23491-48-7
Chemical Structure
SIRT6-IN-6
- CAS No.: 23491-48-7
- Formula:C11H16N4O2
- Molecular Weight:236.28
IUPAC Name: 5-(4-methylpiperazin-1-yl)-2-nitroaniline
InChIKey: MWLBMGPQZJDFKZ-UHFFFAOYSA-N
SMILES: O=N(=O)C1=CC=C(C=C1N)N2CCN(C)CC2
Biological Activity: SIRT6-IN-6 (compound 6d) is a potent and selective SIRT6 inhibitor with an IC50 of 4.93 μM and a Ki of ~10 μM. SIRT6-IN-6 shows selectivity against other members of the HDAC family (SIRT1-3 and HDAC1-11). SIRT6-IN-6 significantly increases the level of glucose transporter GLUT-1, thereby reducing blood glucose in a mouse model of type 2 diabetes. SIRT6-IN-6 can be used for type 2 diabetes research[1].
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SIRT6-IN-6 | 98.59% | SIRT6-IN-6 (compound 6d) is a potent and selective SIRT6 inhibitor with an IC50 of 4.93 μM and a Ki of ~10 μM. SIRT6-IN-6 shows selectivity against other members of the HDAC family (SIRT1-3 and HDAC1-11). SIRT6-IN-6 significantly increases the level of glucose transporter GLUT-1, thereby reducing blood glucose in a mouse model of type 2 diabetes. SIRT6-IN-6 can be used for type 2 diabetes research. | ||||||||||||||||||||
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Keywords
