1. Apoptosis Autophagy Metabolic Enzyme/Protease
  2. Apoptosis Autophagy Endogenous Metabolite
  3. Ganoderic acid A

Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS.

For research use only. We do not sell to patients.

Ganoderic acid A Chemical Structure

Ganoderic acid A Chemical Structure

CAS No. : 81907-62-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 138 In-stock
Solution
10 mM * 1 mL in DMSO USD 138 In-stock
Solid
1 mg USD 50 In-stock
5 mg USD 125 In-stock
10 mg USD 200 In-stock
25 mg USD 320 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 7 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Ganoderic acid A purchased from MedChemExpress. Usage Cited in: J Biochem Mol Toxicol. 2019 Nov;33(11):e22392.  [Abstract]

    Western blot analysis determined the expression levels of AKT, p-AKT, mTOR, p-mTOR, p-P70S6K, and cyclin D1 after GA-A treatment.

    Ganoderic acid A purchased from MedChemExpress. Usage Cited in: J Biochem Mol Toxicol. 2019 Nov;33(11):e22392.  [Abstract]

    GA-A decreases the migration and invasion of GBM cells using transwell assay. U251 cells treated with GA-A, as experimental group. U251 cells treated with DMSO, as the negative control group (NC). GA-A obviously reduces the number of invaded U251 cells that goes through the Matrigel. GA-A markedly decreases the number of migrated cell that crossed the chamber. GA-A, ganoderic acid A; GBM, human glioblastoma. *P < .05 compared to NC.

    Ganoderic acid A purchased from MedChemExpress. Usage Cited in: J Biochem Mol Toxicol. 2019 Nov;33(11):e22392.  [Abstract]

    Western blot assay detects the apoptosis related protein expression. U251 cells treated with GA-A, as experimental group. U251 cells treated with DMSO, as negative control group (NC).
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS.

    In Vitro

    A lower doses of Ganoderic acid A enhance HLA class II-mediated antigen presentation and CD4+ T cell recognition of lymphoma[1].
    Ganoderic acid A promots cisplatin-induced cell death by enhancing the sensitivity of HepG2 cells to cisplatin mainly via the signal transducer and activator of transcription 3 suppression[2].
    Ganoderic acid Ainhibits proliferation, viability, ROS, DPPH, and analyzed the expression of SOD1, SOD2, and SOD3 by Real time PCR in a PC-3 cell in a dose-dependent manner[3].
    Ganoderic acid A effectively inhibites the proliferation of human osteosarcoma HOS and MG-63 cells in a dose-dependent manner, and induced obvious cell apoptosis in both cells[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Ganoderic acid A treatment significantly prolonged survival of EL4 challenged mice and decreased tumor metastasis to the liver[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    516.67

    Formula

    C30H44O7

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CC1(C)C(CC[C@]2(C)C3=C([C@@]4([C@@H](O)C[C@@H]([C@]4(CC3=O)C)[C@H](C)CC(C[C@@H](C)C(O)=O)=O)C)[C@@H](O)C[C@@]12[H])=O

    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 62.5 mg/mL (120.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Ethanol : ≥ 50 mg/mL (96.77 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9355 mL 9.6774 mL 19.3547 mL
    5 mM 0.3871 mL 1.9355 mL 3.8709 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture and light). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (4.03 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (4.03 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture and light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.84%

    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture and light). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    Ethanol / DMSO 1 mM 1.9355 mL 9.6774 mL 19.3547 mL 48.3868 mL
    5 mM 0.3871 mL 1.9355 mL 3.8709 mL 9.6774 mL
    10 mM 0.1935 mL 0.9677 mL 1.9355 mL 4.8387 mL
    15 mM 0.1290 mL 0.6452 mL 1.2903 mL 3.2258 mL
    20 mM 0.0968 mL 0.4839 mL 0.9677 mL 2.4193 mL
    25 mM 0.0774 mL 0.3871 mL 0.7742 mL 1.9355 mL
    30 mM 0.0645 mL 0.3226 mL 0.6452 mL 1.6129 mL
    40 mM 0.0484 mL 0.2419 mL 0.4839 mL 1.2097 mL
    50 mM 0.0387 mL 0.1935 mL 0.3871 mL 0.9677 mL
    60 mM 0.0323 mL 0.1613 mL 0.3226 mL 0.8064 mL
    80 mM 0.0242 mL 0.1210 mL 0.2419 mL 0.6048 mL
    DMSO 100 mM 0.0194 mL 0.0968 mL 0.1935 mL 0.4839 mL
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    Ganoderic acid A
    Cat. No.:
    HY-N1447
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