946128-88-7
946128-88-7
Chemical Structure
Avutometinib
Synonym(s): Ro 5126766; CH5126766
- CAS No.: 946128-88-7
- Formula:C21H18FN5O5S
- Molecular Weight:471.46
InChIKey: LMMJFBMMJUMSJS-UHFFFAOYSA-N
SMILES: O=S(NC)(NC1=NC=CC(CC2=C(C)C3=CC=C(OC4=NC=CC=N4)C=C3OC2=O)=C1F)=O
Biological Activity: Avutometinib (Ro 5126766) is a first-in-class dual MEK/RAF inhibitor that allosterically inhibits BRAFV600E, CRAF, MEK, and BRAF (IC50: 8.2, 56, 160 nM, and 190 nM, respectively).
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Avutometinib | 99.43% | Avutometinib (Ro 5126766) is a first-in-class dual MEK/RAF inhibitor that allosterically inhibits BRAFV600E, CRAF, MEK, and BRAF (IC50: 8.2, 56, 160 nM, and 190 nM, respectively). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
