Belvarafenib TFA  (Synonyms: HM95573 TFA; GDC-5573 TFA; RG6185 TFA)

Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC₅₀s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv^600E and C-RAF respectively^[1].

IC50: 56 nM(B-RAF), 7 nM(B-RAFv^600E), 5 nM(C-RAF)^[1].

Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC₅₀ values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv^600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC₅₀s of 10 nM, 23 nM and 44 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

592.95

C₂₅H₁₇ClF₄N₆O₃S

2443966-84-3

Solid

White to off-white

O=C(C(C1=NC=N2)=CSC1=C2N)NC(C3=C4C(NC(C=CC=C5Cl)=C5F)=NC=C3)=C(C=C4)C.OC(C(F)(F)F)=O

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. WO 2013/100632 A1.