Raf inhibitor 2
Based on 1 publication(s) in Google Scholar
Raf inhibitor 2 is a potent raf kinase (IC50<1.0 μM) inhibitor, compound 32, extracted from patent EP1003721B1. Raf inhibitor 2 can be used for cancer research.
For research use only. We do not sell to patients.
- Purity: 98.11%
- CAS No.: 220904-99-4
- Formula: C15H8Br2ClNO2
- Molecular Weight:429.49
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Raf inhibitor 2
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
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| H4 | IC50 |
15 μM
Compound: 16k
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Inhibition of gamma secretase in human H4 cells expressing APP695 assessed as inhibition of Abeta42 production after 20 to 24 hrs by liquid phase electrochemiluminescence assay
Inhibition of gamma secretase in human H4 cells expressing APP695 assessed as inhibition of Abeta42 production after 20 to 24 hrs by liquid phase electrochemiluminescence assay
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[PMID: 23107479] |
Chemical Information
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CAS No. 220904-99-4
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Appearance Solid
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Molecular Weight 429.49
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Formula C15H8Br2ClNO2
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Color White to yellow
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SMILES
O=C1NC2=C(C=C(Cl)C=C2)/C1=C/C3=CC(Br)=C(O)C(Br)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576
Solvent & Solubility
DMSO : 100 mg/mL (232.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.3283 mL | 11.6417 mL | 23.2834 mL | 58.2086 mL |
| 5 mM | 0.4657 mL | 2.3283 mL | 4.6567 mL | 11.6417 mL | |
| 10 mM | 0.2328 mL | 1.1642 mL | 2.3283 mL | 5.8209 mL | |
| 15 mM | 0.1552 mL | 0.7761 mL | 1.5522 mL | 3.8806 mL | |
| 20 mM | 0.1164 mL | 0.5821 mL | 1.1642 mL | 2.9104 mL | |
| 25 mM | 0.0931 mL | 0.4657 mL | 0.9313 mL | 2.3283 mL | |
| 30 mM | 0.0776 mL | 0.3881 mL | 0.7761 mL | 1.9403 mL | |
| 40 mM | 0.0582 mL | 0.2910 mL | 0.5821 mL | 1.4552 mL | |
| 50 mM | 0.0466 mL | 0.2328 mL | 0.4657 mL | 1.1642 mL | |
| 60 mM | 0.0388 mL | 0.1940 mL | 0.3881 mL | 0.9701 mL | |
| 80 mM | 0.0291 mL | 0.1455 mL | 0.2910 mL | 0.7276 mL | |
| 100 mM | 0.0233 mL | 0.1164 mL | 0.2328 mL | 0.5821 mL |
Raf inhibitor 2 Related Classifications
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