2. Disease Areas
  3. Digestive System Disease
  4. Liver Disease
  5. Hepatotoxicity

Hepatotoxicity

Hepatotoxicity refers to liver injury induced by toxic substances, particularly drugs, resulting in histologic changes like necrosis, inflammation, or steatosis, typically identified through clinical suspicion and abnormal liver biochemistry. It involves direct cellular damage and may trigger an immune-mediated inflammatory response. Management focuses on discontinuing the offending agent and providing supportive care.

Hepatotoxicity (3):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W982689
    Fluindarol 6723-40-6
    Fluindarol is a phenylindandione derivative and an orally active anticoagulant. Fluindarol acts as a toxicant that induces organ and tissue haemorrhages and liver parenchymal necrosis in rats. Fluindarol exhibits acute and cumulative preclinical toxicity in rats, rabbits, and dogs, with higher toxicity in female rats than male rats. Fluindarol lacks analgesic action, produces only minor blood pressure effects, and does not alter circulation, respiration, CNS, or cardiac activity. Fluindarol is considered too toxic for clinical use based on preclinical data.
    Fluindarol
  • HY-N7697C
    Chitohexaose hexahydrochloride 127171-88-4
    Chitohexaose hexahydrochloride is a small molecular polysaccharide. Chitohexaose hexahydrochloride inhibits the binding of AgW to TLR4. Chitohexaose hexahydrochloride upregulates IL-10, inhibits LPS-induced upregulation of ROS, induces alternative activation of macrophages/monocytes, and suppresses LPS-induced production of TNF-α, IL-1β and IL-6. Chitohexaose hexahydrochloride reverses the mortality of mice challenged with APAP or LPS. Chitohexaose hexahydrochloride can be used in research related to Acetaminophen (HY-66005)-induced hepatotoxicity and endotoxemia.
    Chitohexaose hexahydrochloride
  • HY-W685358
    D-Tetramethrin 1166-46-7
    D-Tetramethrin is a type I synthetic pyrethroid insecticide and hepatotoxicity inducer. D-Tetramethrin induces oxidative stress in the liver of zebrafish. D-Tetramethrin induces Apoptosis and inflammatory responses. D-Tetramethrin causes severe liver damage in zebrafish. D-Tetramethrin can be used in studies related to hepatotoxicity.
    D-Tetramethrin