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  4. Zymosan A

Zymosan A  (Synonyms: Zymosan A from Saccharomyces cerevisiae)

Cat. No.: HY-W250113
COA Handling Instructions

Zymosan A (Zymosan A from Saccharomyces cerevisiae) is a TLR2 agonist, that targeting TLRs can prevent and suppress IR-induced intestinal injury. Zymosan A exhibits a significant radioprotective effect, and protects IR-induced intestinal injury in mice. Zymosan A promotes the regeneration of intestinal stem cells (ISCs), after IR injury.

For research use only. We do not sell to patients.

Zymosan A Chemical Structure

Zymosan A Chemical Structure

CAS No. : 58856-93-2

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Based on 1 publication(s) in Google Scholar

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Description

Zymosan A (Zymosan A from Saccharomyces cerevisiae) is a TLR2 agonist, that targeting TLRs can prevent and suppress IR-induced intestinal injury. Zymosan A exhibits a significant radioprotective effect, and protects IR-induced intestinal injury in mice. Zymosan A promotes the regeneration of intestinal stem cells (ISCs), after IR injury[1].

In Vivo

Zymosan A can be used in animal modeling to establish a mouse peritonitis model.

Zymosan A (25.0 mg/kg; IP at 12 and 2 h before IR) mitigates IR-induced intestinal injury in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 20.0 Gy abdominal irradiation (ABI) model in mice[1]
Dosage: 25.0 mg/kg, dissolved in NS
Administration: IP; injection at 12 and 2 h before IR
Result: Significantly reduced the degree of bleeding and edema in the intestinal tissue.
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

[Zymosan A]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 1.94 mg/mL (ultrasonic and warming and adjust pH to 4 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Zymosan A
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HY-W250113
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