1. MAPK/ERK Pathway
  2. Raf
  3. Belvarafenib

Belvarafenib 

Cat. No.: HY-109080
Handling Instructions

Belvarafenib is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.

For research use only. We do not sell to patients.

Belvarafenib Chemical Structure

Belvarafenib Chemical Structure

CAS No. : 1446113-23-0

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Description

Belvarafenib is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.

IC50 & Target

BRafV600E

7 nM (IC50)

CRAF

5 nM (IC50)

B-Raf

56 nM (IC50)

In Vitro

Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively[1].

Molecular Weight

478.93

Formula

C₂₃H₁₆ClFN₆OS

CAS No.

1446113-23-0

SMILES

O=C(C(C1=NC=N2)=CSC1=C2N)NC(C3=C4C(NC(C=CC=C5Cl)=C5F)=NC=C3)=C(C=C4)C

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Belvarafenib
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