2. Metabolic Enzyme/Protease
  3. Glycosidase
  4. Fucoidan

Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities.

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CAS No. : 9072-19-9

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Based on 6 publication(s) in Google Scholar

Fucoidan Related Antibodies

Top Publications Citing Use of Products

    Fucoidan purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Feb 15;22(1):155.  [Abstract]

    mRECs were treated with with Fucoidan (FO, 60 μg/ml) for an additional 4 h, and then treated with Ang II (100 nM) for 24 h. 2′,7′-Dichlorodihydrofluorescein diacetate (DCFH-DA) staining of ROS production in cells (left), the quantification of ROS intensity.

    Fucoidan purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Feb 15;22(1):155.  [Abstract]

    mRECs were treated with with Fucoidan (FO, 60 μg/ml) for an additional 4 h, and then treated with Ang II (100 nM) for 24 h. qPCR analyses of Sirt1, Nlrp3 and Il1b mRNA in mRECs.

    Fucoidan purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Feb 15;22(1):155.  [Abstract]

    mRECs were treated with with Fucoidan (FO, 60 μg/ml) for an additional 4 h, and then treated with Ang II (100 nM) for 24 h. The expression of SIRT1, NLRP3, IL-1β and IL-1β p17 protein levels.

    Fucoidan purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Feb 15;22(1):155.  [Abstract]

    We gave the mice with Fucoidan (300 mg/kg/day) one day before Ang II infusion. H&E staining showed that Fucoidan treatment decreased Ang II-induced central retinal thickening.

    Fucoidan purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Feb 15;22(1):155.  [Abstract]

    Mice were treated with Fucoidan (300 mg/kg/day) one day before Ang II perfusion, followed by once daily for 3 weeks. Retinal angiography and fundus photography were performed.

    • Biological Activity

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    Description

    Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities[1].

    In Vitro

    Fucoidan is a biologically active polysaccharide found in great abundance in brown marine algae[1].
    Fucoidan extracted from A. nodosum is a more potent inhibitor of α-glucosidase, with an IC50 ranging from 0.013 to 0.047 mg/mL, than the inhibition by Fucoidan extracted from F. vesiculosus (IC50=0.049 mg/mL). Fucoidan extracted from F. vesiculosus does not inhibit α-amylase activity, while Fucoidan from A. nodosum decreases α-amylase activity by 7-100% at 5 mg/mL depending upon the algae harvest period. Fucoidan from A. nodosum inhibits α-amylase with an IC50 of 0.12-4.64 mg/mL[1].
    Fucoidan is a fucose-rich sulfated polysaccharide typically found in the cell wall of marine algae but also recently isolated from terrestrial sources. Fucoidan exhibits an attractive therapeutic potential against a wide array of metabolic diseases associated with oxidative stress[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Fucoidan Related Antibodies
    In Vivo

    Fucoidan (single injection of 25 mg/kg/body) does not inhibit tumor cell proliferation, while three-time injections of 10 mg/kg/body weight significantly reduces tumor growth and metastasis[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Mice[3]
    Dosage: 10-400 mg/kg
    Administration: Intraperitoneal injection; followed by total-body irradiation
    Result: The mice injected with 100 mg/kg showed the best survival rate at 30 days post-irradiation.
    Clinical Trial
    CAS No.
    Appearance

    Solid

    Color

    Off-white to light brown

    SMILES

    [Fucoidan]
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 5 mg/mL (ultrasonic and warming and heat to 60°C)

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 5 mg/mL; Clear solution; Need ultrasonic and warming and heat to 60°C

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    Working solution concentration: mg/mL
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 98.62%

    SDS (393 KB)

    COA (243 KB)

    Handling Instructions (2659 KB)
    References
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    Fucoidan Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Fucoidan9072-19-9GlycosidaseType 2diabetespolysaccharideα-amylaseα-glucosidase. AntioxidantantisteatoticanticoagulantanticancerInhibitorinhibitorinhibit

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