Belvarafenib TFA
Based on 6 publication(s) in Google Scholar
Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.
For research use only. We do not sell to patients.
- CAS No.: 2443966-84-3
- Formula: C25H17ClF4N6O3S
- Molecular Weight:592.95
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Belvarafenib TFA
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Biological Activity
IC50: 56 nM(B-RAF), 7 nM(B-RAFv600E), 5 nM(C-RAF)[1].
Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2443966-84-3
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Appearance Solid
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Molecular Weight 592.95
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Formula C25H17ClF4N6O3S
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Color White to off-white
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SMILES
O=C(C(C1=NC=N2)=CSC1=C2N)NC(C3=C4C(NC(C=CC=C5Cl)=C5F)=NC=C3)=C(C=C4)C.OC(C(F)(F)F)=O
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Synonyms
HM95573 TFA; GDC-5573 TFA; RG6185 TFA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
mTOR inhibition enhances the antitumor efficacy of pan-RAF-MEK blockade by inhibiting the ATF4-MTHFD2 pathway. [Abstract]2026 May 6;17(1):600. PMID: 42091854 -
Proc Natl Acad Sci U S A
2023 Oct 10;120(41):e2308635120. PMID: 37782788 -
J Invest Dermatol
Combined Inhibition of MNK Signaling and BET Proteins Reveals TGM2 as a Novel Vulnerability in Melanoma. [Abstract]2025 Apr;145(4):979-984.e5. PMID: 39357785 -
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Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. WO 2013/100632 A1.
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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