1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin
  3. Ganoderic acid D

Ganoderic acid D 

Cat. No.: HY-N1511 Purity: 99.40%
Handling Instructions

Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells.

For research use only. We do not sell to patients.

Ganoderic acid D Chemical Structure

Ganoderic acid D Chemical Structure

CAS No. : 108340-60-9

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10 mM * 1 mL in DMSO USD 147 In-stock
Estimated Time of Arrival: December 31
1 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 130 In-stock
Estimated Time of Arrival: December 31
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Description

Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1].

IC50 & Target[1]

SIRT3

 

In Vitro

Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC50 of 17.3 mM[2].

Molecular Weight

514.65

Formula

C₃₀H₄₂O₇

CAS No.

108340-60-9

SMILES

CC1(C)C(CC[[email protected]]2(C)C3=C([[email protected]@]4(C(C[[email protected]@H]([[email protected]]4(CC3=O)C)[[email protected]](C)CC(CC(C)C(O)=O)=O)=O)C)[[email protected]@H](O)C[[email protected]@]12[H])=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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Ganoderic acid D
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HY-N1511
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