1. Apoptosis
    Autophagy
    Metabolic Enzyme/Protease
  2. Apoptosis
    Autophagy
    Endogenous Metabolite
  3. Ganoderic acid A

Ganoderic acid A 

Cat. No.: HY-N1447 Purity: 99.20%
COA Handling Instructions

Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS.

For research use only. We do not sell to patients.

Ganoderic acid A Chemical Structure

Ganoderic acid A Chemical Structure

CAS No. : 81907-62-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 138 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 138 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 125 In-stock
Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
25 mg USD 320 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 6 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Ganoderic acid A purchased from MCE. Usage Cited in: J Biochem Mol Toxicol. 2019 Nov;33(11):e22392.  [Abstract]

    GA-A decreases the migration and invasion of GBM cells using transwell assay. U251 cells treated with GA-A, as experimental group. U251 cells treated with DMSO, as the negative control group (NC). GA-A obviously reduces the number of invaded U251 cells that goes through the Matrigel. GA-A markedly decreases the number of migrated cell that crossed the chamber. GA-A, ganoderic acid A; GBM, human glioblastoma. *P < .05 compared to NC.

    Ganoderic acid A purchased from MCE. Usage Cited in: J Biochem Mol Toxicol. 2019 Nov;33(11):e22392.  [Abstract]

    Western blot assay detects the apoptosis related protein expression. U251 cells treated with GA-A, as experimental group. U251 cells treated with DMSO, as negative control group (NC).

    Ganoderic acid A purchased from MCE. Usage Cited in: J Biochem Mol Toxicol. 2019 Nov;33(11):e22392.  [Abstract]

    Western blot analysis determined the expression levels of AKT, p-AKT, mTOR, p-mTOR, p-P70S6K, and cyclin D1 after GA-A treatment.
    • Biological Activity

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    • Customer Review

    Description

    Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS.

    In Vitro

    A lower doses of Ganoderic acid A enhance HLA class II-mediated antigen presentation and CD4+ T cell recognition of lymphoma[1].
    Ganoderic acid A promots cisplatin-induced cell death by enhancing the sensitivity of HepG2 cells to cisplatin mainly via the signal transducer and activator of transcription 3 suppression[2].
    Ganoderic acid Ainhibits proliferation, viability, ROS, DPPH, and analyzed the expression of SOD1, SOD2, and SOD3 by Real time PCR in a PC-3 cell in a dose-dependent manner[3].
    Ganoderic acid A effectively inhibites the proliferation of human osteosarcoma HOS and MG-63 cells in a dose-dependent manner, and induced obvious cell apoptosis in both cells[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Ganoderic acid A treatment significantly prolonged survival of EL4 challenged mice and decreased tumor metastasis to the liver[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    516.67

    Formula

    C30H44O7

    CAS No.
    SMILES
    Structure Classification
    Source
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 62.5 mg/mL (120.97 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9355 mL 9.6774 mL 19.3547 mL
    5 mM 0.3871 mL 1.9355 mL 3.8709 mL
    10 mM 0.1935 mL 0.9677 mL 1.9355 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (4.03 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (4.03 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (4.03 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.84%

    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    Ganoderic acid A
    Cat. No.:
    HY-N1447
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