Glutathione oxidized
Based on 9 publication(s) in Google Scholar
Glutathione oxidized (L-Glutathione oxidized) is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes.
For research use only. We do not sell to patients.
- Purity: 98.88%
- CAS No.: 27025-41-8
- Formula: C20H32N6O12S2
- Molecular Weight:612.63
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Publications Citing Use of MedChemExpress (MCE) Glutathione oxidized
More- Adv Sci (Weinh). 2022 Dec;9(34):e2203088. [Abstract]
- Chem Biol Interact. 2024 Dec 31:111368. [Abstract]
- Nanoscale. 2026 Apr 14. [Abstract]
- Invest Ophthalmol Vis Sci. 2025 May 1;66(5):19. [Abstract]
- J Chromatogr A. 2024 Apr 12:1720:464776. [Abstract]
- Microbiol Spectr. 2023 Sep 21;11(5):e0267123. [Abstract]
- PLoS Genet. 2026 Jan 23;22(1):e1012013. [Abstract]
- bioRxiv. 2024 June 12.
- SSRN. 2023 Nov 17.
Customer Validation & Images
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Cell Proliferation/Viability Assay
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IF
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RT-PCR
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IF
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WB
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Increased efflux of Glutathione oxidized leads to glutathione depletion and may weaken the antioxidant defense of sickle erythrocytes[1].
Glutathione oxidized (400 μM) inhibits epithelial sodium channel activity in primary alveolar epithelial T2 cells[2].
Glutathione oxidized will self-assemble to form a gel at high concentrations and should be used as soon as possible and avoid prolonged ultrasonic treatment. Self-assembly will not occur at low concentrations (such as 8 mM).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 27025-41-8
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Appearance Solid
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Molecular Weight 612.63
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Formula C20H32N6O12S2
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Color White to off-white
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Synonyms
L-Glutathione oxidized; GSSG; Oxiglutatione
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Sequence
γGlu-Cys-Gly (Cys dimer)
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Sequence Shortening
γGlu-CG (Cys dimer)
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (9)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
SRSF5-Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host-Directed Target Against Influenza Virus. [Abstract]2022 Dec;9(34):e2203088. PMID: 36257906 -
Chem Biol Interact
Integrated network pharmacology, bioinformatics, and experiment analysis to decipher the molecular mechanism of Salidroside on Gastric cancer via targeting NCOA4-mediated ferritinophagy. [Abstract]2024 Dec 31:111368. PMID: 39746501
Glutathione oxidized purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2024 Dec 31:111368. [Abstract]
DFO (100 μM，24 h) and GSH (2 mM, 24 h) reversed the inhibition of Sal on MGC803 cell viability.
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Nanoscale
Targeting glutamine metabolism combined with a nanoradioenhancer in radioresistant hepatocellular carcinoma. [Abstract]2026 Apr 14. PMID: 41978422 -
Invest Ophthalmol Vis Sci
Regulatory Effects of the Wnt7b/β-Catenin/MMP-2 Signaling Pathway on Scleral Stiffness in Guinea Pigs With Form-Deprivation Myopia. [Abstract]2025 May 1;66(5):19. PMID: 40338179
Glutathione oxidized purchased from MedChemExpress. Usage Cited in: Invest Ophthalmol Vis Sci. 2025 May 1;66(5):19. [Abstract]
The fluorescence intensity of MMP-2 in the HFSFs treated with glutathione oxidized (GLU, 2.48 mg/mL, 24 h) was 2.09 times greater than that in the HFSFs treated with ARP-100 (ARP, 100 μM, 24 h).
Glutathione oxidized purchased from MedChemExpress. Usage Cited in: Invest Ophthalmol Vis Sci. 2025 May 1;66(5):19. [Abstract]
The MMP-2 mRNA level in the HFSFs treated with glutathione oxidized (GLU, 2.48 mg/mL, 24 h) was 2.46 times greater than that in the ARP-100 (ARP, 100 μM, 24 h)-treated HFSFs.
