1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin
  3. Ganoderic acid D

Ganoderic acid D 

Cat. No.: HY-N1511
Handling Instructions

Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells. Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC50 of 17.3 mM.

For research use only. We do not sell to patients.

Ganoderic acid D Chemical Structure

Ganoderic acid D Chemical Structure

CAS No. : 108340-60-9

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Description

Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1]. Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC50 of 17.3 mM[2].

IC50 & Target[1]

SIRT3

 

Molecular Weight

514.65

Formula

C₃₀H₄₂O₇

CAS No.

108340-60-9

SMILES

CC1(C)C(CC[[email protected]]2(C)C3=C([[email protected]@]4(C(C[[email protected]@H]([[email protected]]4(CC3=O)C)[[email protected]](C)CC(CC(C)C(O)=O)=O)=O)C)[[email protected]@H](O)C[[email protected]@]12[H])=O

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Ganoderic acid D
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HY-N1511
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