1. Metabolic Enzyme/Protease
  2. Glucosidase
  3. Fucoidan

Fucoidan 

Cat. No.: HY-132179
Handling Instructions

Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities.

For research use only. We do not sell to patients.

Fucoidan Chemical Structure

Fucoidan Chemical Structure

CAS No. : 9072-19-9

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Description

Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities[1].

In Vitro

Fucoidan is a biologically active polysaccharide found in great abundance in brown marine algae[1].
Fucoidan extracted from A. nodosum is a more potent inhibitor of α-glucosidase, with an IC50 ranging from 0.013 to 0.047 mg/mL, than the inhibition by Fucoidan extracted from F. vesiculosus (IC50=0.049 mg/mL). Fucoidan extracted from F. vesiculosus does not inhibit α-amylase activity, while Fucoidan from A. nodosum decreases α-amylase activity by 7-100% at 5 mg/mL depending upon the algae harvest period. Fucoidan from A. nodosum inhibits α-amylase with an IC50 of 0.12-4.64 mg/mL[1].
Fucoidan is a fucose-rich sulfated polysaccharide typically found in the cell wall of marine algae but also recently isolated from terrestrial sources. Fucoidan exhibits an attractive therapeutic potential against a wide array of metabolic diseases associated with oxidative stress[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fucoidan (single injection of 25 mg/kg/body) does not inhibit tumor cell proliferation, while three-time injections of 10 mg/kg/body weight significantly reduces tumor growth and metastasis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[3]
Dosage: 10-400 mg/kg
Administration: Intraperitoneal injection; followed by total-body irradiation
Result: The mice injected with 100 mg/kg showed the best survival rate at 30 days post-irradiation.
CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O : 62.5 mg/mL (Need ultrasonic)

References
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Fucoidan
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