1. Protein Tyrosine Kinase/RTK
  2. Insulin Receptor

Insulin Receptor

Insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of tyrosine kinase receptors. Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis, a functional process that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer. Biochemically, the insulin receptor is encoded by a single gene INSR, from which alternate splicing during transcription results in either IR-A or IR-B isoforms. Downstream post-translational events of either isoform result in the formation of a proteolytically cleaved α and β subunit, which upon combination are ultimately capable of homo or hetero-dimerisation to produce the ≈320 kDa disulfide-linked transmembrane insulin receptor.

Insulin Receptor Related Products (15):

Cat. No. Product Name Effect Purity
  • HY-P0035
    Insulin(human)
    Insulin(human) is a peptide hormone that regulates the level of sugar (glucose) in the blood and that is produced by the beta cells of the pancreatic islets.
  • HY-15656
    LDK378 Inhibitor 99.95%
    LDK378 is a potent and specific ALK inhibitor with an IC50 of 0.2 nM.
  • HY-10191
    Linsitinib Inhibitor 99.90%
    Losmapimod is a dual inhibitor of the IGF-1 receptor and insulin receptor with IC50s of 35 and 75 nM, respectively.
  • HY-P1156
    Insulin(cattle) 98.60%
    Insulin cattle is a kind of polypeptide hormone that regulates glucose metabolism in pancreatic islet B-cells.
  • HY-10200
    BMS-754807 Inhibitor 99.18%
    BMS-754807 is a potent and reversible inhibitor of the insulin-like growth factor 1 receptor (IGF-1R)/insulin receptor family kinases (IR) with IC50 of 1.8 and 1.7 nM, respectively and Ki of <2 nM for both, and also shows potent activities against Met, RON, TrkA, TrkB, AurA, and AurB with IC50 values of 6, 44, 7, 4, 9, and 25 nM, respectively.
  • HY-112819
    Insulin levels modulator Modulator
    Insulin levels modulator could be used to treat diabetes.
  • HY-112720
    AGL-2263 Inhibitor
    AGL-2263 is an insulin receptor (IR) blocker.
  • HY-50866
    NVP-AEW541 Inhibitor 98.76%
    NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 0.15 μM, also inhibits InsR, with IC50 of 0.14 μM.
  • HY-10262
    BMS-536924 Inhibitor 98.73%
    BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM.
  • HY-100037
    NT157 Inhibitor 99.19%
    NT157is a selective inhibitor of IRS-1/2, IC50 values at sub-micromolar doses (ranging from 0.3 to 0.8 μM) .
  • HY-15656A
    LDK378 dihydrochloride Inhibitor 99.86%
    LDK378 2Hcl (Ceritinib) is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively.
  • HY-13020
    GSK1838705A Inhibitor 98.99%
    GSK1838705A is a potent and reversible IGF-IR and the insulin receptor inhibitor with IC50s of 2.0 and 1.6 nM, respectively. It also inhibits ALK with an IC50 of 0.5 nM.
  • HY-100550
    MSDC 0160 >98.0%
    MSDC 0160 act as an insulin sensitizer and a modulator of mitochondrial pyruvate carrier (MPC), a key controller of cellular metabolism that influences mTOR (mammalian target of rapamycin) activation.
  • HY-N0628
    Kaempferitrin Activator
    Kaempferitrin is a natural flavonoid, possesses antinociceptive, anti-inflammatory, anti-diabetic, antitumoral and chemopreventive effects, and activates insulin signaling pathway.
  • HY-15481
    KU14R Antagonist
    KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.