4-Phenyl-4H-pyrans as IK(Ca) channel blockers

  • Bioorg Med Chem Lett. 2003 Aug 18;13(16):2637-9. doi: 10.1016/s0960-894x(03)00560-2.
Klaus Urbahns  1 ,  Ervin Horváth ,  Johannes Peter Stasch ,  Frank Mauler
Affiliations
  • 1. Institute of Medicinal Chemistry, Pharma Research Center, Bayer AG, D-42096, Wuppertal, Germany. [email protected]
PMID: 12873483 DOI: 10.1016/s0960-894x(03)00560-2
Abstract

4-Phenyl-4H-pyrans have been identified as potent and specific IK(CA) channel blockers. Their synthesis and structure-activity relationships are described. A selected derivative, rac-11, reduces the infarct volume in a rat subdural hematoma model of traumatic brain injury after iv administration.