1. MAPK/ERK Pathway
  2. Raf
  3. Belvarafenib TFA

Belvarafenib TFA  (Synonyms: HM95573 TFA; GDC-5573 TFA; RG6185 TFA)

Cat. No.: HY-109080A
COA Handling Instructions

Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.

For research use only. We do not sell to patients.

Belvarafenib TFA Chemical Structure

Belvarafenib TFA Chemical Structure

CAS No. : 2443966-84-3

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Description

Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively[1].

IC50 & Target

IC50: 56 nM(B-RAF), 7 nM(B-RAFv600E), 5 nM(C-RAF)[1].

In Vitro

Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

592.95

Formula

C25H17ClF4N6O3S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C1=NC=N2)=CSC1=C2N)NC(C3=C4C(NC(C=CC=C5Cl)=C5F)=NC=C3)=C(C=C4)C.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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Belvarafenib TFA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Belvarafenib TFA
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HY-109080A
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