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  3. LC3-mHTT-IN-AN1

LC3-mHTT-IN-AN1 

Cat. No.: HY-130258 Purity: 97.14%
Handling Instructions

LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.

For research use only. We do not sell to patients.

LC3-mHTT-IN-AN1 Chemical Structure

LC3-mHTT-IN-AN1 Chemical Structure

CAS No. : 486443-73-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 341 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 341 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 310 In-stock
Estimated Time of Arrival: December 31
10 mg USD 460 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1400 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2000 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1].

IC50 & Target

mHTT-LC3 Linker Compound

In Vitro

LC3-mHTT-IN-AN1 (10, 50, 100, and 300 nM) reduces the levels of mHTT in an allele-selective manner in cultured HD mouse neurons[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

411.04

Formula

C15H9Br2NO3

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (304.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4329 mL 12.1643 mL 24.3285 mL
5 mM 0.4866 mL 2.4329 mL 4.8657 mL
10 mM 0.2433 mL 1.2164 mL 2.4329 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.06 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 97.14%

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Product Name:
LC3-mHTT-IN-AN1
Cat. No.:
HY-130258
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