1. MAPK/ERK Pathway
  2. Raf
  3. Belvarafenib TFA

Belvarafenib TFA (Synonyms: HM95573 TFA; GDC-5573 TFA; RG6185 TFA)

Cat. No.: HY-109080A Purity: >99.0%
Handling Instructions

Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.

For research use only. We do not sell to patients.

Belvarafenib TFA Chemical Structure

Belvarafenib TFA Chemical Structure

Size Price Stock
10 mM * 1  mL in Water USD 457 Ask For Quote & Lead Time
5 mg USD 350 Ask For Quote & Lead Time

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Description

Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively[1].

IC50 & Target

IC50: 56 nM(B-RAF), 7 nM(B-RAFv600E), 5 nM(C-RAF)[1].

In Vitro

Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively[1].

Clinical Trial
Molecular Weight

592.95

Formula

C₂₅H₁₇ClF₄N₆O₃S

SMILES

O=C(C(C1=NC=N2)=CSC1=C2N)NC(C3=C4C(NC(C=CC=C5Cl)=C5F)=NC=C3)=C(C=C4)C.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

BelvarafenibHM95573GDC-5573RG6185HM 95573HM-95573GDC5573GDC 5573RG 6185RG-6185RafRaf kinasesInhibitorinhibitorinhibit

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Belvarafenib TFA
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