2. Others Metabolic Enzyme/Protease
  3. Environmental Pollutants Endogenous Metabolite
  4. Laminaran

Laminaran is an β-1-3-glucan and a typical ligand for Dectin-1 from Eisenia Bicyclis, has potent immunomodulating, radioprotective, and anticancer activities. Laminaran is made up of β (1→3)-glucan with β (1→6)-branches and can be catalyzed by enzymes such as laminarinase (EC 3.2.1.6) that breaks the β (1→3) bonds. Laminaran is a promising immune stimulatory molecule for use in cancer immunotherapy.

For research use only. We do not sell to patients.

CAS No. : 9008-22-4

Size Price Stock Quantity
100 mg In-stock
500 mg Get quote
1 g Get quote
5 g   Get quote  
10 g   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Laminaran Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Laminaran

Bio/Physico-chemical Assay
RT-PCR
ELISA
Histological Imaging/Staining

    Laminaran purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 9:147:114014.  [Abstract]

    Laminaran (100 μM) treatment significantly increased the HTDNA-induced expression of IFNB in Hela cells.

    Laminaran purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 9:147:114014.  [Abstract]

    Laminaran (50-500 µM; 6 h) increased mRNA expression level of IFNB in THP-1 cells stimulated with HTDNA.

    Laminaran purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 9:147:114014.  [Abstract]

    Laminaran (100 µM; 6 h) increased IFN-β production in THP-1 cells stimulated with HTDNA.

    Laminaran purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 9:147:114014.  [Abstract]

    Laminaran (100 µM; 6 h) increased mRNA expression levels of CXCL10 and ISG56 in THP-1 cells stimulated with HTDNA.

    Laminaran purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 9:147:114014.  [Abstract]

    Laminaran (25 mg/kg; i.v.; once daily for 3 weeks) decreased inflammatory cell infiltration and tissue damage in the lung of C57BL/6J mice after HSV-1 infection.

    View All Endogenous Metabolite Isoform Specific Products:

    View All Isoforms
    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Laminaran is an β-1-3-glucan and a typical ligand for Dectin-1 from Eisenia Bicyclis, has potent immunomodulating, radioprotective, and anticancer activities[1]. Laminaran is made up of β (1→3)-glucan with β (1→6)-branches and can be catalyzed by enzymes such as laminarinase (EC 3.2.1.6) that breaks the β (1→3) bonds[2]. Laminaran is a promising immune stimulatory molecule for use in cancer immunotherapy[3].

    In Vitro

    Laminaran (100-800 μg/mL; 24 hours) is not cytotoxic against normal epidermal cells JB6 Cl41 and human melanoma cells SK-MEL-28, the percentage of inhibition of living cells number is less than 15 % at concentrations range up to 800 μg/mL after 24 h of treatment[1].
    Laminaran (200 μg/mL; 24-72 hours)does not cause any growth inhibition of SK-MEL-28 cells after 24 and 48 h of treatment, but decreases cells proliferation by 36 % after 72 h of treatment[1].
    Laminaran (25-50 μg/mL; 24 hours) at low concentration does not influence the phosphorylation of c-Raf (Ser259), ERK1/2 (Tyr202/Tyr204), and MEK1/2 (Ser 221) kinases as well as total expression level of investigated proteins. But decreases p-MEK, p-ERK1/2 at 50 μg/mL[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Laminaran Related Antibodies

    Cell Viability Assay[1]

    Cell Line: JB6 Cl41 and SK-MEL-28 cells
    Concentration: 100, 200, 400, and 800 µg/mL
    Incubation Time: 24 hours
    Result: Showed no cytotoxic against normal epidermal cells JB6 Cl41 and human melanoma cells SK-MEL-28.

    Cell Proliferation Assay[1]

    Cell Line: SK-MEL-28 cells
    Concentration: 200 µg/mL
    Incubation Time: 24 hours
    Result: Decreased cell proliferation at 72 hours.

    Western Blot Analysis[1]

    Cell Line: SK-MEL-28 cells
    Concentration: 25 µg/mL; 50 µg/mL
    Incubation Time: 24 hours
    Result: Inhibited phosphorylation of c-Raf, MEK1/2, and ERK1/2 kinases.
    In Vivo

    Laminaran (intravenous injection; 12.5, 25, and 50 mg/kg; 21 days) and OVA (50 μg) combination significanly decreases the tumor masses when it compares with the PBS-, OVA-, and laminarin-treated mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C57BL/6 mice injected s.c. with B16-OVA cells[3]
    Dosage: 12.5, 25, and 50 mg/kg; 21 days
    Administration: Intravenous injection
    Result: Prevented B16-OVA tumor growth by inducing Ag-specific immune responses.
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    [Laminaran]
    Structure Classification
    Initial Source

    Eisenia Bicyclis
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 16.67 mg/mL (Need ultrasonic)

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 33.33 mg/mL; Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    SDS (252 KB)

    COA (241 KB)

    Handling Instructions (2659 KB)
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Laminaran Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Laminaran9008-22-4Environmental PollutantsEndogenous MetaboliteEnvironmental ContaminantsImmunomodulatingradioprotectiveanticancerimmunotherapytumorInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Laminaran
    Cat. No.:
    HY-119109
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.