2443966-84-3
2443966-84-3
Chemical Structure
Belvarafenib TFA
Synonym(s): HM95573 TFA; GDC-5573 TFA; RG6185 TFA
- CAS No.: 2443966-84-3
- Formula:C25H17ClF4N6O3S
- Molecular Weight:592.95
IUPAC Name: 4-amino-N-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide 2,2,2-trifluoroacetate
InChIKey: MUFMPRYDZZISSM-UHFFFAOYSA-N
SMILES: O=C(C(C1=NC=N2)=CSC1=C2N)NC(C3=C4C(NC(C=CC=C5Cl)=C5F)=NC=C3)=C(C=C4)C.OC(C(F)(F)F)=O
Biological Activity: Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively[1].
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Belvarafenib TFA | Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. | |||||||||||||||||||||
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