Cysteinylglycine
Based on 1 Customer Validation
Cysteinylglycine (L-Cysteinylglycine; Cys-Gly) is a dipeptide formed by the peptide bond linkage between cysteine (Cysteine) and glycine (Glycine). Cysteinylglycine is an important metabolic intermediate in the human body, mainly derived from the degradation of glutathione (GSH). Cysteinylglycine reduces ferric iron to ferrous iron, drives the redox cycle of iron, generates reactive oxygen species (ROS), stimulates oxidative reactions, induces lipid peroxidation of human plasma LDL lipoproteins, and causes oxidative damage to DNA bases. Cysteinylglycine can be used as a biomarker to evaluate ischemic heart disease, breast cancer and other conditions.
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 19246-18-5
- Formula: C5H10N2O3S
- Molecular Weight:178.21
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Storage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KB 3-1 | IC50 |
9.42 mM
Compound: Cys-Gly
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Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay
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[PMID: 21657271] |
| KB-V1 | IC50 |
4.23 mM
Compound: Cys-Gly
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Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay
Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay
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[PMID: 21657271] |
Cysteinylglycine (48 h; 10 μM-50 μM) shows a significant 1.2- to 1.7-fold increase in human astrocytoma U373-MG cells after 48 h of treatment with various Nrf2 activators, compared with control cells[1].
Cysteinylglycine (0.78-25 μM; incubated at 20℃ in the dark for 10 min) can be accurately quantified by this reversed-phase ion-pair liquid chromatography method, with a linear response range of 0.78 to 25 μM, a limit of detection < 2 pmol, and the adduct can be stably stored at -80℃ for 14 days[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 19246-18-5
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Appearance Solid
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Molecular Weight 178.21
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Formula C5H10N2O3S
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Color White to off-white
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Synonyms
L-Cysteinylglycine; Cys-Gly; H-Cys-Gly-OH
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvent & Solubility
H2O : 175 mg/mL (981.99 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (701 KB)
- English - EN (701 KB)
- Français - FR (701 KB)
- Deutsch - DE (701 KB)
- Norwegian - NO (701 KB)
- Español - ES (701 KB)
- Swedish - SV (701 KB)
- Italian - IT (701 KB)
- Korean - KR (701 KB)
- Portuguese - PT (701 KB)
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Handling Instructions (2659 KB)
References
[1]. Steele ML, et al. Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells. Redox Biol. 2013;1(1):441-445. Published 2013 Sep 12. [Content Brief]
[2]. Mansoor MA, et al. Determination of the in vivo redox status of cysteine, cysteinylglycine, homocysteine, and glutathione in human plasma. Anal Biochem. 1992;200(2):218-229. [Content Brief]
[3]. Lin J, et al. Plasma cysteinylglycine levels and breast cancer risk in women. Cancer Res. 2007;67(23):11123-11127. [Content Brief]
[4]. Houghton SC, et al. Plasma B-vitamin and one-carbon metabolites and risk of breast cancer before and after folic acid fortification in the United States. Int J Cancer. 2019;144(8):1929-1940. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.6114 mL | 28.0568 mL | 56.1136 mL | 140.2839 mL |
| 5 mM | 1.1223 mL | 5.6114 mL | 11.2227 mL | 28.0568 mL | |
| 10 mM | 0.5611 mL | 2.8057 mL | 5.6114 mL | 14.0284 mL | |
| 15 mM | 0.3741 mL | 1.8705 mL | 3.7409 mL | 9.3523 mL | |
| 20 mM | 0.2806 mL | 1.4028 mL | 2.8057 mL | 7.0142 mL | |
| 25 mM | 0.2245 mL | 1.1223 mL | 2.2445 mL | 5.6114 mL | |
| 30 mM | 0.1870 mL | 0.9352 mL | 1.8705 mL | 4.6761 mL | |
| 40 mM | 0.1403 mL | 0.7014 mL | 1.4028 mL | 3.5071 mL | |
| 50 mM | 0.1122 mL | 0.5611 mL | 1.1223 mL | 2.8057 mL | |
| 60 mM | 0.0935 mL | 0.4676 mL | 0.9352 mL | 2.3381 mL | |
| 80 mM | 0.0701 mL | 0.3507 mL | 0.7014 mL | 1.7535 mL | |
| 100 mM | 0.0561 mL | 0.2806 mL | 0.5611 mL | 1.4028 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Cysteinylglycine Related Classifications
HY-113110 Related Classifications
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- Cysteinylglycine
- 19246-18-5
- L-Cysteinylglycine
- Cys-Gly
- H-Cys-Gly-OH
- Endogenous Metabolite
- Reactive Oxygen Species (ROS)
- DNA/RNA Synthesis
- cysteine
- glycine
- human plasma LDL lipoproteins
- one-carbon metabolism
- U373-MG human astrocytoma cells
- Alzheimer’s disease
- neuronal ectopeptidase
- glutathione (GSH)
- astrocyte-derived γ-glutamyl transpeptidase
- Nrf2 activator
- Inhibitor
- inhibitor
- inhibit