release of dopamine. [Abstract]

2023 Dec;17(4):1309-1321. PMID: 37702818
Exp Cell Res

Investigating the effects of TRPV4 and Cav1.2 channels in 3D culture for promoting the differentiation of BMSCs at various stages. [Abstract]

2025 Apr 1;447(1):114515. PMID: 40073957
J Endocrinol Invest

Pannexin-1 regulation of ATP release promotes the invasion of pituitary adenoma. [Abstract]

2025 Feb;48(2):317-332. PMID: 39527372
Neuroscience

The Control of Rat Hippocampal Gamma Oscillation Strength by BK Channel Activity. [Abstract]

2021 Nov 1:475:220-228. PMID: 34509547
J Neurophysiol

Sequential activation of multiple persistent inward currents induces staircase currents in serotonergic neurons of medulla in ePet-EYFP mice. [Abstract]

2020 Jan 1;123(1):277-288. PMID: 31721638
Biol Pharm Bull

Cynaropicrin Increases [Ca2+]i and Ciliary Beat Frequency in Human Airway Epithelial Cells by Inhibiting SERCA. [Abstract]

2024;47(12):2119-2126. PMID: 39710380
Biocell

2026 Jan 23.
medRxiv

2025 May 21.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (288.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8874 mL

14.4371 mL

28.8742 mL

5 mM

0.5775 mL

2.8874 mL

5.7748 mL

10 mM

0.2887 mL

1.4437 mL

2.8874 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (protect from light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protocol

Cell Assay^[2]

Cell viability is assessed using an MTT assay. Briefly, a total of 25 μL MTT (1 g/L in PBS) is added to each well before incubation is conducted at 37°C for 4 h. The assay is stopped by the addition of a 100 μL lysis buffer (20% SDS in 50% N’Ndimethylformamide, pH 4.7). Optical density (OD) is measured at the 570 nm wavelength by the use of an ELX-800 microplate assay reader and the results are expressed as a percentage of the absorbance measured in the control cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration^[1]

All the 30 rats are randomLy distributed into three equal groups of ten animals each. Group 1 (control) receive olive oil for the 8 weeks. Group 2 and Group 3 receive a combination of CsA (30 mg/kg body weight) and Nf (50 mg/kg body weight) in olive oil for 8 weeks. In Group 3 rats, Azi (10 mg/kg body weight) is added to this regimen, in the 5th week. The total study period is 8 weeks.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ratre MS, et al. Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats. J Indian Soc Periodontol. 2016 Jul-Aug;20(4):396-401. [Content Brief]

[2]. Carvajal JA, et al. The Synergic In Vitro Tocolytic Effect of Nifedipine Plus Ritodrine on Human Myometrial Contractility. Reprod Sci. 2017 Apr;24(4):635-640. [Content Brief]

[3]. Yu SS, et al. Nifedipine Increases Iron Content in WKPT-0293 Cl.2 Cells via Up-Regulating Iron Influx Proteins. Front Pharmacol. 2017 Feb 13;8:60 [Content Brief]

[4]. Liu P, et al. The L-type Ca(2+) Channel Blocker Nifedipine Inhibits Mycelial Growth, Sporulation, and Virulence of Phytophthora capsici. Front Microbiol. 2016 Aug 4;7:1236. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8874 mL	14.4371 mL	28.8742 mL	72.1855 mL
	5 mM	0.5775 mL	2.8874 mL	5.7748 mL	14.4371 mL
	10 mM	0.2887 mL	1.4437 mL	2.8874 mL	7.2185 mL
	15 mM	0.1925 mL	0.9625 mL	1.9249 mL	4.8124 mL
	20 mM	0.1444 mL	0.7219 mL	1.4437 mL	3.6093 mL
	25 mM	0.1155 mL	0.5775 mL	1.1550 mL	2.8874 mL
	30 mM	0.0962 mL	0.4812 mL	0.9625 mL	2.4062 mL
	40 mM	0.0722 mL	0.3609 mL	0.7219 mL	1.8046 mL
	50 mM	0.0577 mL	0.2887 mL	0.5775 mL	1.4437 mL
	60 mM	0.0481 mL	0.2406 mL	0.4812 mL	1.2031 mL
	80 mM	0.0361 mL	0.1805 mL	0.3609 mL	0.9023 mL
	100 mM	0.0289 mL	0.1444 mL	0.2887 mL	0.7219 mL

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Nifedipine

Membrane Transporter/Ion Channel Compound Library

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Mass Spectrometry Human Metabolite Library

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Classic FDA-Approved Drug Library

Publications Citing Use of MedChemExpress (MCE) Nifedipine

All Calcium Channel Isoforms

Biological Activity

Chemical Information

Publications (28)

Solvent & Solubility

Protocol

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Nifedipine Related Classifications

Cat. No.: HY-B0284