2. Protein Tyrosine Kinase/RTK
  3. Insulin Receptor
  4. Insulin (human)

Insulin (human) is a polypeptide hormone that regulates the level of glucose. Insulin (human) can be used for the diabetes mellitus.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CAS No. : 11061-68-0

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Based on 92 publication(s) in Google Scholar

Other Forms of Insulin (human):

Insulin (human) Related Antibodies

Top Publications Citing Use of Products

92 Publications Citing Use of MCE Insulin (human)

IF
Bio/Physico-chemical Assay
WB

    Insulin (human) purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Nov 4;10(1):361.  [Abstract]

    Tissues from GIST patient samples were digested and resuspended in GIST primary cell culture medium, 1% Anti-Anti, 50 ng/mL SCF, 125 ng/mL EGF, 20 ng/mL bFGF (HY-P7004), 25 ng/mL Hydrocortisone (HY-N0583), and 5 µg/mL Insulin. Olverembatinib inhibited lipid droplet accumulation and lipid uptake in SDH-deficient GIST primary cells and downregulated CD36 in primary SDH-deficient GIST cells..

    Insulin (human) purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Nov 4;10(1):361.  [Abstract]

    Tissues from GIST patient samples were digested and resuspended in GIST primary cell culture medium, 1% Anti-Anti, 50 ng/mL SCF, 125 ng/mL EGF, 20 ng/mL bFGF (HY-P7004), 25 ng/mL Hydrocortisone (HY-N0583), and 5 µg/mL Insulin. Olverembatinib inhibited lipid droplet accumulation and lipid uptake in SDH-deficient GIST primary cells and downregulated CD36 in primary SDH-deficient GIST cells.

    Insulin (human) purchased from MedChemExpress. Usage Cited in: Theranostics. 2022 Nov 7;12(18):7699-7716.  [Abstract]

    For insulin tolerance tests, mice on HFD for 15 weeks received an intraperitoneal injection of Insulin (1.0 U/kg body weight) after 6 hours of fasting. Glucose level was measured in tail blood at 0, 15, 30, 60, 90, and 120 mins after glucose or insulin injection using a glucometer.

    Insulin (human) purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Mar 26;10(10):4705-4719.   [Abstract]

    Insulin tolerance tests (ITT) were performed by intraperitoneally injecting Insulin (0.75 unit/kg in 0.9% wt/vol saline) to mice that had been fasted for 6 h. Blood glucose levels were measured at 0, 15, 30, 60, and 120 minutes using an Infinity glucose meter.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Insulin (human) is a polypeptide hormone that regulates the level of glucose. Insulin (human) can be used for the diabetes mellitus[1][2].

    In Vitro

    The human insulin gene contains two intervening sequences, one is within the region transcribed into the 5'-untranslated segment of the mRNA and the other interrupts the C-peptide encoding region[1]. Human insulin is commonly used to treat type 2 diabetes[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Insulin (human) Related Antibodies
    In Vivo

    Insulin (human) (0.75 U/kg; ip; once) can significantly reduce blood glucose levels in 15 minutes[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Slc35d3-Flox mice and Slc35d3-wild type mice injected with 100 mg/mLl D-Glucose (HY-B0389)[1]
    Dosage: 0.75 U/kg
    Administration: ip; once
    Result: Significantly lowers blood glucose levels.
    Molecular Weight

    5807.57

    Formula

    C257H383N65O77S6
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture and light

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    H2O : 10 mg/mL (1.72 mM; ultrasonic and adjust pH to 2 with HCl)

    1 M Acetic acid : ≥ 10 mg/mL (1.72 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.1722 mL 0.8609 mL 1.7219 mL
    5 mM --- --- ---
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

    • Protocol 1

      Insulin(human)solution in dilute hydrochloric acid(pH:2~3)is diluted with PBS.(clear)

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 100.6%%

    SDS (397 KB)

    COA (241 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / 1 M Acetic acid 1 mM 0.1722 mL 0.8609 mL 1.7219 mL 4.3047 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Insulin (human) Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Insulin (human)11061-68-0Insulin ReceptorInhibitorinhibitorinhibit

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    Cat. No.:
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