1. MAPK/ERK Pathway
  2. Raf
  3. c-Raf Inhibitors

c-Raf Inhibitors

BRaf

c-Raf

Raf

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Sorry. There is currently no product that acts on isoform c-Raf together.

Please try each isoform separately.

c-Raf Specific Inhibitors
Product Name c-Raf BRaf c-Raf Selectivity Purity
GW 5074
c-Raf, IC50: 9 nM
  Selective Inhibitor 98.77%
ZM 336372
c-Raf, IC50: 0.07 μM (0.1 mM ATP)
  Selective Inhibitor 96.79%
Sorafenib
Raf-1, IC50: 6 nM
Braf, IC50: 22 nM
BrafV599E, IC50: 38 nM
Pan Inhibitor 99.92%
Vemurafenib
c-Raf-1, IC50: 48 nM
B-RafV600E, IC50: 31 nM
Pan Inhibitor 99.73%
Dabrafenib
CRAF, IC50: 5 nM
BRafV600E, IC50: 0.6 nM
Pan Inhibitor 99.72%
Sorafenib Tosylate
Raf-1, IC50: 6 nM
Braf, IC50: 22 nM
BrafV599E, IC50: 38 nM
Pan Inhibitor 99.53%
Belvarafenib
CRAF, IC50: 5 nM
BRafV600E, IC50: 7 nM
B-Raf, IC50: 56 nM
Pan Inhibitor
AZ304
CRAF, IC50: 68 nM
BRafV600E, IC50: 38 nM
BRAFWT, IC50: 79 nM
Pan Inhibitor 99.39%
LY3009120
CRAF, IC50: 15 nM
BRafV600E, IC50: 5.8 nM
Braf, IC50: 9.1 nM
Pan Inhibitor 98.31%
Dabrafenib Mesylate
CRAF, IC50: 5 nM
BRafV600E, IC50: 0.6 nM
Pan Inhibitor 99.94%
LXH254
c-Raf
Braf
Pan Inhibitor 99.94%
RAF709
CRAF, IC50: 0.5 nM
Braf, IC50: 0.4 nM
Pan Inhibitor 99.55%
Agerafenib
CRAF, Kd: 39 nM
Braf, Kd: 36 nM
BRafV600E, Kd: 14 nM
Pan Inhibitor 99.20%
AZ 628
c-Raf-1, IC50: 29 nM
B-Raf, IC50: 105 nM
B-RafV600E, IC50: 34 nM
Pan Inhibitor 99.56%
Regorafenib Hydrochloride
Raf-1, IC50: 2.5 nM
BRafV600E, IC50: 19 nM
Braf, IC50: 28 nM
Pan Inhibitor 98.65%
Ro 5126766
CRAF, IC50: 56 nM
BRafV600E, IC50: 8.2 nM
Braf, IC50: 190 nM
Pan Inhibitor 97.92%
CCT196969
CRAF, IC50: 0.01 μM
BRafV600E, IC50: 0.04 μM
Braf, IC50: 0.1 μM
Pan Inhibitor 99.04%
Regorafenib monohydrate
Raf-1, IC50: 2.5 nM
BRafV600E, IC50: 19 nM
Braf, IC50: 28 nM
Pan Inhibitor 99.94%
SB-590885
c-Raf, Ki: 1.72 nM
B-Raf, Ki: 0.16 nM
Pan Inhibitor 99.03%
B-Raf inhibitor 1
c-Raf, Ki: 0.3 nM
B-Raf, Ki: 1 nM
B-RafV600E, Ki: 1 nM
Pan Inhibitor 97.76%
Agerafenib hydrochloride
CRAF, Kd: 39 nM
BRafV600E, Kd: 14 nM
Braf, Kd: 36 nM
Pan Inhibitor
B-Raf inhibitor 1 dihydrochloride
c-Raf, Ki: 0.3 nM
B-Raf, Ki: 1 nM
B-RafV600E, Ki: 1 nM
Pan Inhibitor