486443-73-6
486443-73-6
Chemical Structure
LC3-mHTT-IN-AN1
- CAS No.: 486443-73-6
- Formula:C15H9Br2NO3
- Molecular Weight:411.04
IUPAC Name: (Z)-5-bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one
InChIKey: GPKLWRHHVIBYEO-KMKOMSMNSA-N
SMILES: BrC1=CC=C(C/2=C1)NC(C2=C/C3=CC(Br)=C(C(O)=C3)O)=O
Biological Activity: LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
LC3-mHTT-IN-AN1 | 98.86% | LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
