Nifedipine hydrochloride
Based on 31 publication(s) in Google Scholar
Nifedipine hydrochloride is a potent vasodilator with calcium antagonist activity. Nifedipine hydrochloride is a useful antianginal compound that can also lower blood pressure. Nifedipine hydrochloride exhibits comparable antihypertensive properties to some new compounds, especially in calcium channel blockade. Nifedipine hydrochloride is used in biological activity studies to develop new antihypertensive and/or antianginal compounds.
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- CAS No.: 60299-11-8
- Formule: C17H19ClN2O6
- Masse moléculaire:382.80
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Nifedipine hydrochloride
More- Cell Stem Cell. 2024 Jan 4;31(1):52-70.e8. [Abstract]
- Nat Commun. 2026 Jan 8;17(1):1253. [Abstract]
- Sci Adv. 2026 Mar 6;12(10):eadw0891. [Abstract]
- Cell Commun Signal. 2022 Aug 26;20(1):130. [Abstract]
- Phytomedicine. 2021 Nov:92:153687. [Abstract]
- Cell Death Discov. 2026 Jun 19. [Abstract]
- Biol Psychiatry. 2021 Jun 1;89(11):1084-1095. [Abstract]
- Alzheimers Res Ther. 2025 Dec 1;17(1):253. [Abstract]
- Phytother Res. 2024 Jan;38(1):384-399. [Abstract]
- Cell Prolif. 2026 Jan 26:e70177. [Abstract]
- J Med Chem. 2019 Sep 12;62(17):7961-7975. [Abstract]
- Small Sci. 2025 Jul 14;5(10):2500095. [Abstract]
- Sci Signal. 2020 Nov 24;13(659):eaax0273. [Abstract]
- Pharmaceuticals (Basel). 2025 Sep 21;18(9):1420. [Abstract]
- Eur J Pharmacol. 2022 Dec 5:936:175343. [Abstract]
- Front Endocrinol. 2018 Nov 30:9:721. [Abstract]
- Microchem J. 2025 Nov 24;220:116331.
- ACS Omega. 2020 Oct 12;5(41):26551-26561. [Abstract]
- World J Stem Cells. 2026 May 26;18(5).
- Cell Calcium. 2026 Mar:134:103122. [Abstract]
- FASEB J. 2024 Aug 15;38(15):e23878. [Abstract]
- J Endocrinol Invest. 2025 Feb;48(2):317-332. [Abstract]
- J Cell Commun Signal. 2023 Dec;17(4):1309-1321. [Abstract]
- Drug Metab Dispos. 2025 Aug;53(8):100116. [Abstract]
- Exp Cell Res. 2025 Apr 1;447(1):114515. [Abstract]
- Neuroscience. 2021 Nov 1:475:220-228. [Abstract]
- J Neurophysiol. 2020 Jan 1;123(1):277-288. [Abstract]
- Biocell. 2026 Jan 23.
- Biol Pharm Bull. 2024;47(12):2119-2126. [Abstract]
- bioRxiv. 2026 Jul 10:2026.07.06.736331.
- medRxiv. 2025 May 21.
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Activité biologique
Description
Chemical Information
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CAS No. 60299-11-8
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Masse moléculaire 382.80
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Formule C17H19ClN2O6
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SMILES
O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2[N+]([O-])=O)OC.Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (31)
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Journal Impact Factor
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Most Recent
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Cell Stem Cell
Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo. [Abstract]2024 Jan 4;31(1):52-70.e8. PMID: 38181751 -
Nat Commun
2026 Jan 8;17(1):1253. PMID: 41507162 -
Sci Adv
A worm-like nucleic acid nanostructure for gene delivery and endosomal escape via ClC3 ion exchanger. [Abstract]2026 Mar 6;12(10):eadw0891. PMID: 41790895 -
Cell Commun Signal
How filopodia respond to calcium in the absence of a calcium-binding structural protein: non-channel functions of TRP. [Abstract]2022 Aug 26;20(1):130. PMID: 36028898 -
Phytomedicine
Aesculin suppresses the NLRP3 inflammasome-mediated pyroptosis via the Akt/GSK3β/NF-κB pathway to mitigate myocardial ischemia/reperfusion injury. [Abstract]2021 Nov:92:153687. PMID: 34482222 -
Cell Death Discov
Thioredoxin system dysregulation and calpain activation drive myocardial disulfidptosis via pathological disulfide bonds remodeling. [Abstract]2026 Jun 19. PMID: 42321161 -
Biol Psychiatry
Takeda G Protein-Coupled Receptor 5 Modulates Depression-like Behaviors via Hippocampal CA3 Pyramidal Neurons Afferent to Dorsolateral Septum. [Abstract]2021 Jun 1;89(11):1084-1095. PMID: 33536132 -
Alzheimers Res Ther
Ceftriaxone alleviates mitochondrial damage through the inhibition of extrasynaptic NMDA receptor-mediated changes in intracellular calcium levels to improve cognitive deficits in APP/PS1 mice. [Abstract]2025 Dec 1;17(1):253. PMID: 41327376
Nifedipine hydrochloride purchased from MedChemExpress. Usage Cited in: Alzheimers Res Ther. 2025 Dec 1;17(1):253. [Abstract]
Nifedipine (5 µM, 1 min) decreased the neuronal cytoplasmic Ca2+ levels induced by 20 µM glutamate.
