DI-1859
Based on 1 publication(s) in Google Scholar
DI-1859 is a potent, selective and covalent inhibitor of DCN1. DI-1859 inhibits neddylation of cullin 3 in cells at low nanomolar concentrations. DI-1859 induces a robust increase of NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver damage.
For research use only. We do not sell to patients.
- Purity: 99.62%
- CAS No.: 2247061-09-0
- Formula: C30H45N5O3S
- Molecular Weight:555.78
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) DI-1859
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Biological Activity
Chemical Information
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CAS No. 2247061-09-0
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Appearance Solid
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Molecular Weight 555.78
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Formula C30H45N5O3S
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Color White to off-white
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SMILES
CN(C)CC(C(NC[C@H](C1CCCCC1)NC([C@@H](NC(CC)=O)CC(SC2=C3)=NC2=CC=C3C(C)C)=O)=O)=C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
2026 Apr 29. PMID: 42056084
Solvent & Solubility
DMSO : 100 mg/mL (179.93 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7993 mL | 8.9964 mL | 17.9927 mL | 44.9818 mL |
| 5 mM | 0.3599 mL | 1.7993 mL | 3.5985 mL | 8.9964 mL | |
| 10 mM | 0.1799 mL | 0.8996 mL | 1.7993 mL | 4.4982 mL | |
| 15 mM | 0.1200 mL | 0.5998 mL | 1.1995 mL | 2.9988 mL | |
| 20 mM | 0.0900 mL | 0.4498 mL | 0.8996 mL | 2.2491 mL | |
| 25 mM | 0.0720 mL | 0.3599 mL | 0.7197 mL | 1.7993 mL | |
| 30 mM | 0.0600 mL | 0.2999 mL | 0.5998 mL | 1.4994 mL | |
| 40 mM | 0.0450 mL | 0.2249 mL | 0.4498 mL | 1.1245 mL | |
| 50 mM | 0.0360 mL | 0.1799 mL | 0.3599 mL | 0.8996 mL | |
| 60 mM | 0.0300 mL | 0.1499 mL | 0.2999 mL | 0.7497 mL | |
| 80 mM | 0.0225 mL | 0.1125 mL | 0.2249 mL | 0.5623 mL | |
| 100 mM | 0.0180 mL | 0.0900 mL | 0.1799 mL | 0.4498 mL |
DI-1859 Related Classifications
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