1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Gamma-glutamylcysteine

Gamma-glutamylcysteine  (Synonyms: γ-Glutamylcysteine)

Cat. No.: HY-113402 Purity: ≥90.0%
COA Handling Instructions

Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels.

For research use only. We do not sell to patients.

Gamma-glutamylcysteine Chemical Structure

Gamma-glutamylcysteine Chemical Structure

CAS No. : 636-58-8

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25 mg USD 100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 200 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Gamma-glutamylcysteine:

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Description

Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Co-treatment of Aβ40 oligomers with Gamma-glutamylcysteine (γ-Glutamylcysteine; GGC) at 200 μM increased the activity of the antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) and leads to significant increases in the levels of the total antioxidant capacity (TAC) and GSH and reduces the GSSG/GSH ratio. Gamma-glutamylcysteine also upregulates the level of the anti-inflammatory cytokine IL-10 and reduced the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

250.27

Formula

C8H14N2O5S

CAS No.
SMILES

SC[[email protected]@H](C(O)=O)NC(CC[[email protected]](N)C(O)=O)=O

Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (399.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9957 mL 19.9784 mL 39.9568 mL
5 mM 0.7991 mL 3.9957 mL 7.9914 mL
10 mM 0.3996 mL 1.9978 mL 3.9957 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Gamma-glutamylcysteine
Cat. No.:
HY-113402
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