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Phytother Res
Phenolic acids from Prunella vulgaris alleviate cardiac remodeling following myocardial infarction partially by suppressing NLRP3 activation. [Abstract]2024 Jan;38(1):384-399. PMID: 37992723 -
Cell Prolif
Lactate Accelerates Early Angiogenesis and Bone Regeneration Through Macrophage M1 Polarisation. [Abstract]2026 Jan 26:e70177. PMID: 41587535 -
J Med Chem
Germacrane Sesquiterpenoids as a New Type of Anticardiac Fibrosis Agent Targeting Transforming Growth Factor β Type I Receptor. [Abstract]2019 Sep 12;62(17):7961-7975. PMID: 31408333 -
Small Sci
Built-In Electric Field Accelerates Nanotopography-Mediated Enhancement of Vascularized Osseointegration via Cav1.2/Piezo/Ca2+/PI3K Signaling. [Abstract]2025 Jul 14;5(10):2500095. PMID: 41058722 -
Sci Signal
Airway relaxation mechanisms and structural basis of osthole for improving lung function in asthma. [Abstract]2020 Nov 24;13(659):eaax0273. PMID: 33234690
Nifedipine hydrochloride purchased from MedChemExpress. Usage Cited in: Sci Signal. 2020 Nov 24;13(659):eaax0273. [Abstract]
Nifedipine (10 µM, 30 min) relaxed 0.3 μM ACh-constricted mouse airways.
Nifedipine hydrochloride purchased from MedChemExpress. Usage Cited in: Sci Signal. 2020 Nov 24;13(659):eaax0273. [Abstract]
Pretreatment with nifedipine (10 µM, 30 min) reduced ACh-induced airway constriction by about 25% but did not affect osthole-induced relaxation in mouse airways.
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Pharmaceuticals (Basel)
2025 Sep 21;18(9):1420. PMID: 41011287
Nifedipine hydrochloride purchased from MedChemExpress. Usage Cited in: Pharmaceuticals (Basel). 2025 Sep 21;18(9):1420. [Abstract]
Nifedipine (0.01 µM, 30 min) inhibited contractions induced by Ca2+ influx, keeping the contraction force below 0.1 g even at the highest calcium concentration of 10 mM.
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Eur J Pharmacol
Chemerin-9 in paraventricular nucleus increases sympathetic outflow and blood pressure via glutamate receptor-mediated ROS generation. [Abstract]2022 Dec 5:936:175343. PMID: 36306926 -
Front Endocrinol
A Type IIb, but Not Type IIa, GnRH Receptor Mediates GnRH-Induced Release of Growth Hormone in the Ricefield Eel. [Abstract]2018 Nov 30:9:721. PMID: 30555419
Nifedipine hydrochloride purchased from MedChemExpress. Usage Cited in: Front Endocrinol. 2018 Nov 30:9:721. [Abstract]
Nifedipine (4 µM, 4 h) abolished the stimulation of Gh release by GnRH1 or GnRH3 in primary cultured pituitary cells from mixed-sex rice field eels.
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ACS Omega
2020 Oct 12;5(41):26551-26561. PMID: 33110983 -
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Cell Calcium
A NOX2-independent mechanism of Hv1 channel activation promotes inflammatory cytokine release from BV-2 microglia via intracellular Ca2+ mobilisation. [Abstract]2026 Mar:134:103122. PMID: 41581267 -
FASEB J
Pilocarpine mediated excessive calcium accumulation leads to ciliary muscle cell senescence and apoptosis. [Abstract]2024 Aug 15;38(15):e23878. PMID: 39120551 -
J Endocrinol Invest
2025 Feb;48(2):317-332. PMID: 39527372 -
J Cell Commun Signal
Insights into the mediation of Ca2+ signaling in the promoting effects of LETX-VI on the synthesis and release of dopamine. [Abstract]2023 Dec;17(4):1309-1321. PMID: 37702818 -
Drug Metab Dispos
Age-dependent pharmacokinetics of nifedipine in spontaneous hypertensive rats are associated with changes in gut microbiota and hepatic CYP3A1 expression. [Abstract]2025 Aug;53(8):100116. PMID: 40716236 -
Exp Cell Res
Investigating the effects of TRPV4 and Cav1.2 channels in 3D culture for promoting the differentiation of BMSCs at various stages. [Abstract]2025 Apr 1;447(1):114515. PMID: 40073957 -
Neuroscience
2021 Nov 1:475:220-228. PMID: 34509547 -
J Neurophysiol
Sequential activation of multiple persistent inward currents induces staircase currents in serotonergic neurons of medulla in ePet-EYFP mice. [Abstract]2020 Jan 1;123(1):277-288. PMID: 31721638 -
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Biol Pharm Bull
Cynaropicrin Increases [Ca2+]i and Ciliary Beat Frequency in Human Airway Epithelial Cells by Inhibiting SERCA. [Abstract]2024;47(12):2119-2126. PMID: 39710380 -
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Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nifedipine hydrochloride Related Classifications
HY-B0284A Related Classifications
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