Lentinan
Based on 8 publication(s) in Google Scholar
Lentinan is an orally active biocompatible multifunctional polysaccharide with biological activities such as anti-inflammatory, antioxidant, immune regulation, anti-tumor, hypoglycemic, and lipid-lowering[1][4].
For research use only. We do not sell to patients.
- CAS No.: 37339-90-5
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Lentinan
More- Int J Biol Macromol. 2025 Sep;322(Pt 3):146900. [Abstract]
- Int J Biol Macromol. 2025 Sep;321(Pt 4):146457. [Abstract]
- Int J Biol Macromol. 2025 Feb 5:140717. [Abstract]
- Biomed Pharmacother. 2020 Nov;131:110541. [Abstract]
- Cell Death Discov. 2025 Mar 15;11(1):103. [Abstract]
- NPJ Vaccines. 2026 Jan 30;11(1):60. [Abstract]
- PLoS Negl Trop Dis. 2020 Sep 25;14(9):e0008632. [Abstract]
- Research Square Preprint. 2024 Apr 23.
Customer Validation & Images
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In Vivo Efficacy Study
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IHC
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Cell Proliferation/Viability Assay
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Flow Cytometry
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Cell Migration/Invasion Assay
Biological Activity
Lentinan (100 μg/mL, 6 h) inhibits oxidative stress and alleviates LPS induced inflammation and apoptosis in bovine mammary epithelial cells by activating the Nrf2 signaling pathway[1]. Lentinan (0-200 μM, 24 h) reduces proliferation, migration, invasion, and cell stemness of lung adenocarcinoma cell lines H1299 and H460, and promotes cell apoptosis[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:lipopolysaccharide (LPS)-induced injury of bovine mammary epithelial cells (BMECs)
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Concentration:100 μg/mL
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Incubation Time:6 h
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Result:Increased the gene expression of CAT and HO-1.
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Cell Line:Human LUAD cell lines H1299 and H460
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Concentration:0-200 μM
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Incubation Time:24 h
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Result:Reduced cell viability and proliferation ability of H1299 and H460
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Virus-infected ICR mice[2].
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Dosage:5, 10, 20 mg/kg
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Administration:Oral gavage (p.o.); once a day; 5 days
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Result:Had a high degree of protection in mice against infection with influenza A virus, delayed the emergence of clinical manifestations, improved the survival rate of mice, significantly prolonged the middle survival days, attenuated the weight loss, and reduced the lung coefficient of mice.
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Animal Model:Male BALB/c mice model of burn plus P. aeruginosa infection[3].
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Dosage:40, 100, 250 mg/kg
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Administration:Intraperitoneal injection (i.p.); once a day; 5 days
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Result:Reduced lipopolysaccharide induced IL-10 production and weakened LPS stimulated Erk-FoxO1 activation in Tregs isolated from burned mice.
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Animal Model:Male BALB/c nude mice with H1299 cells[4].
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Dosage:100 μM, 200 μL
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Administration:Subcutaneous injection (s.c.); once a day
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Result:Reduced tumor volume, weight, and Ki-67 expression levels.
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Animal Model:Antibiotic-driven gut microbial dysbiosis mice[5].
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Dosage:200 mg/kg
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Administration:Oral gavage (p.o.); once a day; 14 days
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Result:Reversed the dysbiosis and increased beneficial microbiota, including S24-7, Lactobacillus, Oscillospira, Ruminococcus and Allobaculum.
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Animal Model:Male db/db mice[6].
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Dosage:10 mg/kg
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Administration:Oral gavage (p.o.); once a day; 12 weeks
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Result:Restored diastolic function and alleviated myocardial remodeling in diabetic cardiomyopathy (DCM).
