1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin

SIRT-IN-2 

Cat. No.: HY-16616
Handling Instructions

SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively.

For research use only. We do not sell to patients.

SIRT-IN-2 Chemical Structure

SIRT-IN-2 Chemical Structure

CAS No. : 1431411-66-3

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  • References

Description

SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively.

IC50 & Target

SIRT1

4 nM (IC50)

SIRT2

1 nM (IC50)

SIRT3

7 nM (IC50)

In Vitro

SIRT-IN-2 (compound 31) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 4, 4, 7 μM, respectively. SIRT-IN-2 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 Å), occupying the nicotinamide C-pocket and acetyl lysine substrate channel[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6076 mL 13.0381 mL 26.0763 mL
5 mM 0.5215 mL 2.6076 mL 5.2153 mL
10 mM 0.2608 mL 1.3038 mL 2.6076 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

383.49

Formula

C₁₅H₂₁N₅O₃S₂

CAS No.

1431411-66-3

SMILES

NC(C1=CC2=NC=NC(N3CCC(CCNS(C)(=O)=O)CC3)=C2S1)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
SIRT-IN-2
Cat. No.:
HY-16616
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SIRT-IN-2

Cat. No.: HY-16616