1. Apoptosis
    Autophagy
  2. Apoptosis
    Autophagy
  3. Ganoderic acid A

Ganoderic acid A 

Cat. No.: HY-N1447 Purity: 99.84%
Handling Instructions

Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS.

For research use only. We do not sell to patients.

Ganoderic acid A Chemical Structure

Ganoderic acid A Chemical Structure

CAS No. : 81907-62-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 246 In-stock
Estimated Time of Arrival: December 31
1 mg USD 96 In-stock
Estimated Time of Arrival: December 31
5 mg USD 216 In-stock
Estimated Time of Arrival: December 31
10 mg USD 276 In-stock
Estimated Time of Arrival: December 31
25 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Ganoderic acid A

    Ganoderic acid A purchased from MCE. Usage Cited in: J Biochem Mol Toxicol. 2019 Sep 10:e22392. 

    GA-A decreases the migration and invasion of GBM cells using transwell assay. U251 cells treated with GA-A, as experimental group. U251 cells treated with DMSO, as the negative control group (NC). GA-A obviously reduces the number of invaded U251 cells that goes through the Matrigel. GA-A markedly decreases the number of migrated cell that crossed the chamber. GA-A, ganoderic acid A; GBM, human glioblastoma. *P < .05 compared to NC.

    Ganoderic acid A purchased from MCE. Usage Cited in: J Biochem Mol Toxicol. 2019 Sep 10:e22392. 

    Western blot assay detects the apoptosis related protein expression. U251 cells treated with GA-A, as experimental group. U251 cells treated with DMSO, as negative control group (NC).

    Ganoderic acid A purchased from MCE. Usage Cited in: J Biochem Mol Toxicol. 2019 Sep 10:e22392. 

    Western blot analysis determined the expression levels of AKT, p-AKT, mTOR, p-mTOR, p-P70S6K, and cyclin D1 after GA-A treatment.
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    Description

    Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS.

    In Vitro

    A lower doses of Ganoderic acid A enhance HLA class II-mediated antigen presentation and CD4+ T cell recognition of lymphoma[1].
    Ganoderic acid A promots cisplatin-induced cell death by enhancing the sensitivity of HepG2 cells to cisplatin mainly via the signal transducer and activator of transcription 3 suppression[2].
    Ganoderic acid Ainhibits proliferation, viability, ROS, DPPH, and analyzed the expression of SOD1, SOD2, and SOD3 by Real time PCR in a PC-3 cell in a dose-dependent manner[3].
    Ganoderic acid A effectively inhibites the proliferation of human osteosarcoma HOS and MG-63 cells in a dose-dependent manner, and induced obvious cell apoptosis in both cells[4].

    In Vivo

    Ganoderic acid A treatment significantly prolonged survival of EL4 challenged mice and decreased tumor metastasis to the liver[4].

    Molecular Weight

    516.67

    Formula

    C₃₀H₄₄O₇

    CAS No.

    81907-62-2

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 29 mg/mL (56.13 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9355 mL 9.6774 mL 19.3547 mL
    5 mM 0.3871 mL 1.9355 mL 3.8709 mL
    10 mM 0.1935 mL 0.9677 mL 1.9355 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.17 mg/mL (4.20 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 3.94 mg/mL (7.63 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.17 mg/mL (4.20 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    Ganoderic acid AApoptosisAutophagyInhibitorinhibitorinhibit

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    Product name:
    Ganoderic acid A
    Cat. No.:
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