Glutathione oxidized purchased from MedChemExpress. Usage Cited in: Invest Ophthalmol Vis Sci. 2025 May 1;66(5):19. [Abstract]
IF analysis revealed a notable increase in collagen I fluorescence intensity in the HFSFs treated with ARP-100 (ARP, 100 μM, 24 h), whereas a reduction in collagen I fluorescence intensity was found in HFSFs treated with glutathione oxidized (GLU, 2.48 mg/mL, 24 h).
Glutathione oxidized purchased from MedChemExpress. Usage Cited in: Invest Ophthalmol Vis Sci. 2025 May 1;66(5):19. [Abstract]
WB analysis of MMP-2 and collagen I expression in HFSFs following treatment with ARP-100 (ARP, 100 μM), glutathione oxidized (GLU, 2.48 mg/mL), or PBS for 24 hours.
Glutathione oxidized purchased from MedChemExpress. Usage Cited in: Invest Ophthalmol Vis Sci. 2025 May 1;66(5):19. [Abstract]
Compared with guinea pigs receiving periocular injections of vehicle (5 mM, 10 μL on days 1, 4, 7, 10, and 13 over two weeks), those treated with glutathione oxidized (Glu, 20 mg/mL, 10 μL on the same schedule) exhibited a 1.76-fold increase in relative myopia, along with a 1.78-fold increase in axial length (AL).
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J Chromatogr A
Preparation of thiol-free amino acid plasma matrix for quantification of thiol amino acids and their oxidized forms in human plasma by UPLC-MS/MS. [Abstract]2024 Apr 12:1720:464776. PMID: 38432109 -
Microbiol Spectr
Potential quorum-sensing inhibitor of Hafnia alvei H4-theaflavin-3,3´-digallate analyzed by virtual screening and molecular simulation. [Abstract]2023 Sep 21;11(5):e0267123. PMID: 37732782 -
PLoS Genet
A C. elegans model of copper deficiency: Dietary interventions rescue CTR1/CHCA-1 copper transporter mutant phenotype. [Abstract]2026 Jan 23;22(1):e1012013. PMID: 41575937 -
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Solvent & Solubility
H2O : ≥ 200 mg/mL (326.46 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (163.23 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (275 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Nur E, et al. Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes. Biochim Biophys Acta. 2011 Nov;1812(11):1412-7. [Content Brief]
[2]. Downs CA, et al. Oxidized glutathione (GSSG) inhibits epithelial sodium channel activity in primary alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2015 May 1;308(9):L943-52. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.6323 mL | 8.1615 mL | 16.3231 mL | 40.8077 mL |
| 5 mM | 0.3265 mL | 1.6323 mL | 3.2646 mL | 8.1615 mL | |
| 10 mM | 0.1632 mL | 0.8162 mL | 1.6323 mL | 4.0808 mL | |
| 15 mM | 0.1088 mL | 0.5441 mL | 1.0882 mL | 2.7205 mL | |
| 20 mM | 0.0816 mL | 0.4081 mL | 0.8162 mL | 2.0404 mL | |
| 25 mM | 0.0653 mL | 0.3265 mL | 0.6529 mL | 1.6323 mL | |
| 30 mM | 0.0544 mL | 0.2721 mL | 0.5441 mL | 1.3603 mL | |
| 40 mM | 0.0408 mL | 0.2040 mL | 0.4081 mL | 1.0202 mL | |
| 50 mM | 0.0326 mL | 0.1632 mL | 0.3265 mL | 0.8162 mL | |
| 60 mM | 0.0272 mL | 0.1360 mL | 0.2721 mL | 0.6801 mL | |
| 80 mM | 0.0204 mL | 0.1020 mL | 0.2040 mL | 0.5101 mL | |
| 100 mM | 0.0163 mL | 0.0816 mL | 0.1632 mL | 0.4081 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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