2. Anti-infection Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Bacterial Toll-like Receptor (TLR) NO Synthase C-type Lectin-like Receptors (CTLRs) Reactive Oxygen Species (ROS)
  4. Curdlan

Curdlan is a polysaccharide found in bacteria, consisting of a glucose homopolymer with β-1,3-glycosidic linkages. Curdlan can be recognized by Dectin-1 (a C-type lectin receptor), inducing immune responses in tissue mast cells and enhancing dendritic cell effects in tumor immunity. Curdlan holds potential for research in cancer and immune-inflammatory diseases.

For research use only. We do not sell to patients.

CAS No. : 54724-00-4

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Customer Review

Based on 2 publication(s) in Google Scholar

Curdlan Related Antibodies

Top Publications Citing Use of Products
In Vivo Efficacy Study
Histological Imaging/Staining
Flow Cytometry

    Curdlan purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 28.

    Curdlan (3 mg; i.p.; once a week for twice) developed robust polyarthritis in BALB/c mice within four weeks.

    Curdlan purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 28.

    Curdlan (3 mg; i.p.; once a week for twice) induced inflammation in BALB/c-ZAP70W163C mice.

    Curdlan purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 28.

    Curdlan (3 mg; i.p.; once a week for twice) exacerbated inflammatory infiltrates and cartilage degradation in SKG mice.

    Curdlan purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 28.

    Curdlan (3 mg; i.p.; once a week for twice) significantly increased the proportion of CD45+ immune cells in the joints of SKG mice.

    Curdlan purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 28.

    Curdlan (3 mg; i.p.; once a week for twice) significantly increased proportions of CD3+ T cells and CD11b+ myeloid cells in the soft tissues of SKG mouse ankle joints.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Curdlan is a polysaccharide found in bacteria, consisting of a glucose homopolymer with β-1,3-glycosidic linkages[1]. Curdlan can be recognized by Dectin-1 (a C-type lectin receptor), inducing immune responses in tissue mast cells and enhancing dendritic cell effects in tumor immunity. Curdlan holds potential for research in cancer and immune-inflammatory diseases[1][2][3].

    In Vitro

    Curdlan (10, 30, 100 μg/mL, 48 hours) activates dendritic cells by upregulating the expression of Dectin-1 and TLR4[2].
    Curdlan (10, 30, 100 μg/mL, 24 hours) activates the immune effects of dendritic cells by regulating the cell cycle, enhancing dendritic cell migration ability, and increasing NO production[2].
    Curdlan (50 μg/mL, 1 hour) induces tissue mast cells to modulate immune responses via the Dectin-1 receptor, stimulating their migration, synthesis of pro-inflammatory mediators, and production of ROS[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Curdlan Related Antibodies

    Western Blot Analysis[2]

    Cell Line: LPS-induced mouse dendritic cells (BM cells from C57BL/6 mice)
    Concentration: 10 μg/mL, 30 μg/mL, 100 μg/mL
    Incubation Time: 48 hours
    Result: Increased the protein expression of Dectin-1 and TLR4.

    Cell Invasion Assay[2]

    Cell Line: LPS-induced mouse dendritic cells (BM cells from C57BL/6 mice)
    Concentration: 10 μg/mL, 30 μg/mL, 100 μg/mL
    Incubation Time: 24 hours
    Result: Significantly enhanced the migration ability of dendritic cells.

    Cell Cycle Analysis[2]

    Cell Line: LPS-induced mouse dendritic cells (BM cells from C57BL/6 mice)
    Concentration: 10 μg/mL, 30 μg/mL, 100 μg/mL
    Incubation Time: 24 hours
    Result: Increased the proportion of dendritic cells in the G0/G1 phase.
    In Vivo

    Curdlan (10 mg/kg, i.p., every two days for 14 days) significantly enhances the antitumor immune response of dendritic cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: B16F10 melanoma model in C57BL/6 mice (B16F10 cells were implanted subcutaneously into syngeneic mice)[2]
    Dosage: 10 mg/kg or 100 μg/mL
    Administration: Method 1: Intraperitoneal injection (i.p.), every two days for 14 days (accompanied by subcutaneous injection of dendritic cells once a day for 14 days)
    Method 2: Pre-treated dendritic cells with curdlan (100 μg/mL) in vitro for 48 hours, then injected the dendritic cells subcutaneously into mice once a day for a total of 14 days.
    Note: B dendritic cells were activated by 16F10 melanoma cell lysate.
    Result: Enhanced the antitumor immune response of dendritic cells.
    Clinical Trial
    Formula

    (C6H10O5)n
    CAS No.
    Appearance

    Solid

    Color

    White to yellow

    SMILES

    OC[C@H]1O[C@@H](C)[C@H](O)C(OC)[C@@H]1O.[n]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 10 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    0.1 M NaOH : 1 mg/mL (ultrasonic and adjust pH to 12 with NaOH)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 1 mg/mL; Clear solution

      This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 1 mg/mL; Clear solution

      This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
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    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 98.5%

    SDS (252 KB)

    COA (248 KB)

    Handling Instructions (2659 KB)
    References
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    Curdlan Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Curdlan54724-00-4BacterialToll-like Receptor (TLR)NO SynthaseC-type Lectin-like Receptors (CTLRs)Reactive Oxygen Species (ROS)Nitric oxide synthasesNOStissue mast cellsdendritic cellstumor immunityInhibitorinhibitorinhibit

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