2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. DI-1859

DI-1859 is a potent, selective and covalent inhibitor of DCN1. DI-1859 inhibits neddylation of cullin 3 in cells at low nanomolar concentrations. DI-1859 induces a robust increase of NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver damage.

For research use only. We do not sell to patients.

DI-1859 Chemical Structure

DI-1859 Chemical Structure

CAS No. : 2247061-09-0

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5 mg USD 800 In-stock
10 mg USD 1280 In-stock
25 mg USD 2550 In-stock
50 mg USD 4050 In-stock
100 mg USD 6500 In-stock
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Based on 1 publication(s) in Google Scholar

DI-1859 Related Antibodies

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Description

DI-1859 is a potent, selective and covalent inhibitor of DCN1. DI-1859 inhibits neddylation of cullin 3 in cells at low nanomolar concentrations. DI-1859 induces a robust increase of NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver damage[1].

Molecular Weight

555.78

Formula

C30H45N5O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN(C)CC(C(NC[C@H](C1CCCCC1)NC([C@@H](NC(CC)=O)CC(SC2=C3)=NC2=CC=C3C(C)C)=O)=O)=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (179.93 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7993 mL 8.9964 mL 17.9927 mL
5 mM 0.3599 mL 1.7993 mL 3.5985 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.83%

COA (251 KB) HNMR (143 KB) RP-HPLC (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7993 mL 8.9964 mL 17.9927 mL 44.9818 mL
5 mM 0.3599 mL 1.7993 mL 3.5985 mL 8.9964 mL
10 mM 0.1799 mL 0.8996 mL 1.7993 mL 4.4982 mL
15 mM 0.1200 mL 0.5998 mL 1.1995 mL 2.9988 mL
20 mM 0.0900 mL 0.4498 mL 0.8996 mL 2.2491 mL
25 mM 0.0720 mL 0.3599 mL 0.7197 mL 1.7993 mL
30 mM 0.0600 mL 0.2999 mL 0.5998 mL 1.4994 mL
40 mM 0.0450 mL 0.2249 mL 0.4498 mL 1.1245 mL
50 mM 0.0360 mL 0.1799 mL 0.3599 mL 0.8996 mL
60 mM 0.0300 mL 0.1499 mL 0.2999 mL 0.7497 mL
80 mM 0.0225 mL 0.1125 mL 0.2249 mL 0.5623 mL
100 mM 0.0180 mL 0.0900 mL 0.1799 mL 0.4498 mL
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DI-1859 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DI-18592247061-09-0DI1859DI 1859E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseselectiveDCN1cullin 3NRF2CRL3liver damageacetaminophen-inducedInhibitorinhibitorinhibit

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