1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Gamma-glutamylcysteine

Gamma-glutamylcysteine (Synonyms: γ-Glutamylcysteine)

Cat. No.: HY-113402
Handling Instructions

Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels.

For research use only. We do not sell to patients.

Gamma-glutamylcysteine Chemical Structure

Gamma-glutamylcysteine Chemical Structure

CAS No. : 636-58-8

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Description

Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Co-treatment of Aβ40 oligomers with Gamma-glutamylcysteine (γ-Glutamylcysteine; GGC) at 200 μM increased the activity of the antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) and leads to significant increases in the levels of the total antioxidant capacity (TAC) and GSH and reduces the GSSG/GSH ratio. Gamma-glutamylcysteine also upregulates the level of the anti-inflammatory cytokine IL-10 and reduced the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

250.27

Formula

C₈H₁₄N₂O₅S

CAS No.
SMILES

SC[[email protected]@H](C(O)=O)NC(CC[[email protected]](N)C(O)=O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Gamma-glutamylcysteineγ-GlutamylcysteineEndogenous MetabolitedipeptideGSHcysteineglutamicacidGPxantioxidantanti-inflammatoryInhibitorinhibitorinhibit

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Gamma-glutamylcysteine
Cat. No.:
HY-113402
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