1. Cell Cycle/DNA Damage
    Epigenetics
    Apoptosis
  2. Sirtuin
    Apoptosis
  3. Ganoderic acid D

Ganoderic acid D 

Cat. No.: HY-N1511 Purity: 99.40%
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Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells. Ganoderic acid D induces HeLa human cervical carcinoma apoptosis.

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Ganoderic acid D Chemical Structure

Ganoderic acid D Chemical Structure

CAS No. : 108340-60-9

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Description

Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1]. Ganoderic acid D induces HeLa human cervical carcinoma apoptosis[3].

IC50 & Target[1]

SIRT3

 

In Vitro

Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC50 of 17.3 mM[2]. Ganoderic acid D (1-50 μM; 24-72 hours) reduces the cell survival rate in a dose- and time-dependent manner[3].
Ganoderic acid D (10, 50 μM; 24, 48 hours) induces G2/M phase arrest[3].
Ganoderic acid D (10, 50 μM; 24, 48 hours) induces a morphological change typical of apoptosis in HeLa cells[3].
Ganoderic acid D (10 μM; 48 hours) up-regulates 14-3-3E and PRDX3[3].

Cell Viability Assay[3]

Cell Line: HeLa human cervical carcinoma cell line (CCL-2)
Concentration: 1, 5, 10, 20, 50 μM
Incubation Time: 24, 48, 72 hours
Result: Reduced the cell survival rate in a dose- and time-dependent manner and had an IC50 value of 17.3 μM for 48 hours treatment.

Cell Cycle Analysis[3]

Cell Line: HeLa human cervical carcinoma cell line (CCL-2)
Concentration: 10, 50 μM
Incubation Time: 24, 48 hours
Result: Induced G2/M phase arrest.
Displayed a cell cycle profile with an elevated G2/M cell population after 24-h treatment with 10 μM.

Apoptosis Analysis[3]

Cell Line: HeLa human cervical carcinoma cell line (CCL-2)
Concentration: 10, 50 μM
Incubation Time: 48 hours
Result: Induced a morphological change typical of apoptosis in HeLa cells.

Western Blot Analysis[3]

Cell Line: HeLa human cervical carcinoma cell line (CCL-2)
Concentration: 10 μM
Incubation Time: 48 hours
Result: Up-regulated 14-3-3E and PRDX3.
Molecular Weight

514.65

Formula

C₃₀H₄₂O₇

CAS No.

108340-60-9

SMILES

CC1(C)C(CC[[email protected]]2(C)C3=C([[email protected]@]4(C(C[[email protected]@H]([[email protected]]4(CC3=O)C)[[email protected]](C)CC(CC(C)C(O)=O)=O)=O)C)[[email protected]@H](O)C[[email protected]@]12[H])=O

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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

Ganoderic acid DSirtuinApoptosisoxygenatedtetracyclictriterpenoiddeacetylatedcyclophilinDCypDcoloncancerHeLahumancervicalcarcinomaInhibitorinhibitorinhibit

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Ganoderic acid D
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