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 37339-90-5
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Appearance Solid
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Color Light yellow to brown
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SMILES
[Lentinan]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (8)
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Journal Impact Factor
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Most Recent
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Int J Biol Macromol
Lentinan rewrites extracellular matrix homeostasis by activating mitophagy via mTOR/PINK1/Parkin pathway in cartilage to alleviating osteoarthritis. [Abstract]2025 Sep;322(Pt 3):146900. PMID: 40819752 -
Int J Biol Macromol
Lentinan attenuates histone deacetylation of SOCS1 promoter to remodel autophagy via JAK2/STAT3 pathway for the prevention of intervertebral disc degeneration. [Abstract]2025 Sep;321(Pt 4):146457. PMID: 40749910 -
Int J Biol Macromol
Lentinan enhances microbiota-derived isoursodeoxycholic acid levels to alleviate hepatic ischemia-reperfusion injury in mice. [Abstract]2025 Feb 5:140717. PMID: 39920949 -
Biomed Pharmacother
Water extract of sporoderm-broken spores of Ganoderma lucidum enhanced pd-l1 antibody efficiency through downregulation and relieved complications of pd-l1 monoclonal antibody. [Abstract]2020 Nov;131:110541. PMID: 33152901 -
Cell Death Discov
Lentinan suppresses the progression of neuroblastoma by inhibiting FOS-mediated transcription activation of VRK1 to stabilize p53 protein. [Abstract]2025 Mar 15;11(1):103. PMID: 40089488
Lentinan purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Mar 15;11(1):103. [Abstract]
Tumor-bearing model mice was injected with PBS or Lentinan (LNT) (100, 200 mg/kg, i.p.). Tumors were resected for size measurement on 28th day after injection.
Lentinan purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Mar 15;11(1):103. [Abstract]
The positive expression of proliferation marker (ki67) in tumor tissues isolated from two groups of tumors was detected by IHC treated with Lentinan (LNT) (100, 200 mg/kg, i.p.).
Lentinan purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Mar 15;11(1):103. [Abstract]
The viability of NB cells was measured by CCK-8 assay after being treated with the increased dose of Lentinan (LNT) (0, 10, 20, 40 μg/mL).
Lentinan purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Mar 15;11(1):103. [Abstract]
Cell cycle progress was monitored by flow cytometry in NB cells treated with different doses of Lentinan (LNT) (0, 10, 20, 40 μg/mL).
Lentinan purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Mar 15;11(1):103. [Abstract]
The migrating and invasive abilities of NB cells were detected by Transwell assays after being treated with four different doses of Lentinan (LNT) (0, 10, 20, 40 μg/mL).
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NPJ Vaccines
Intranasal S-2P and lentinan formulation confers broad protection against SARS-CoV-2 VOCs via IFN-γ-dominant mechanisms. [Abstract]2026 Jan 30;11(1):60. PMID: 41611712 -
PLoS Negl Trop Dis
Lentinan improved the efficacy of vaccine against Trichinella spiralis in an NLRP3 dependent manner. [Abstract]2020 Sep 25;14(9):e0008632. PMID: 32976511 -
Solvent & Solubility
H2O : 50 mg/mL (Need ultrasonic)
0.1 M NaOH : 33.33 mg/mL (ultrasonic and adjust pH to 9 with NaOH)
Acetone : < 1 mg/mL (insoluble)
Purity & Documentation
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Data Sheet (298 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Meng M, et al. Lentinan inhibits oxidative stress and alleviates LPS-induced inflammation and apoptosis of BMECs by activating the Nrf2 signaling pathway. Int J Biol Macromol. 2022 Dec 1;222(Pt B):2375-2391. [Content Brief]
[2]. Cui H, et al. Anti-Influenza Effect and Mechanisms of Lentinan in an ICR Mouse Model. Front Cell Infect Microbiol. 2022 May 20;12:892864. [Content Brief]
[3]. Wang SX, et al. Lentinan ameliorates burn sepsis by attenuating CD4+ CD25+ Tregs. Burns. 2016 Nov;42(7):1513-1521. [Content Brief]
[4]. Chen Q, et al. Upregulation of miR-216a-5p by Lentinan Targeted Inhibition of JAK2/STAT3 Signaling Pathway to Reduce Lung Adenocarcinoma Cell Stemness, Promote Apoptosis, and Slow Down the Lung Adenocarcinoma Mechanisms. Front Oncol. 2021 Nov 25;11:778096. [Content Brief]
[5]. Ji X, et al. Lentinan improves intestinal inflammation and gut dysbiosis in antibiotics-induced mice. Sci Rep. 2022 Nov 15;12(1):19609. [Content Brief]
[6]. Hu S, et al. Lentinan alleviates diabetic cardiomyopathy by suppressing CAV1/SDHA-regulated mitochondrial dysfunction. Biomed Pharmacother. 2023 Nov;167:115645. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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