1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin
  3. SRT 2104

SRT 2104 

Cat. No.: HY-15262 Purity: 98.87%
Handling Instructions

SRT 2104 is a first-in-class, highly selective and brain-permeable activator of the NAD+ dependent deacetylase Sirt1, increases Sirt1 protein, but shows no effect on Sirt1 mRNA. Used in the research of diabetes mellitus and Huntington’s disease.

For research use only. We do not sell to patients.

SRT 2104 Chemical Structure

SRT 2104 Chemical Structure

CAS No. : 1093403-33-8

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Customer Review

Based on 5 publication(s) in Google Scholar

Top Publications Citing Use of Products

    SRT 2104 purchased from MCE. Usage Cited in: J Mol Med (Berl). 2018 Sep;96(9):939-949.

    To test the effect of miR-34a inhibition and SIRT1 activation on the expression of miR-34a and Sirt1, the diabetic mice are treated with NC-I, miR-34a-I or SRT2104. Sirt1 mRNA levels are determined by qPCR.

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    Description

    SRT 2104 is a first-in-class, highly selective and brain-permeable activator of the NAD+ dependent deacetylase Sirt1, increases Sirt1 protein, but shows no effect on Sirt1 mRNA. Used in the research of diabetes mellitus and Huntington’s disease[1][2][3].

    IC50 & Target[1]

    SIRT1

     

    In Vivo

    SRT 2104 (100 mg/kg/day, supplemented in diet for 24 weeks) increases SIRT1 protein without altering Sirt1 mRNA in diabetic mice[2].
    SRT 2104 (100 mg/kg/day, supplemented in diet for 24 weeks) decreases testicular oxidative stress, activation of apoptotic signaling, and ER stress in diabetic mice[2].
    SRT 2104 (0.5%; for 18 weeks) improves motor function and increases survival in N171-82Q HD mice[3].

    Animal Model: Male C57BL/6 mice (8-week-old)[2]
    Dosage: 100 mg/kg/day
    Administration: Supplemented in diet for 24 weeks
    Result: Enhanced SIRT1 protein without evelating Sirt1 mRNA level. Attenuated diabetes mellitus (DM)-induced oxidative stress, apoptotic signaling, and ER stress.
    Animal Model: WT and N171-82Q HD mice (6 weeks old)[3]
    Dosage: 0.5%
    Administration: 0.5% SRT 2104 containing diet for 6, 12, 18 weeks
    Result: Ameliorated motor deficits and increased survival in N171-82Q HD mice.
    Clinical Trial
    Molecular Weight

    516.64

    Formula

    C₂₆H₂₄N₆O₂S₂

    CAS No.

    1093403-33-8

    SMILES

    O=C(C1=C(C)N=C(C2=CC=CN=C2)S1)NC3=CC=CC=C3C4=CN5C(SC=C5CN6CCOCC6)=N4

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 5 mg/mL (9.68 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9356 mL 9.6779 mL 19.3558 mL
    5 mM 0.3871 mL 1.9356 mL 3.8712 mL
    10 mM --- --- ---
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 0.5 mg/mL (0.97 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 0.5 mg/mL (0.97 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 98.87%

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    Product Name:
    SRT 2104
    Cat. No.:
    HY-15262
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