Fucoidan
Based on 9 publication(s) in Google Scholar
Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 9072-19-9
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Fucoidan
More- Adv Mater. 2026 Feb;38(11):e11078. [Abstract]
- Nat Biomed Eng. 2026 Jun 3. [Abstract]
- Adv Funct Mater. 2025 Nov 4.
- J Transl Med. 2024 Feb 15;22(1):155. [Abstract]
- J Colloid Interface Sci. 2025 Jun 30;700(Pt 1):138290. [Abstract]
- Int J Biol Macromol. 2026 May:361:152014. [Abstract]
- CNS Neurosci Ther. 2024 Aug;30(8):e14903. [Abstract]
- Mar Drugs. 2026 Jul 2;24(7):232.
- J Biochem Mol Toxicol. 2025 Nov;39(11):e70574. [Abstract]
Customer Validation & Images
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Cell Imaging/Staining
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RT-PCR
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WB
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Histological Imaging/Staining
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Histological Imaging/Staining
Biological Activity
Description
In Vitro
Fucoidan is a biologically active polysaccharide found in great abundance in brown marine algae[1].
Fucoidan extracted from A. nodosum is a more potent inhibitor of α-glucosidase, with an IC50 ranging from 0.013 to 0.047 mg/mL, than the inhibition by Fucoidan extracted from F. vesiculosus (IC50=0.049 mg/mL). Fucoidan extracted from F. vesiculosus does not inhibit α-amylase activity, while Fucoidan from A. nodosum decreases α-amylase activity by 7-100% at 5 mg/mL depending upon the algae harvest period. Fucoidan from A. nodosum inhibits α-amylase with an IC50 of 0.12-4.64 mg/mL[1].
Fucoidan is a fucose-rich sulfated polysaccharide typically found in the cell wall of marine algae but also recently isolated from terrestrial sources. Fucoidan exhibits an attractive therapeutic potential against a wide array of metabolic diseases associated with oxidative stress[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice[3]
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Dosage:10-400 mg/kg
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Administration:Intraperitoneal injection; followed by total-body irradiation
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Result:The mice injected with 100 mg/kg showed the best survival rate at 30 days post-irradiation.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 9072-19-9
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Appearance Solid
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Color Off-white to light brown
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SMILES
[Fucoidan]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (9)
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Journal Impact Factor
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Most Recent
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Adv Mater
Fluoropolymer-Mediated Delivery of a Dual TSHR/IGF1R-Targeting CRISPR-Cas9 System for Localized Therapy in Thyroid-Associated Ophthalmopathy. [Abstract]2026 Feb;38(11):e11078. PMID: 41486850 -
Nat Biomed Eng
Modular nucleic acid-based construct for delivery of immunostimulatory agonists and oncogene-silencing oligonucleotides in tumours. [Abstract]2026 Jun 3. PMID: 42236980 -
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J Transl Med
Fucoidan modulates SIRT1 and NLRP3 to alleviate hypertensive retinopathy: in vivo and in vitro insights. [Abstract]2024 Feb 15;22(1):155. PMID: 38360728
Fucoidan purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Feb 15;22(1):155. [Abstract]
mRECs were treated with with Fucoidan (FO, 60 μg/ml) for an additional 4 h, and then treated with Ang II (100 nM) for 24 h. 2′,7′-Dichlorodihydrofluorescein diacetate (DCFH-DA) staining of ROS production in cells (left), the quantification of ROS intensity.
Fucoidan purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Feb 15;22(1):155. [Abstract]
mRECs were treated with with Fucoidan (FO, 60 μg/ml) for an additional 4 h, and then treated with Ang II (100 nM) for 24 h. qPCR analyses of Sirt1, Nlrp3 and Il1b mRNA in mRECs.
Fucoidan purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Feb 15;22(1):155. [Abstract]
mRECs were treated with with Fucoidan (FO, 60 μg/ml) for an additional 4 h, and then treated with Ang II (100 nM) for 24 h. The expression of SIRT1, NLRP3, IL-1β and IL-1β p17 protein levels.
Fucoidan purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Feb 15;22(1):155. [Abstract]
We gave the mice with Fucoidan (300 mg/kg/day) one day before Ang II infusion. H&E staining showed that Fucoidan treatment decreased Ang II-induced central retinal thickening.
Fucoidan purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Feb 15;22(1):155. [Abstract]
Mice were treated with Fucoidan (300 mg/kg/day) one day before Ang II perfusion, followed by once daily for 3 weeks. Retinal angiography and fundus photography were performed.
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J Colloid Interface Sci
Platelet-hitchhiking triiodothyronine nanoparticles for enhanced therapy of cerebral ischemia-reperfusion injury. [Abstract]2025 Jun 30;700(Pt 1):138290. PMID: 40618479 -
Int J Biol Macromol
A vascular graft with hydrogen-bonded network structure for leak-free puncture resistance, spatiotemporal anticoagulation, and rapid endothelialization via fucoidan-heparin functionalization. [Abstract]2026 May:361:152014. PMID: 41997327 -
CNS Neurosci Ther
Fucoidan improving spinal cord injury recovery: Modulating microenvironment and promoting remyelination. [Abstract]2024 Aug;30(8):e14903. PMID: 39139089 -
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J Biochem Mol Toxicol
Fucoidan Prevents Paraquat-Induced Hepatic Injury by Attenuating Oxidative and Inflammatory Stress: An In Vivo and In Vitro Approach. [Abstract]2025 Nov;39(11):e70574. PMID: 41158090
Solvent & Solubility
In Vitro:
H2O : 5 mg/mL (ultrasonic and warming and heat to 60°C)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 5 mg/mL; Clear solution; Need ultrasonic and warming and heat to 60°C
Purity & Documentation
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Data Sheet (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Kyung-Tae Kim, et al. Alpha-amylase and alpha-glucosidase inhibition is differentially modulated by fucoidan obtained from Fucus vesiculosus and Ascophyllum nodosum.Phytochemistry. 2014 Feb;98:27-33. [Content Brief]
[2]. Zeinab El Rashed, et al. Antioxidant and Antisteatotic Activities of Fucoidan Fractions from Marine and Terrestrial Sources. Molecules. 2021 Jul 24;26(15):4467. [Content Brief]
[3]. Farzaneh Atashrazm, et al. Fucoidan and cancer: a multifunctional molecule with anti-tumor potential. Mar Drugs. 2015 Apr 14;13(4):2327-46. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fucoidan Related Classifications
HY-132179 Related Classifications
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