1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin

SRT 2104 

Cat. No.: HY-15262 Purity: 98.87%
Handling Instructions

SRT 2104 is a brain-permeable activator of SIRT1, used for the research of type 2 diabetes mellitus and Huntington's disease.

For research use only. We do not sell to patients.

SRT 2104 Chemical Structure

SRT 2104 Chemical Structure

CAS No. : 1093403-33-8

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Top Publications Citing Use of Products

    SRT 2104 purchased from MCE. Usage Cited in: J Mol Med (Berl). 2018 Sep;96(9):939-949.

    To test the effect of miR-34a inhibition and SIRT1 activation on the expression of miR-34a and Sirt1, the diabetic mice are treated with NC-I, miR-34a-I or SRT2104. Sirt1 mRNA levels are determined by qPCR.

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    • Biological Activity

    • Protocol

    • Technical Information

    • Purity & Documentation

    • References

    Description

    SRT 2104 is a brain-permeable activator of SIRT1, used for the research of type 2 diabetes mellitus and Huntington's disease.

    IC50 & Target[1]

    SIRT1

     

    In Vitro

    SRT 2104 (3 μM) reduces p65/RelA acetylation levels in C2C12 cells[1].

    In Vivo

    SRT2104 (100 mg/kg, p.o.) improves whole-body physiology and extends lifespan in mice fed a standard diet. SRT2104 increases mitochondrial content and suppresses the inflammatory response in SD-fed mice. SRT2104 also changes the gene expression profile differently in liver and muscle. Short-term SRT2104 preserves muscle and bone mass[1]. 0.5% SRT2104 diet penetrates the blood-brain barrier, attenuates brain atrophy, improves motor function, and extends survival in a mouse model of Huntington's disease[2].

    Clinical Trial
    Solvent & Solubility
    In Vitro: 

    DMSO : 5 mg/mL (9.68 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9356 mL 9.6779 mL 19.3558 mL
    5 mM 0.3871 mL 1.9356 mL 3.8712 mL
    10 mM 0.1936 mL 0.9678 mL 1.9356 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 0.5 mg/mL (0.97 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 0.5 mg/mL (0.97 mM); Clear solution

    References
    Cell Assay
    [1]

    C2C12 cell line is cultured in low glucose Dulbecco’s modified Eagle’s medium (DMEM) supplemented with 10% fetal bovine serum (FBS) and penicillin-streptomycin. Cells are treated with vehicle (0.1% DMSO) or 3 μm SRT2104 for 24 h and then harvested for protein and Western blotting[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Administration
    [1]

    For the longevity study, diets are started at 28 weeks of age after randomization into two groups of 100 mice per group. Mice are fed a standard AIN-93G diet (SD; carbohydrate:protein:fat ratio of 64:19:17 percent of kcal), or a SD supplemented with SRT2104. SRT2104 is added at a dose of 1.33 g drug per kg of chow, formulated to provide daily doses of 100 mg drug/kg bodyweight. For the hindlimb suspension study, starting at 4 months of age, C57BL/6 mice are fed either a standard AIN-93G diet (SD; carbohydrate:protein:fat ratio of 64:19:17 percent of kcal) or a SD supplemented with SRT2104 for 4 weeks prior to suspension, and then for an additional 2 weeks during the suspension. Diets are formulated so mice receive a daily dose of 200 mg drug/kg of bodyweight. For the 48-h fasting study, mice are fed either SD or a SD supplemented with SRT2104 (100 mg/kg) for 6 weeks prior to sacrifice. This is the same diet as for the longevity study mice. For the whole-body SIRT1 knockout and muscle-specific SIRT1 knockout mouse models, mice are maintained on house chow (carbohydrate:protein:fat ratio of 58:24:18 percent of kcal) for the course of their lives[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
    Molecular Weight

    516.64

    Formula

    C₂₆H₂₄N₆O₂S₂

    CAS No.

    1093403-33-8

    SMILES

    O=C(C1=C(C)N=C(C2=CC=CN=C2)S1)NC3=CC=CC=C3C4=CN5C(SC=C5CN6CCOCC6)=N4

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 98.87%

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    Product Name:
    SRT 2104
    Cat. No.:
    HY-15262
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    SRT 2104

    Cat. No.: HY-15262