220904-83-6
220904-83-6
Chemical Structure
GW 5074
- CAS No.: 220904-83-6
- Formula:C15H8Br2INO2
- Molecular Weight:520.94
IUPAC Name: (Z)-3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one
InChIKey: LMXYVLFTZRPNRV-KMKOMSMNSA-N
SMILES: O=C1NC2=C(/C1=C/C3=CC(Br)=C(C(Br)=C3)O)C=C(C=C2)I
Biological Activity: GW 5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, and has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms[1][2].
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GW 5074 | 99.13% | GW 5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, and has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms. | ||||||||||||||||||||
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GW 5074 (Standard) | ≥98% | GW 5074 (Standard) is the analytical standard of GW 5074 (HY-10542). This product is intended for research and analytical applications. GW 5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, and has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.87
HY-109574Raf inhibitor 2 -
Similarity Score 0.82
HY-130258LC3-mHTT-IN-AN1 -
Similarity Score 0.79
HY-175665LC3 liagnd-2 -
Similarity Score 0.72
HY-112464PKR Inhibitor, negative control -
Similarity Score 0.66
HY-21290SU-4942 -
Similarity Score 0.65
HY-124330Tripolin A -
Similarity Score 0.64
HY-101246RPI-1 -
Similarity Score 0.64
HY-21293SU5201 -
Similarity Score 0.63
HY-21289SU5205 -
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References
- [1]. Chin PC, et al. The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. J Neurochem, 2004, 90(3), 595-608. [Content Brief]
- [2]. Lei Y, et al. The Raf-1 inhibitor GW5074 and NSC 34521 suppress sidestream smoke-induced airway hyperresponsiveness in mice. Respir Res, 2008, 9(1), 71. [Content Brief]
